scholarly journals Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst

2018 ◽  
Vol 61 (1) ◽  
pp. 17-21
Author(s):  
Zohreh Jaafari-Ashkavandi ◽  
Ahmad Alipour Tuyeh ◽  
Sepideh Assar
Keyword(s):  
Dentigerous Cyst ◽  
Odontogenic Cysts ◽  
Radicular Cyst ◽  
Immunohistochemical Expression ◽  
Serine Threonine Kinase ◽  
Threonine Kinase ◽  
Dentigerous Cysts ◽  
Pathologic Lesions ◽  
The Mean ◽  
Post Hoc

CDC7 is a serine/threonine kinase which has an essential role in initiation of DNA proliferation and S phase. It increases the invasion and proliferation in many pathologic lesions. This study aimed to evaluate the expression of CDC7 in the most common odontogenic cysts. We evaluated 17 dentigerous cysts, 18 odontogenic keratocysts (OKC) and 13 radicular cysts immunohistochemically. The mean expression of CDC7 was analyzed using ANOVA and Post-HOC methods. All specimens revealed CDC7 expression. Higher expression of CDC7 in OKC and radicular cyst was shown in comparison to dentigerous cyst (P < 0.001), while radicular cyst and OKC groups showed no difference in CDC7 expression (P = 0.738). The high expression of CDC7 in OKC suggests that this protein could be related to the higher proliferation rate and invasiveness of OKC. On the other hand, the higher CDC7 expression in radicular cyst may simply be related to inflammation as this cyst is neither aggressive nor invasive.

Evaluation of Radiolucent Lesions Associated with Impacted Teeth: A Retrospective Study

2020 ◽  
Vol 16 ◽  
Author(s):  
Hulya Cakir Karabas ◽  
Ilknur Ozcan ◽  
Merva Soluk Tekkesin ◽  
Sedef Ayse Tasyapan ◽  
Beliz Guray ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Dentigerous Cyst ◽  
Pathological Diagnosis ◽  
Odontogenic Cysts ◽  
Histopathological Diagnosis ◽  
Impacted Teeth ◽  
Dentigerous Cysts ◽  
Pathologic Lesions ◽  
Detailed Imaging ◽  
Age And Sex

Background: Impacted teeth are commonly asymptomatic and not associated with any pathologic lesions for years. Any change in the size of the follicle associated with impacted teeth may result in odontogenic cysts or tumors. CBCT plays an important role in determining the radiographic features of a lesion and therefore, is very helpful for accurate diagnosis and treatment planning. Objective: This study aims to evaluate radiolucent lesions associated with impacted teeth in terms of age and sex distribution, localization, and comparison with the pathological diagnosis. Method: In this retrospective study, out of 6758 CBCT images, 400 images revealing radiolucent lesions were detected. The study included only 190 cases (regarding 180 patients) which had a matching histopathological evaluation. Data related to the age and sex of the patients, localization of the lesions, and comparison of them with the pathological diagnosis were recorded and analyzed. Results: The most encountered lesions were dentigerous cysts (60%) and odontogenic keratocysts (26.3%). Males were most affected (63.3%). Most of the lesions were found in the left and right posterior mandible and mostly (66.8 %) associated with third molars. Out of 123 radiological diagnoses of dentigerous cyst cases, histopathological diagnoses confirmed 108 cases. Regarding odontogenic keratocyst, histopathological diagnosis confirmed 40 cases out of 48. Conclusion: Radiological diagnoses of the lesions mostly match with their pathological diagnosis unless their characteristics are changed due to infection. CBCT, as a technique enabling detailed imaging of the involved dental structures, is a helpful instrument for differential diagnosis.

scholarly journals MASSIVE DENTIGEROUS CYST INVOLVING THE ENTIRE RIGHT MAXILLA - A CASE REPORT

