scholarly journals Electroanalysis of Diazepam on Nanosize Conducting Poly (3-Methylthiophene) Modified Glassy Carbon Electrode

2014 ◽  
Vol 17 (3) ◽  
pp. 185-190 ◽  
Author(s):  
A. Lakshmi ◽  
G. Gopu ◽  
S. Thanikaikarasan ◽  
T. Mahalingam ◽  
Peggy Alvarez ◽  
...  
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Impedance ◽  
Limit Of Detection ◽  
Detection Sensitivity ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Peak Current ◽  
Real Sample Analysis ◽  
Relative Standard

A glassy carbon electrode (GCE) was modified with nanosize poly (3-methylthiophene) (P3MT) and used for the sensitive voltammetric determination of diazepam. The cyclic voltammetric response of the bare GCE was compared with the P3MT modified electrode. Electrochemical impedance response of diazepam on modified GCE was studied by various concentrations of diazepam from 0.2 μM to 0.6 μM. The poly (3-methylthiophene) modified glassy carbon electrode (P3MT/GCE) can greatly enhance the peak currents and the detection sensitivity of diazepam under optimal conditions. The quantitative analysis of diazepam was made by the DPSV method. The experimental results showed that the peak current increased with the increase in concentration of diazepam. A calibration was made, which indicated the linear dependence of peak current with concentration (ip = 13.31Conc. + 0.4359R2 = 0.9948) in the range od determination and ot was found to be good between 0.2 and 1.07 μg/L. The limit of detection was 0.1μg/mL. The reproducibility of the stripping signal was realized in terms of relative standard deviation for 6 identical measurements and was found to be 2.6%. The effect of interference of different cations and anions on the oxidation of diazepam was studied. Real sample analysis of diazepam was also studied through DPSV.

Sensitive Detection of Levocetirizine as a new Generation Antihistamine by Stripping Square Wave Voltammetry

2020 ◽  
Vol 16 (4) ◽  
pp. 424-437
Author(s):  
Kubra Ozturk ◽  
Nurgul K. Bakirhan ◽  
Sibel A. Ozkan ◽  
Bengi Uslu
Keyword(s):  
Electrochemical Sensor ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Differential Pulse ◽  
Real Sample ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Square Wave ◽  
Real Sample Analysis ◽  
Tablet Dosage

Background:: new and selective electrochemical sensor was developed for the determination of levocetirizine dihydrochloride, which is an antihistaminic drug. Method:: The investigation was performed by using cyclic, differential pulse and square wave voltammetric methods on the β-cyclodextrin modified glassy carbon electrode. It is thereby planned to obtain information about levocetirizine determination and its mechanism. Result:: The efficiency of experimental parameters including pH, scan rate, and accumulation potential and time on the anodic response of levocetirizine dihydrochloride was studied. By employing the developed method and under optimized conditions, the current showed linear dependence with a concentration in the range between 2 × 10-8 M and 6 × 10-6 M in pH 2.0 Britton Robinson (BR) buffer. Conclusion:: The achieved limits of detection and quantification were found as 3.73 × 10-10 M and 1.24 × 10-9 M, respectively. In addition, the possibility of applying the developed sensor for real sample analysis was investigated, so β-cyclodextrin modified glassy carbon electrode was used to determine levocetirizine dihydrochloride in Xyzal® tablet dosage form. Finally, this sensor was successfully applied to the real sample as a selective, simple, reproducible, repeatable electrochemical sensor.

scholarly journals Electrochemical antioxidant screening and evaluation based on guanine and chitosan immobilized MoS2 nanosheet modified glassy carbon electrode (guanine/CS/MoS2/GCE)

2020 ◽  
Vol 18 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Ping Tang ◽  
Xiaosheng Tang ◽  
Shiyong Mei ◽  
Yixi Xie ◽  
Liangliang Liu ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Antioxidant Capacity ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Carbon Electrode ◽  
Oxidation Peak ◽  
Modified Glassy Carbon Electrode ◽  
Peak Current ◽  
Oxidation Peak Current ◽  
Antioxidant Capacities

AbstractIn this study, an electrochemical biosensor based on guanine and chitosan immobilized MoS2 nanosheet modified glassy carbon electrode (guanine/CS/MoS2/GCE) was developed and employed for antioxidant screening and antioxidant capacity evaluation. The oxidation peak current of guanine was improved and nearly tripled after modifications of chitosan and MoS2 nanosheet. The immobilized guanine could be damaged by hydroxyl radicals generated in Fenton solution. However, in the presence of antioxidants, the guanine was protected and the oxidation peak current of guanine increased. This process mimics the mechanism of antioxidant protection in human body. The factors affecting preparation of sensor and detection of antioxidant capacity were optimized. At the optimum conditions, the guanine/CS/MoS2/GCE showed wide linear range, low detection limit, satisfactory reproducibility and stability for detection. Ascorbic acid was used as a model antioxidant to evaluate the antioxidant capacity. A good linearity was observed with a correlation coefficient of 0.9959 in the concentrations between 0.5 and 4.0 mg L-1. The antioxidant capacities of three flavonoids were also tested and the rank of antioxidant capacities was ascorbic acid (51.84%), quercetin (45.82%), fisetin (34.39%) and catechin (16.99%). Due to the rapid measurement and low cost, this sensor could provide an available sensing platform for antioxidant screening and evaluation.

