Conformance of the diagnostic criteria for diabetes mellitus estimated from the results of the oral glucose tolerance testsand glycated hemoglobin (HbA1c) level

2014 ◽  
Vol 60 (1) ◽  
pp. 36-38
Author(s):  
E A Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Diabetic Patients ◽  
Oral Glucose Tolerance ◽  
Study Population ◽  
Hba1c Measurement

The study population of 127 patients with type 2 diabetes mellitus (T2DM) risk factors underwent oral glucose tolerance test (OGTT) and HbA1c measurement for diagnostic reasons. HbA1c revealed less diabetic patients than OGTT (31% vs 43%). HbA1c >7% and OGTT were similar in confirming diabetes, but HbA1c <7% suggests the need for OGTT performance to validate the diagnosis.

scholarly journals The Effect of Prior Gestational Diabetes on the Shape of the Glucose Response Curve during an Oral Glucose Tolerance Test 3 Years after Delivery

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Timea Tänczer ◽  
Márk M. Svébis ◽  
Beatrix Domján ◽  
Viktor J. Horváth ◽  
Adam G. Tabák
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Glucose Response

Objective. Monophasic glucose response (MGR) during an oral glucose tolerance test (OGTT) and gestational diabetes mellitus (GDM) are predictors of type 2 diabetes mellitus (T2DM). We investigated the association between current MGR and (1) glucose tolerance during a pregnancy 3 years before and (2) current glucose tolerance status. We also sought (3) other determinants of MGR. Research Design and Methods. We conducted a nested case-control study of GDM (n=47 early GDM, diagnosed between 16 and 20 weeks of gestation; n=40 late GDM, diagnosed between 24 and 28 weeks of gestation) and matched healthy controls (n=37, normal glucose tolerance during pregnancy) all free from diabetes at follow-up 3.4±0.6 years after delivery. Glucose tolerance was determined by 2-hour 75 g OGTT. Monophasic and biphasic groups were defined based on serum glucose measurements during OGTT. Results. The biphasic group was younger, had lower triglyceride levels and area under the OGTT glucose curve, and was less frequently diagnosed with early GDM (25 vs. 45%, all p<0.05). Women with a biphasic response also tended to have lower systolic blood pressure (p<0.1). No differences were found in fasting and 2-hour glucose and insulin levels, or BMI. According to multiple logistic regression, MGR was associated with prior early GDM (OR 2.14, 95% CI 0.92-4.99) and elevated triglyceride levels (OR 2.28, 95% CI 1.03-5.03/log (mmol/l)). Conclusions. We found that more severe, early-onset GDM was an independent predictor of monophasic glucose response suggesting that monophasic response may represent an intermediate state between GDM and manifest type 2 diabetes.

scholarly journals Alarin Level Response to an Oral Glucose Tolerance Test in Subjects with Gestational Diabetes Mellitus

2020 ◽  
Vol 4 (2) ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Oral Glucose Tolerance Test ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance

Alarin has been reported to ameliorate insulin resistance in type 2 diabetis mellitus. However, until now, there is no report examined the relationship between alarin and gestational diabetes mellitus (GDM). Therefore, the purpose of this study is to examine the level of alarin in subjects with and without gestational diabetes mellitus. 30 healthy and 30 gestational diabetes mellitus subjects were recruited for this study. A 2-hour 75 g oral glucose tolerance test (OGTT) was performed at 24–28 weeks of pregnancy. GDM were diagnosed using nationally endorsed criteria (fasting [FPG], 1- or 2-hour blood glucose [at least one abnormal value]. Plasma alarin level was measured by ELISA. Plasma alarin levels were significantly higher GDM subjects than in healthy individuals (12. 3±1.4 ng/mL vs 7.8±0.8 ng/mL; p < .05).1- (18. 8±1.9 ng/mL) and 2-hour (24. 2±3.1 ng/mL) alarin levels in women with GDM were significantly increased at OGTT compared with women without GDM [1- (9.4±0.9 ng/mL); 2- (9.7±0.6 ng/mL)]. Plasma alarin positively correlated with FBG, HbA1c, HOMA-IR and insulin). The above results suggest that alarin might be associated in the pathogenesis of gestational diabetes mellitus.

Sign in / Sign up

Export Citation Format

Share Document