scholarly journals Central giant cell granuloma of the maxilla: a case re-port

2017 ◽  
Vol 5 (2) ◽  
pp. 145
Author(s):  
Najwa Alchalabi ◽  
Hayder Salih ◽  
Ahmed Merza
Keyword(s):  
Giant Cell ◽  
Unusual Case ◽  
Clinical Presentation ◽  
Benign Lesion ◽  
Giant Cell Granuloma ◽  
Case Presentation ◽  
Central Giant Cell Granuloma ◽  
First Choice ◽  
Bone Cortex

Introduction: Central giant-cell is a benign lesion that predominantly involves the bone of the mandible and maxilla with a wide variation of its behavior. Surgery usually is the first choice in treatment of central giant cell granuloma.Case Report: In this case report we present a 29 years-old female with well define swelling on left maxilla. Diagnosis through incisional biopsy showed a central giant cell granuloma. Surgery with curettage was our treatment option with a follow up( 2 years ), No recurrence was reported.Discussion: Information on the maxillary central giant cell granuloma in published studies is insufficient. So here we present our case as unusual case presentation. Differential diagnosis of this case included osteosarcoma (parosteal type) since the tumor clinical presentation in periosteous tissue adjacent to the bone cortex and showed rapid growth. We chose the conventional surgical treatment by simple surgical curettage by mid-face degloving approach to avoid any facial scaring.

scholarly journals Central giant-cell granuloma located in the mandibular symphyseal region of a child

2018 ◽  
Vol 24 (2) ◽  
pp. 53-56
Author(s):  
Aurélien Bonolis ◽  
Edouard Euvrard ◽  
Christophe Meyer ◽  
Aurélien Louvrier
Keyword(s):  
Giant Cell ◽  
Postoperative Period ◽  
Clinical Presentation ◽  
Osteolytic Lesion ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Mandibular Tumor ◽  
Dental Lesions ◽  
Delay In Treatment

Introduction: Central giant-cell granuloma (CGCG) is a rare mandibular tumor. The originality of this case lies in its clinical presentation, with a delay in treatment despite a significant aesthetic impact. Observation: An 8-year-old boy whose chin had been swelling for three (3) months was referred to have a consultation. The medical imaging examination revealed a well-defined osteolytic lesion of about 3 cm and round in shape. The lesion was surgically treated by enucleation. The anatomopathological examination provided evidence of a CGCG. Conclusion: Postoperative period was aesthetically acceptable, there were no nervous or dental lesions and no relapse at the 6-month follow-up.

An Unusual Case of Maxillary Central Giant Cell Granuloma

2016 ◽  
Vol 2 (1) ◽  
pp. 55
Author(s):  
Ruchika Kapoor ◽  
FrenyRashmiraj Karjodkar ◽  
Kaustubh Sansare ◽  
AmareshChandra Dora
Keyword(s):  
Giant Cell ◽  
Unusual Case ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma

scholarly journals Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

2022 ◽  
Author(s):  
Monir Moradzadeh Khiavi ◽  
Abbas Karimi ◽  
Hassan Mirmohammad Sadeghi ◽  
Samira Derakhshan ◽  
Seyed Mobin Tafreshi ◽  
...  
Keyword(s):  
Giant Cell ◽  
Benign Lesion ◽  
Excisional Biopsy ◽  
Giant Cells ◽  
Histopathological Analysis ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Odontogenic Fibroma ◽  
Central Odontogenic Fibroma

Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.  

scholarly journals A Conservative Surgical Approach Towards Central Giant Cell Granuloma: A Case Report

2018 ◽  
Vol 30 (3) ◽  
pp. 1-4
Author(s):  
Ahmed Al-Qattan
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Surgical Approach ◽  
Pyogenic Granuloma ◽  
Histopathological Analysis ◽  
Giant Cell Granuloma ◽  
Case Presentation ◽  
Central Giant Cell Granuloma ◽  
History Of ◽  
Bony Lesion

Central giant cell granuloma (CGCG) is an infrequent benign bony lesion of unpredictably aggressive behavior. The precise lesion character is debatable and remains inconclusive. However, three main theories were proposed: a sensitive lesion, a kind of neoplasm, or a developmental anomaly. This is a case presentation of a 16-year-old boy with a dental history of extraction of the lower right first molar, presented to hospital with two months history of swelling in the aforementioned area after the procedure. First biopsy of the swelling was performed outside the Kingdom of Bahrain. As per histopathological findings, the swelling was described as pyogenic granuloma. Second biopsy with necessary workup was conducted in the Kingdom of Bahrain and was confirmed as central giant cell granuloma through histopathological analysis; it was removed surgically.