A Novel Electrochemical Sensor for the Analysis of Salbutamol in Pork Samples by Using NiFe2O4 Nanoparticles Modified Glassy Carbon Electrode

2013 ◽  
Vol 850-851 ◽  
pp. 1279-1282 ◽  
Author(s):  
Su Xing Luo ◽  
Yuan Hui Wu ◽  
Hua Gou ◽  
Yan Liu
Keyword(s):  
Detection Limit ◽  
Electrochemical Sensor ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Method ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Peak Current ◽  
Anodic Peak Current ◽  
Pork Samples

In this work, a simple and sensitive electrochemical method sensor was developed to determine salbutamol based on magnetic NiFe2O4nanoparticles modified glassy carbon electrode. It was found the anodic peak current of salbutamol was linear with the concentration of salbutamol from 2.0 μM to 60 μM with a detection limit of 1.0 μM (S/N=3). The developed method was successfully applied to determine salbutamol content in pork samples with satisfactory results.

scholarly journals Stripping Voltammetric Determination of Analgesics in Their Pharmaceuticals Using Nano-Riboflavin-Modified Glassy Carbon Electrode

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Gopalakrishnan Gopu ◽  
Paramasivam Manisankar ◽  
Baladhandapani Muralidharan ◽  
Chinnapiyan Vedhi
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Pharmaceutical Preparations ◽  
Sem Analysis ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Diffusion Controlled ◽  
Influence Of Ph

Cyclic voltammetric behaviors of three analgesics, acetaminophen (AAP), acetylsalicylic acid (ASA), and dipyrone (DP), were studied using nano-riboflavin-modified glassy carbon electrode. One well-defined oxidation peak each for AAP and ASA and three oxidation peaks for DP were observed. The influence of pH, scan rate, and concentration reveals irreversible diffusion controlled reaction. The SEM analysis confirmed good accumulation of the drugs on the electrode surface. Calibration was made under the maximum peak current conditions. The concentration range studied for the determination of drugs was 0.02 to 0.4 μg mL−1for AAP and ASA and 0.025 to 0.4 μg mL−1for DP. The lower limit of detection observed for AAP, ASA, and DP was 0.016, 0.007 μg mL−1, and 0.013 μg mL−1, respectively. The suitability of the method for the determination of these analgesics in pharmaceutical preparations and urine samples was also ascertained.

Preparation and characterization of a poly-o-phenylenediamine film modified glassy carbon electrode as a H2O2 sensor

2013 ◽  
Vol 91 (11) ◽  
pp. 1077-1084 ◽  
Author(s):  
Wenying Zhai ◽  
Xiuying Tian ◽  
Yun Yan ◽  
Yuehua Xu ◽  
Yuechun Zhao ◽  
...  
Keyword(s):  
Cyclic Voltammetry ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Impedance ◽  
Monomer Concentration ◽  
Acetate Buffer ◽  
Acetate Buffer Solution ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Buffer Solution

A poly-o-phenylenediamine film modified glassy carbon electrode (PoPD/GC) was successfully prepared by cyclic voltammetry in acetate buffer solution. The polymerization mechanism of oPD is discussed. The impedance behavior and morphology of the PoPD membrane were characterized using cyclic voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy, respectively. It is discovered that the PoPD/GC prepared only in acetate buffer solution had dual electrocatalytic activity toward the oxidation and reduction of H2O2. The optimal buffer solution pH, scanning rate, monomer concentration, and number of scannings for film forming were 4.2, 0.05 V s−1, 6.0 mmol L−1, and 30, respectively. The linear ranges between the anodic (Δia) or cathodic (Δic) current and H2O2 concentration were 0.07−1.0 × 104 and 0.04−4.5 × 104 μmol L−1, respectively. The corresponding calibration curves were Δia (μA) = 8.03c (mmol L−1) + 6.36 (n = 18, R2 = 0.9989) and Δic (μA) = −5.52c (mmol L−1) − 0.77 (n = 18, R2 = 0.9990) with a detection limit of 0.03 and 0.02 μmol L−1 (S/N = 3), respectively. The PoPD/GC prepared in the optimal conditions showed good stability and quick response (<0.2 s) to H2O2, which was successfully applied to the determination of H2O2 in real water samples with satisfactory results.

