scholarly journals Comparative effectiveness of intra-articular administration of different drugs of hyaluronic acid with various physico-chemical properties in knee osteoarthritis

2021 ◽  
Vol 15 (6) ◽  
pp. 48-54
Author(s):  
E. A. Belyaeva ◽  
A. S. Fatenko ◽  
O. S. Avdeeva ◽  
S. V. Belyaeva
Keyword(s):  
Hyaluronic Acid ◽  
Knee Osteoarthritis ◽  
Randomized Study ◽  
Chemical Properties ◽  
Subjective Assessment ◽  
Serious Adverse Events ◽  
Significant Deterioration ◽  
Important Place ◽  
Womac Index ◽  
Physico Chemical

Knee osteoarthritis (KOA) is a chronic disease that leads to a significant deterioration in the quality of life and disability. In the treatment of OA, hyaluronic acid (HA) drugs have an important place.Objective: to compare the effectiveness of ROA treatment with different HA drugs with different physicochemical properties and molecular weight.Patients and methods. A 12-week prospective randomized study of the comparative efficacy of a single intra-articular injection of three HA drugs – Armaviscon Forte (AF), Flexotron Cross (FCr) and Flexotron Ultra (FUL) was carried out. The study group consisted of 90 patients with knee osteoarthritis, aged from 43 to 50 years (the majority were women – 63.3%) with an initial severity of pain >40 mm according to the visual analogue scale (VAS). The result of therapy was assessed by the dynamics of pain (VAS), WOMAC index, and subjective assessment of the effect 3 months after intra-articular administration of HA.Results and discussion. Eight patients dropped out of the study: in the AF group – 3, FCr – 4, FUL – 1. After 90 days, the decrease in pain compared to baseline values in the AF group was 30%, in FCr – 46% and in FUL – 57% (p ≤0,05), and the dynamics of the WOMAC index – 27, 36, and 42%, respectively. After 90 days, 85.0, 93.4 and 96.5% of patients noted improvement and significant improvement in the AF, FCr and FUL groups, respectively. No serious adverse events were recorded.Conclusion. All investigated drugs demonstrated high analgesic potential, but the best clinical effect was observed with FUL.

scholarly journals US-Approved Intra-Articular Hyaluronic Acid Injections are Safe and Effective in Patients with Knee Osteoarthritis: Systematic Review and Meta-Analysis of Randomized, Saline-Controlled Trials

2013 ◽  
Vol 6 ◽  
pp. CMAMD.S12743 ◽  
Author(s):  
Larry E. Miller ◽  
Jon E. Block
Keyword(s):  
Systematic Review ◽  
Hyaluronic Acid ◽  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Serious Adverse Events ◽  
Safety Outcome ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

We conducted a systematic review and meta-analysis of randomized saline-controlled trials to determine the safety and efficacy of US-approved intra-articular hyaluronic acid (IAHA) injections for symptomatic knee osteoarthritis. A total of 29 studies representing 4,866 unique subjects (IAHA: 2,673, saline: 2,193) were included. IAHA injection resulted in very large treatment effects between 4 and 26 weeks for knee pain and function compared to pre-injection values, with standardized mean difference (SMD) values ranging from 1.07–1.37 (all P < 0.001). Compared to saline controls, SMDs with IAHA ranged from 0.38–0.43 for knee pain and 0.32–0.34 for knee function (all P < 0.001). There were no statistically significant differences between IAHA and saline controls for any safety outcome, including serious adverse events (SAEs) ( P = 0.12), treatment-related SAEs ( P = 1.0), study withdrawal ( P = 1.0), and AE-related study withdrawal ( P = 0.46). We conclude that intra-articular injection of US-approved HA products is safe and efficacious in patients with symptomatic knee osteoarthritis.

scholarly journals STUDY OF THE PLATELET-RICH PLASMA CLINICAL EFFICACY IN THE TREATMENT OF KNEE OSTEOARTHRITIS

2016 ◽  
Vol 7 (3) ◽  
pp. 54-60
Author(s):  
G D Lazishvili ◽  
К A Egiazaryan ◽  
A A Akhpashev ◽  
M A Danilov ◽  
M A Strakhov ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Knee Osteoarthritis ◽  
Clinical Efficacy ◽  
Detection Rate ◽  
Platelet Rich Plasma ◽  
Analog Scale ◽  
Womac Index ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The study of platelet-rich plasma efficacy in the treatment of patients with knee osteoarthritis (OA) was performed. 188 patients were included and divided into three groups. Group 1 - 82 patients with OA, where hyaluronic acid was used for treatment, Group 2 - 36 patients, and Platelet Rich Plasma (PRP) and hyaluronic acid were used, Group 3 - 70 patients, only PRP was used. It`s been found that the use of PRP for treatment is characterized by a pronounced clinical efficacy compared with use of hyaluronic acid, which manifests in reduced detection rate of edema, hyperthermia and hyperemia. The use of PRP leads to pain reduction in the knee joint and increase the functionality of patients, that confirmed by more pronounced declining of visual analog scale indicators, Leken index and the WOMAC index values increase. The presented results of study are consistent with authors who believe that the lack of side effects and complications when using PRP indicates the safety of its use in clinical practice.

Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine

2017 ◽  
Vol 68 (2) ◽  
pp. 384-386 ◽  
Author(s):  
Danut Vasile ◽  
Raluca Iancu ◽  
Camelia Bogdanici ◽  
Emil Ungureanu ◽  
Dana Ciobotea ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Physical Properties ◽  
Biomedical Applications ◽  
Chemical Properties ◽  
Elastic Behavior ◽  
Current Evidence ◽  
Hydroxyl Groups ◽  
Carboxylate Group ◽  
Medical Problems ◽  
Physico Chemical

Hyaluronic acid is a mucopolysaccharide encountered in most body fluids and extracellular matrix. The aim of our review is to summarize current evidence about chemico-physical properties of hyaluronic acid, highlighting biomedical applications of hyaluronan derivatives. It is a glycosaminoglycan made of repeating disaccharide units containing a carboxylate group, four hydroxyl groups and one carboxylate group, with hydrophilic properties. Its particular structure with multiple coils forming an entangled network results in unique pseudoplastic and viscoelastic characteristics. Its viscous and elastic behavior, depending on the applied strain, makes hyaluronan widely applicable in biomedical field. The large amount of functions and applications is determined by the physico-chemical properties, which allows a polymorphism of the hyaluronic acid structures depending on the molecular weight variations, concentration and ionic status. It is currently used in ophthalmology, orthopedics and rheumatology, in plastic surgery, surgery and otolaryngology as well. Already widely used in clinical practice, hyaluronic acid proves to be often the best solution for difficult medical problems. Future developments in nanomedicine and drug delivery linked to hyaluronic acid are emerging.

scholarly journals Structure and physico-chemical properties of fibrillary collagen fabric modified by silicon dioxide and hyaluronic acid

2020 ◽  
Vol 64 (2) ◽  
pp. 173-185
Author(s):  
A. A. Gaidash ◽  
V. K. Krut’ko ◽  
A. I. Kulak ◽  
O. N. Musskaya ◽  
K. V. Skrotskaya ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Silicon Dioxide ◽  
Calcium Phosphates ◽  
Chemical Properties ◽  
Collagen Fibrils ◽  
Oh Groups ◽  
Laboratory Rats ◽  
Physico Chemical ◽  
Stretching Vibration ◽  
Natural Composites

The connective tissue sheaths of paravertebral tendons (peritenons) of white laboratory rats treated with silicon dioxide and hyaluronic acid were studied. It was found that peritenones are natural composites with orthogonal anisotropy with a developed system of interstitial porous membranes that regulate tissue hydrodynamic flows. The extracellular matrix of peritenons contains carbonate-hydroxyapatite and calcium hydroxide in the amorphized state. Silicon dioxide and hyaluronate form hydrophobic silicate and hyaluronate coatings of collagen fibrils (encapsulation), strengthen bonds in Amides I, II, III, reduce the intensity of the bands of bound hydroxyl and stretching vibration bands of phosphate groups, which indicates the replacement of OH groups with carbonate ions and the suppression synthesis of hydroxyapatite. A key mechanism for reducing the intensity of apatitogenesis is the encapsulation of collagen fibrils, accompanied by screening the centers of epitaxial interactions that are structured during heterogeneous nucleation of calcium phosphates. In SBF biomimetic fluid, the deforming effect of modifying agents is leveled, but hydration and decomposition of fibrillar collagen increase. Moreover, against the background of excess supply of exogenous phosphates and carbonates from SBF, apatitogenesis in peritenons is carried out mainly by the mechanism of homogeneous nucleation.

Formulation and Standardization of Dill Based Gherkin Pickles: A Study on Physico-Chemical and Sensory Attributes

2017 ◽  
Vol 54 (4) ◽  
pp. 387
Author(s):  
Madhusmita Sahoo ◽  
Jamuna Prakash
Keyword(s):  
Chemical Properties ◽  
Sensory Attributes ◽  
Anethum Graveolens ◽  
Traditional Foods ◽  
Important Place ◽  
Vegetable Products ◽  
Physico Chemical ◽  
The World ◽  
Sensory Parameters ◽  
Stabilization Period

Pickles occupy an important place among the processed traditional foods in India. Pickling of vegetables with traditional herbs and spices has good scope for the trade development overseas as India is the second largest vegetable producer in the world. Different variants of gherkin (Curcumis anguria) pickles were developed using the traditional herb dill leaves (Anethum graveolens), dill flavour and spices available locally. The pickles were freshly packed in glass jars through aseptic packing technology by the use of vacuum sealing and pasteurization. The physico-chemical properties and sensory attributes of the freshly packed pickles (soon after pasteurization) in comparison with the pickles post completion of the osmosis process i.e. after 15 days of stabilization period were studied. The study showed that use of Dill alone or along with other spices in either fresh or dehydrated form, enhanced the flavour profile of gherkin pickles. All the variants were very well accepted among the panel in pre- and post-stabilization. Pickles were stabilized well after 15 days of storage. Sodium benzoate used as preservative in two pickle variants enhanced the shelf life without affecting the acceptance criteria/sensory parameters of the vacuum sealed pickles. Though this study focused only on gherkin pickles, dill leaves can be very well explored in other vegetable products that can be processed and stored for longer time.

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