2019 ◽  
pp. 1-2
Author(s):  
K. S Manjunath
Keyword(s):  
Case Report ◽  
Dentigerous Cyst ◽  
Odontogenic Cyst ◽  
Odontogenic Cysts ◽  
Radicular Cyst ◽  
Impacted Tooth ◽  
Unerupted Tooth ◽  
Dentigerous Cysts ◽  
Enamel Epithelium ◽  
Reduced Enamel Epithelium

The Dentigerous cysts are odontogenic cysts which originates from reduced enamel epithelium in an unerupted tooth or it encloses the crown of an unerupted or impacted tooth at cementoenamel junction, it is estimated to about 20% of all epithelium lined cysts and 2nd most common odontogenic cyst after radicular cyst. Here is a case report of dentigerous cyst of right maxilla which has been discussed below.

scholarly journals Cistos e tumores odontogênicos: estudo retrospectivo dos casos diagnosticados no período de 10 anos em um hospital no sul do Brasil

2021 ◽  
Vol 62 (1) ◽  
pp. 56-62
Author(s):  
Bruna Luísa Neumann ◽  
Stéfanie Thieme ◽  
Amanda De Farias Gabriel ◽  
Virgilio Gonzales Zanella ◽  
Felipe Martins Silveira ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Medical Records ◽  
Dentigerous Cyst ◽  
Odontogenic Tumors ◽  
Odontogenic Cysts ◽  
Histopathological Diagnosis ◽  
Radicular Cyst ◽  
Pathological Characteristics ◽  
The Mean ◽  
Odontogenic Neoplasm

Introduction: odontogenic lesions (OLs) represent a heterogeneous group of oral and maxillofacial pathologies presenting distinct characteristics. The present study aimed to identify the clinical and pathological characteristics of OLs diagnosed in a southern Brazilian hospital. Materials and methods: a retrospective study was performed to evaluate cases with histopathological diagnosis of OLs identified in the period between 2007 and 2017. The patient's medical records were evaluated in order to obtain the clinical and pathological characteristics and the histopathological diagnosis from each case. Results: a total of 255 cases of OLs were identified. From these, 197 (77%) odontogenic cysts and 58 (23%) odontogenic tumors were surveyed, with only one case (0,39%) of a malignant odontogenic neoplasm. The most prevalent diagnosis were radicular cyst (32.5%) and dentigerous cyst (31.76%), followed by odontogenic keratocyst (10.98%), odontoma (10%) and ameloblastoma (10%). The majority of the cases affected the mandible (53.7%) with a slight preference by female individuals (51%). The mean age was 34±20.53 years old. Discussion: the presented data are in accordance with the literature regarding the rarity of the diagnosis of odontogenic tumors. Conclusion: the present study demonstrated the main clinical and pathological characteristics of OLs diagnosed in a southern Brazilian hospital, contributing to a better understanding of these injuries profiles.

Clinico-Radiological Study of Odontogenic Cysts in Mandibular Region from Agartala, Tripura

2021 ◽  
Vol 8 (37) ◽  
pp. 3350-3355
Author(s):  
Amit Lal Goswami ◽  
Manik Saha
Keyword(s):  
Dentigerous Cyst ◽  
Case Series ◽  
Odontogenic Cysts ◽  
Cystic Lesions ◽  
Radicular Cyst ◽  
Medical College ◽  
Dentigerous Cysts ◽  
Mandibular Region ◽  
Common Variety ◽  
Age Range

