Background and Objectives. Response-focused emotion regulation (RF-ER) strategies may alter people’s evoked emotions, influencing psychophysiology, memory accuracy, and affect. Researchers have found that participants engaging in expressive suppression (ES; a RF-ER strategy) experience increased sympathetic nervous system arousal, affect (i.e., higher subjective anxiety and negative emotion), and lowered memory accuracy. It is unclear, however, whether all RF-ER strategies exert maladaptive effects. Expressive dissonance (ED; displaying an expression opposite from how one feels) is a RF-ER strategy, and thus likely considered “maladaptive”. As outlined by the facial feedback hypothesis, however, smiling may increase positive emotion, suggesting it may be an adaptive strategy. We compared the effects of ED and ES to a control condition on psychophysiology, memory accuracy, and affect, to assess whether ED is an adaptive RF-ER strategy, relative to ES. Methods. We randomly assigned 144 female participants to engage in ED, ES, or to naturally observe, while viewing negative and arousing images. We recorded electrodermal activity and self-reported affect throughout the experiment and participants completed memory tasks. Results. There were no differences between groups across outcomes. Conclusion. Engaging in ES or ED may not lead to negative or positive impacts, shedding doubt on the common conclusion that specific strategies are categorically adaptive or maladaptive.