scholarly journals Numerical Investigation into Particle Separation Methods Using Inertial Focusing Behavior

2018 ◽  
Vol 26 (0) ◽  
pp. 157-160 ◽  
Author(s):  
Hirotake UDONO ◽  
Mikio SAKAI
Keyword(s):  
Numerical Investigation ◽  
Particle Separation ◽  
Inertial Focusing

scholarly journals High-resolution particle separation by inertial focusing in high aspect ratio curved microfluidics

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Javier Cruz ◽  
Klas Hjort
Keyword(s):  
High Resolution ◽  
Aspect Ratio ◽  
High Aspect Ratio ◽  
Biological Fluids ◽  
Essential Feature ◽  
Particle Separation ◽  
Size Difference ◽  
Inertial Focusing ◽  
Complex Samples ◽  
Wide Range

AbstractThe ability to focus, separate and concentrate specific targets in a fluid is essential for the analysis of complex samples such as biological fluids, where a myriad of different particles may be present. Inertial focusing is a very promising technology for such tasks, and specially a recently presented variant, inertial focusing in High Aspect Ratio Curved systems (HARC systems), where the systems are easily engineered and focus the targets together in a stable position over a wide range of particle sizes and flow rates. However, although convenient for laser interrogation and concentration, by focusing all particles together, HARC systems lose an essential feature of inertial focusing: the possibility of particle separation by size. Within this work, we report that HARC systems not only do have the capacity to separate particles but can do so with extremely high resolution, which we demonstrate for particles with a size difference down to 80 nm. In addition to the concept for particle separation, a model considering the main flow, the secondary flow and a simplified expression for the lift force in HARC microchannels was developed and proven accurate for the prediction of the performance of the systems. The concept was also demonstrated experimentally with three different sub-micron particles (0.79, 0.92 and 1.0 µm in diameter) in silicon-glass microchannels, where the resolution in the separation could be modulated by the radius of the channel. With the capacity to focus sub-micron particles and to separate them with high resolution, we believe that inertial focusing in HARC systems is a technology with the potential to facilitate the analysis of complex fluid samples containing bioparticles like bacteria, viruses or eukaryotic organelles.

Investigation of the Inertial Focusing Behavior in Curved Microfluidic Channels for Different Aspect Ratio

2016 ◽  
Author(s):  
Alireza Setayesh Hagh ◽  
Ali Dinler
Keyword(s):  
Particle Separation ◽  
Microfluidic Channels ◽  
Flow Conditions ◽  
Specific Flow ◽  
Inertial Focusing ◽  
Particle Focusing ◽  
Curved Channels ◽  
Aspect Ratios ◽  
Specific Number ◽  
Significant Attention

Inertial focusing has attracted a significant attention in microfluidics applications in recent years. Inertial focusing occurs only under specific flow conditions at which particles migrate across streamlines to a specific number of equilibrium positions. This behavior is mostly not sensitive to the particle size in straight channels. However, curved channels can allow sized based particle separation. In this study, curved channels with various aspect ratios have been investigated by numerical simulations. Consideration of flow regimes reveals that some conditions establish a high-quality single-particle focusing situation which is characterized by the alignment of particles within a narrow band. The outcomes of our numerical model contribute to the understanding of limitation of particle focusing and particle separation in curved microchannels.

Two step label free particle separation in a microfluidic system using elasto-inertial focusing and magnetophoresis

RSC Advances ◽  
2016 ◽  
Vol 6 (38) ◽  
pp. 32090-32097 ◽  
Author(s):  
Min Jung Kim ◽  
Doo Jin Lee ◽  
Jae Ryoun Youn ◽  
Young Seok Song
Keyword(s):  
Separation Efficiency ◽  
Free Particle ◽  
Particle Separation ◽  
Microfluidic System ◽  
Label Free ◽  
Inertial Focusing ◽  
High Separation

The high separation efficiency of particles and cells can be realized by exploiting a facile two step label free technique that consists of elasto-inertial focusing and magnetophoresis.

scholarly journals Inertial Focusing and Separation of Particles in Similar Curved Channels

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yue Ying ◽  
Ying Lin
Keyword(s):  
Reynolds Number ◽  
High Reynolds Number ◽  
Particle Separation ◽  
Separation Potential ◽  
Inertial Focusing ◽  
Focusing Effect ◽  
Serpentine Channel ◽  
Curved Channels ◽  
Wave Channel ◽  
High Reynolds

