scholarly journals Systematic analysis of the molecular pathophysiology of tenosynovitis: promise for using chondroitin sulfate and glucosamine sulfate

2020 ◽  
Vol 12 (2) ◽  
pp. 64-71 ◽  
Author(s):  
I. Yu. Torshin ◽  
O. A. Gromova ◽  
A. M. Lila ◽  
O. A. Limanova
Keyword(s):  
Chondroitin Sulfate ◽  
Glucosamine Sulfate ◽  
Systematic Analysis ◽  
Molecular Pathophysiology

scholarly journals On the neurological roles of chondroitin sulfate and glucosamine sulfate: a systematic analysis

2019 ◽  
Vol 11 (3) ◽  
pp. 137-143 ◽  
Author(s):  
O. A. Gromova ◽  
I. Yu. Torshin ◽  
V. A. Semenov ◽  
L. I. Stakhovskaya ◽  
K. V. Rudakov
Keyword(s):  
Data Mining ◽  
Neurodegenerative Diseases ◽  
Chondroitin Sulfate ◽  
Affective Disorders ◽  
Experimental Studies ◽  
Glucosamine Sulfate ◽  
Systematic Analysis ◽  
Convulsive Disorders ◽  
Neuropsychological Diseases

Chondroitin sulfate (CS) and glucosamine sulfate (GS) are widely used as chondroprotectors. Data mining of 42,051 publications on the effects of CS/GS showed that impairments in the their metabolism were characteristic of ischemic, neurodegenerative diseases, convulsive disorders or conditions, and neuropsychological diseases (schizophrenia, affective disorders). The results of experimental studies indicate that it is expedient to use CS and GS in the therapy of ischemic and neurodegenerative diseases.

scholarly journals Prospects for the use of chondroitin sulfate and glucosamine sulfate with osteoarthritis associated with pathology of the kidneys and urinary system

2020 ◽  
Vol 13 (1) ◽  
pp. 23-34 ◽  
Author(s):  
I. Yu. Torshin ◽  
A. М. Lila ◽  
O. A. Limanova ◽  
O. A. Gromova
Keyword(s):  
Chondroitin Sulfate ◽  
Glucosamine Sulfate ◽  
Topological Data Analysis ◽  
Predictive Analysis ◽  
Urinary System ◽  
Normal Functioning ◽  
Systematic Analysis ◽  
Inflammatory Cascade ◽  
Glomerular Nephritis ◽  
Tract Infections

Introduction. Chondroitin sulfate (CS) and glucosamine sulfate (GS), widely used as chondroprotectors, can maintain the normal functioning of the urinary system but their effect has not been analyzed systematically.Aim: to perform a systematic analysis of the possibilities of using CS and GS in patients with pathology of the kidneys and urinary system.Materials and methods. Predictive analysis of 2,093 publications on the interactions of CS/GS with the functioning of the kidneys and other organs of the urinary system found at the request “(urinary OR bladder OR kidney) AND (glucosamine OR chondroitin)” by methods of the theory of topological data analysis.Results. Disorders of cholesterol and glucosamine metabolism are characteristic of cystitis, glomerular nephritis, urinary tract infections (UTIs), urolithiasis, proteinuria, and formation of diabetic nephropathy. In addition to inhibiting the pro-inflammatory cascade NF-kB, CS/GS contribute to eliminating the deficiency of glycosaminoglycans in the pathology of urothelium, inhibit urolithiasis, inhibit the synthesis of pro-inflammatory nitric oxide NO in macrophages, and modulate O-glycosylation processes.Conclusion. The results of fundamental and clinical studies show that subsidies of CS/GS substances of pharmacological quality per os and CS instillation in the bladder (in particular, in combination with hyaluronic acid) are the means of choice for patients suffering from osteoarthritis and diseases of the urinary system. Highly purified pharmacological CS substances are part of the preparation Chondroguard.

Evaluation of the efficacy and safety of a combination of chondroitin sulfate and glucosamine sulfate for knee and hip osteoarthritis in real clinical practice

2020 ◽  
Vol 14 (4) ◽  
pp. 82-90
Author(s):  
A. E. Karateev ◽  
Yu. V. Barysheva ◽  
Ya. V. Belokon ◽  
T. Yu. Bolshakova ◽  
Yu. Yu. Grabovetskaya ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Chondroitin Sulfate ◽  
Hip Osteoarthritis ◽  
Glucosamine Sulfate ◽  
New Drugs ◽  
Observational Research ◽  
Efficacy And Safety ◽  
Safety Level ◽  
Lequesne Index ◽  
Joint Health

A combination of chondroitin and glucosamine is widely used in clinical practice as both a symptomatic and structure-modifying agent for the treatment of osteoarthritis (OA). The emergence of new drugs based on this combination substantially expands treatment options for OA therapy.Objective: to evaluate the efficacy and safety of Artroflex® that is a combination of chondroitin sulfate 400 mg and glucosamine sulfate 500 mg (CS + GS) to support joint health in patients with knee and/or hip OA.Patients and methods. When implementing an open observational research program, the results of using the CS + GS complex were assessed in 644 OA patients (74.7% women) (mean age, 58.0±14.6 years) who experienced moderate/severe pain and required to continuously take non-steroidal anti-inflammatory drugs (NSAIDs). The CS + GS complex was prescribed in a dose of 2 capsules per day for 3 months. The investigators estimated changes in pain on movement by a 0 to 10 verbal pain scale, general health (GH) by a 0–10 visual analogue scale), the Lequesne index, the need for NSAIDs, and patient satisfaction with treatment and its tolerance.Results and discussion. After 3-month therapy, there were decreases in pain intensity by 49.2±16.8%, GH scores by 45.6±18.1%, the Lequesne index from 9.0 [6.0; 13.0] to 5.0 [3.0; 9.0]; less than half (45.2%) of the patients still needed for NSAIDs. 82.2% of patients were satisfied or completely satisfied with treatment results; 89.6% reported good treatment tolerance.Adverse events (apparently associated with NSAID use) were recorded in 2.2% of cases. There were no serious complications that required CS + GS treatment discontinuation or hospitalization.Conclusion. The findings have indicated that Artroflex® used to support joint health is an effective agent that controls OA symptoms and has a good safety level.

Sign in / Sign up

Export Citation Format

Share Document