Surgical treatment and reconstruction of central giant cell granuloma (CGCG) of mandible of aggressive behaviour – case report and literature review

2019 ◽  
Vol 8 (3) ◽  
pp. 1-5
Author(s):  
Agnieszka Piotrowska-Seweryn ◽  
Krzysztof Oleś ◽  
Maciej Grajek ◽  
Mykola Chekan ◽  
Adam Maciejewski ◽  
...  
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Free Flap ◽  
Aggressive Behaviour ◽  
Positive Staining ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Dental Implantation ◽  
Fibular Free Flap

Introduction Central giant cell granuloma (CGCG) is a benign tumor-like lesion of a bone, mainly localized in mandible. It usually occurs in children and young adults under 30 y.o., predominantly in females. The etiology of the disease remains unknown. Clinically, two different types of CGCG have been distinguished – an unaggressive one, in which the granuloma grows slowly, often asymptomatically, and aggressive type which is characteristic for increased bone destruction, severe pain, large size, rapid growth, high recurrence rate and complications such as root resorption, tooth displacement or cortical bone perforation. The treatment of CGCG depends on its type. In cases of granulomas of aggressive behaviour the following therapeutic procedures have been proposed: intralesial corticosteroid injections, interferon and calcitonin therapy as well as immunotherapy with anti-bone resorptive human monoclonal antibody like denosumab. However, in most cases nonsurgical management remains insufficient. Also, local curettage of the lesion results in high risk of recurrence. Therefore, radical surgical resection, commonly combined with bone reconstruction, is the most recommended way of treatment for aggressive of CGCG. Case report The authors present a case of a 31-year-old female patient treated at the Department of Oncological and Reconstructive Surgery, Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology in Gliwice due to central giant cell granuloma of a mandible. The resection of CGCG localized in mandible on the right side together with fibular free flap reconstruction has been performed, with satisfactory aesthetic effect. Positive staining for CD68 and CD31 was found in immunohistochemic examination and expression of Ki67 marker was 13%. No complications were reported in the postoperative period. The six-month follow up revealed no recurrences. Conclusions The authors claim that radical surgical management should be performed in all patients with CGCG of aggressive behaviour. Fibular free flap is recommended for reconstruction in large bone defects. It results in tumor-free margins at the resection and satisfactory cosmetic outcome. Quality of life and facial appearance can be improved with dental implantation after certain disease-free period. A regular follow-up is essential as an element of holistic oncological process.

scholarly journals Central Giant Cell Granuloma Treated with Intralesional Corticosteroid Injections and Bisphosphonates: A Long-Term Follow-Up Case Study

2019 ◽  
Vol 14 (2) ◽  
pp. 497-502 ◽  
Author(s):  
Raíssa Pinheiro de Mendonça ◽  
Geovanni Pereira Mitre ◽  
Flavio Henrique Real ◽  
Maria Sueli da Silva Kataoka ◽  
Sérgio de Melo Alves Júnior ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid ◽  
Long Term Follow Up ◽  
Corticosteroid Injections

Management of recurrent central giant cell granuloma of mandible using intralesional corticosteroid with long-term follow-up

2020 ◽  
Vol 13 (9) ◽  
pp. e237200
Author(s):  
Kumar Nilesh ◽  
Anuj Dadhich ◽  
Rahul Patil
Keyword(s):  
Giant Cell ◽  
Osteolytic Lesion ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid ◽  
Ablative Surgery ◽  
Long Term Follow Up ◽  
Intralesional Injections

Central giant cell granuloma (CGCG) is an expansile osteolytic lesion of the jawbone. Conventional treatment of CGCG is surgical and vary from simple curettage to more aggressive resection of the jaw. However, surgical management is associated with drawbacks including requirement of hospitalisation and general anaesthesia, damage to vital anatomic structures and continuity defect of the mandible requiring reconstruction surgery. Use of intralesional injections of corticosteroid for the management of CGCG have been inconsistently used as an alternative non-surgical method of management of CGCG with varying success. While the use of such conservative modality over ablative surgery can significantly reduce postoperative morbidity, follow-up of such cases for a long period is important to study the possible recurrence. This paper reports successful treatment of a recurrent CGCG of posterior mandible by intralesional administration of triamcinolone acetonide in a 27-year old female patient, with long-term follow-up of 10 years.

scholarly journals Peripheral giant cell granuloma associated with a dental implant

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Rafaela Carriço Porto Baesso ◽  
Maria Carolina de Lima Jacy Monteiro Barki ◽  
Rebeca de Souza Azevedo ◽  
Karla Bianca Fernandes da Costa Fontes ◽  
Débora Lima Pereira ◽  
...  
Keyword(s):  
Giant Cell ◽  
Histological Examination ◽  
Dental Implant ◽  
Excisional Biopsy ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Case Presentation ◽  
Peripheral Giant Cell Granuloma ◽  
Left Mandible

Abstract Background Peripheral giant cell granuloma (PGCG) is an uncommon pathology that affects gingival or alveolar mucosa. Although PGCG can be associated with dental implants, little is known about this lesion and implant osseointegration as well as its etiopathogenesis and the treatments available. This study sought to report a rare case of PGCG associated with dental implant, emphasizing its clinical and histopathological aspects. Case presentation A 53-year-old man had an exophytic, reddish lesion, around a crown attached to a dental implant located in the left mandible. Radiographically, there was bone loss around the implant. After excisional biopsy, histological examination revealed a submucosal proliferation of multinucleated giant cells rendering the diagnosis of peripheral giant cell granuloma. Patient has been under follow-up for 6 months with no recurrence. Conclusions Peri-implant lesions must be completely removed to prevent recurrence of PGCG and implant failure, even in cases suspected to be reactive. Besides, histological examination must be performed on all peri-implant reactions to achieve the appropriate diagnosis and, consequently, the best treatment and follow up.

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