Abstract Inertial particle focusing in curved channels has enormous potential for lab-on-a-chip applications. This paper compares a zigzag channel, which has not been used previously for inertial focusing studies, with a serpentine channel and a square wave channel to explore their differences in terms of focusing performance and separation possibilities. The particle trajectories and fluid fields in the curved channels are studied by a numerical simulation. The effects of different conditions (structure, Reynolds number, and particle size) on the competition between forces and the focusing performance are studied. The results indicate that the zigzag channel has the best focusing effect at a high Reynolds number and that the serpentine channel is second in terms of performance. Regarding the particle separation potential, the zigzag channel has a good performance in separating 5 μm and 10 μm particles at ReC = 62.5. In addition, the pressure drop of the channel is also considered to evaluate the channel performance, which has not been taken into account in the literature on inertial microfluidics. This result is expected to be instructive for the selection and optimization of inertial microchannel structures.

Numerical investigation of particle separation in Y-shaped bifurcating microchannels

Particuology ◽  
2020 ◽  
Author(s):  
Mahya Meyari ◽  
Zeinab Salehi ◽  
Reza Zarghami ◽  
Mahdi Saeedipour
Keyword(s):  
Numerical Investigation ◽  
Particle Separation

scholarly journals A density-based threshold model for evaluating the separation of particles in heterogeneous mixtures with curvilinear microfluidic channels

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Chun Kwan Chen ◽  
Bee Luan Khoo
Keyword(s):  
Particle Density ◽  
Threshold Model ◽  
Particle Separation ◽  
Microfluidic Channels ◽  
Label Free ◽  
Inertial Focusing ◽  
Irregular Shapes ◽  
Mathematical Expressions ◽  
Nonlinear Channels ◽  
Sorting Efficiency

Abstract Particle separation techniques play an important role in biomedical research. Inertial focusing based microfluidics using nonlinear channels is one of the promising label-free technologies for biological applications. The particle separation is achieved as a result of the combination of inertial lift force (FL) and Dean drag force (FD). Although the mathematical expressions of FL and FD have been well derived in prior studies, they are still complicated, which limits their popularity in practice. Recent studies modified these expressions through experiments and proposed a threshold model, which assumes that only particles larger than the threshold will be well focused. Although this threshold model has been used in recent studies, two varying versions of the threshold model (TM1 and TM2) prevents standardisation in practice. In addition, both models were developed with regular low-density particles and may not be applicable to samples with higher density or samples with irregular shapes. Here, we evaluated the threshold models with samples of different densities. Based on these evaluations, we derived a modified model (TM4), which additionally considers the factor of particle density to improve the accuracy of existing models. Our results demonstrated that TM4 could more reliably predict the sorting efficiency of samples within a wider density range.

scholarly journals High-Resolution Particle Separation by Inertial Focusing in High Aspect Ratio Curved Microfluidics

2021 ◽  
Author(s):  
Javier Cruz ◽  
Klas Hjort
Keyword(s):  
High Resolution ◽  
Aspect Ratio ◽  
High Aspect Ratio ◽  
Biological Fluids ◽  
Essential Feature ◽  
Particle Separation ◽  
Size Difference ◽  
Inertial Focusing ◽  
Complex Samples ◽  
Wide Range

Abstract The ability to focus, separate and concentrate specific targets in a fluid is essential for the analysis of complex samples such as biological fluids, where a myriad of different particles may be present. Inertial focusing is a very promising technology for such tasks, and specially a recently presented variant, inertial focusing in High Aspect Ratio Curved systems (HARC sytsems), where the systems are easily engineered and focus the targets together in a stable position over a wide range of particle sizes and flow rates. However, although convenient for laser interrogation and concentration, by focusing all particles together, HARC systems lose an essential feature of inertial focusing: the possibility of particle separation by size. Within this work, we report that HARC systems not only do have the capacity to separate particles but can do so with extremely high resolution, which we demonstrate for particles with a size difference down to 80 nm. In addition to the concept for particle separation, a model considering the main flow, the secondary flow and a simplified expression for the lift force in HARC microchannels was developed and proven accurate for the prediction of the performance of the systems. The concept was also demonstrated experimentally with three different sub-micron particles (0.79, 0.92 and 1.0 µm in diameter) in silicon-glass microchannels, where the resolution in the separation could be modulated by the radius of the channel. With the capacity to focus sub-micron particles and to separate them with high resolution, we believe that inertial focusing in HARC systems is a technology with the potential to facilitate the analysis of complex fluid samples containing bioparticles like bacteria, viruses or eukaryotic organelles.

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