Electrocatalytic redox behavior of graphene films towards acebutolol hydrochloride determination in real samples

2016 ◽  
Vol 40 (4) ◽  
pp. 3763-3772 ◽  
Author(s):  
Atmanand M. Bagoji ◽  
Sharanappa T. Nandibewoor
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Graphene Film ◽  
Carbon Electrode ◽  
Redox Behavior ◽  
Optimal Conditions ◽  
Modified Glassy Carbon Electrode ◽  
Real Samples ◽  
Graphene Films

Under optimal conditions, a graphene film modified glassy carbon electrode exhibited a longer linearity range from 3.36 to 57.12 ng mL−1 of acebutolol with a limit of detection of 0.131 ng mL−1.

scholarly journals Voltammetric determination of dopamine in the presence of ascorbic and uric acids using partial least squares regression: determination of dopamine in human urine and plasma

2009 ◽  
Vol 7 (3) ◽  
pp. 524-531 ◽  
Author(s):  
Morteza Bahram ◽  
Khalil Farhadi ◽  
Farzin Arjmand
Keyword(s):  
Least Squares ◽  
Partial Least Squares ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Relative Standard Error ◽  
Carbon Electrode ◽  
Least Squares Regression ◽  
Relative Standard

AbstractA new differential pulse voltammetric method for dopamine determination at a bare glassy carbon electrode has been developed. Dopamine, ascorbic acid (AA) and uric acid (UA) usually coexist in physiological samples. Because AA and UA can be oxidized at potentials close to that of DA it is difficult to determine dopamine electrochemically, although resolution can be achieved using modified electrodes. Additionally, oxidized dopamine mediates AA oxidation and the electrode surface can be easily fouled by the AA oxidation product. In this work a chemometrics strategy, partial least squares (PLS) regression, has been applied to determine dopamine in the presence of AA and UA without electrode modification. The method is based on the electrooxidation of dopamine at a glassy carbon electrode in pH 7 phosphate buffer. The dopamine calibration curve was linear over the range of 1–313 μM and the limit of detection was 0.25 μM. The relative standard error (RSE %) was 5.28%. The method has been successfully applied to the measurement of dopamine in human plasma and urine.

scholarly journals Electrocatalysis of a SiC particle-modified glassy carbon electrode for the oxidation of adrenaline in a KRPB physiological solution

2005 ◽  
Vol 70 (5) ◽  
pp. 745-752 ◽  
Author(s):  
Zhang-Yu Yu ◽  
De-Sheng Kong ◽  
Shu-Xin Wu ◽  
Lei Wang ◽  
Hanf-Qing Wang
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Impedance ◽  
Electrochemical Reaction ◽  
Physiological Solution ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Adsorption Effect ◽  
Electrocatalytic Effect ◽  
Sic Particle

The electrocatalytic properties of a SiC particle-modified glassy carbon electrode (MGC) for adrenaline oxidation were studied by cyclic voltammetry, double-potential step chronoculometry and electrochemical impedance spectroscopy in a pH 7.4 physiological Kres?Ringer phosphate buffer (KRPB) solution. It was shown that modification of the electrode with SiC particles has a marked electrocatalytic effect on the electrochemical reaction of adrenaline, i.e., the activity and the reversibility of the MGC electrode were significantly improved compared to an unmodified electrode. This was attributed to the adsorption effect of the electroactive adrenaline molecules on the MGC electrode surface. .

PAn/Cu Bismuthate Nanoflake Composites with Enhanced Electrochemical Performance for TA

2020 ◽  
Vol 12 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Z. Wang ◽  
H.J. Chen ◽  
F.F. Lin ◽  
L. Yan ◽  
Y. Zhang ◽  
...  
Keyword(s):  
Cyclic Voltammetry ◽  
Electrochemical Performance ◽  
Tartaric Acid ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Enhanced Electrochemical Performance

Background: Measuring tartaric acid in liquid food, such as fruits or fruit products is of great importance for assessing the quality of the food. Objective: The aim of the research is to obtain polyaniline/Cu bismuthate nanoflake composites by an in-situ polymerization route for the electrochemical detection of tartaric acid. Methods: Polyaniline/Cu bismuthate nanoflake composites were prepared by in-situ aniline polymerizing route in aqueous solution. The obtained products were characterized by X-Ray diffraction (XRD), Transmission Electron Microscopy (TEM) and high-resolution TEM (HRTEM), respectively. The electrochemical performance for tartaric acid detection has been investigated by cyclic voltammetry method using polyaniline/Cu bismuthate nanoflake composites modified glassy carbon electrode. Results: The nanocomposites comprise of tetragonal CuBi2O4 phase. Polyaniline particles with the size of less than 100 nm attach to the surface of the nanoflakes. A pair of quasi-reversible cyclic voltammetry peaks are located at -0.01 V and +0.04 V, respectively at the 20wt.% polyaniline/Cu bismuthate nanoflake composites modified glassy carbon electrode. The limit of detection is 0.58 µM with the linear range of 0.001-2 mM. The linear range increases from 0.005-2 mM to 0.001-2 mM and limit of detection decreases from 2.3 µM to 0.43 µM with increasing the polyaniline content from 10wt.% to 40wt.%. Conclusion: Comparing with the Cu bismuthate nanoflakes modified glassy carbon electrode, polyaniline/ Cu bismuthate nanoflake composites modified glassy carbon electrode shows enhanced electrochemical performance for tartaric acid detection.

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