BACKGROUND Most common osseous destructive lesions effecting the jawbone are odontogenic cystic lesions, which are lined by epithelium, has been involved in the formation of teeth as the epithelial cell rest are present in jawbone after teeth formation. The three most common odontogenic cysts (OCs) are radicular cyst (RC), dentigerous cyst (DC) and the odontogenic keratocyst (OKC). Less common variety is the residual cyst. Odontogenic cysts are mainly developmental and inflammatory in origin. The objective of the present study was to find clinico-radiographic characteristics of odontogenic cysts in the mandible. METHODS This was a case series (descriptive) study on OCs of mandible conducted at Tripura Medical College and Dr BRAM Teaching Hospital, Hapania, Agartala, Tripura (W), India, over a period of 6 months from August 2019 to January 2020. Subjects showing clinico-radiographic features of OCs in mandible were included, subsequently confirmed by histopathological examinations. Usually orthopantomograms (OPGs) and intra oral peri apical radiograph (IOPAs) were done for radiological findings, computed tomography (CT) scan was required for examination of the size of lesion. Data were analysed using windows excel. RESULTS Diagnosis of OCs was confirmed in 20 patients, among them, males were (60 %) and female were (40 %). The age range of the patients was 17 - 65 years. Most common type of cyst diagnosed in the study was radicular cyst in 50 % cases followed by dentigerous cysts which were in 30 % cases, odontogenic keratocysts were in 15 % patients and others were 5 %. RCs were represented in higher percentage (50 %). Right side of mandible was the most effected side (60 %) than left side (40 %). Main finding of the study was, in every type of cystic lesions, males were recorded as predominant, and it occurred in early age group. CONCLUSIONS Main finding of the study was radicular cyst which was in higher percentage (50 %) and was being most common with association of carious tooth. KEYWORDS Odontogenic Cysts, Mandible, Finding

scholarly journals Odontogenic Cysts and Tumors of Maxilla and Maxillary Sinus (A Clinicopathological Analysis)

2021 ◽  
Vol 33 (4) ◽  
pp. 38-43
Author(s):  
Shahad A Waheed ◽  
Taghreed F Zaidan ◽  
Bashar H Abdullah
Keyword(s):  
Maxillary Sinus ◽  
Dentigerous Cyst ◽  
Clinicopathological Features ◽  
Odontogenic Cysts ◽  
Radicular Cyst ◽  
Impacted Tooth ◽  
Clinicopathological Analysis ◽  
Male Patients ◽  
The Mean ◽  
Similarities And Differences

Background: Knowledge about the prevalence and distribution of pathologies in a particular location is important when a differential diagnosis is being formulated. The aim of this study was to describe the prevalence and the clinicopathological features of odontogenic cysts and tumors affecting the maxilla and to discuss the unusual presentation of those lesions within maxillary sinus. Materials and Methods: A multicenter retrospective analysis was performed on pathology archives of patients who were diagnosed with maxillary odontogenic cysts and tumors from 2010 to 2020. Data were collected with respect to age, gender and location. Result: A total of 384 cases was identified, 320 (83.3%) cases were diagnosed as odontogenic cysts and 64 (16.6%) as odontogenic tumors. The mean age was 30.5 years with a standard deviation of 16.2 years. Male patients were more commonly affected (n=220, 57.3%). Radicular cyst was the most common cyst (n=205, 64.1%), while the most common tumor was odontoma (n=14, 21.9%) and dentigerous cyst was the most common lesion to present within the maxillary sinus. Conclusion: This study indicates that there are some geographic similarities and differences in regard to distribution of odontogenic cysts and tumors in maxilla and it raises awareness of their presentation within maxillary sinus especially if there is an association with an ectopic or adjacent impacted tooth.

scholarly journals Differential Expression of Claudin in Odontogenic Cysts

2021 ◽  
Author(s):  
Ekarat Phattarataratip ◽  
Kraisorn Sappayatosok
Keyword(s):  
Pairwise Comparison ◽  
Odontogenic Cyst ◽  
Odontogenic Cysts ◽  
Positive Staining ◽  
Pathogenic Role ◽  
Dentigerous Cysts ◽  
Different Types ◽  
Level Of Significance ◽  
Post Hoc ◽  
Spearman’S Correlation

Abstract Objective This study aimed to analyze claudin-1, -4, and -7 expression in different types of odontogenic cysts (odontogenic keratocysts [OKCs], dentigerous cysts [DCs], calcifying odontogenic cysts [COCs], and radicular cysts [RCs]) as well as its association with OKC recurrence. Materials and Methods Seventy samples of odontogenic cysts samples were immunohistochemically stained to detect claudin-1, -4, and -7 expression. Patient information and OKC recurrence data were recorded. The staining was analyzed semiquantitatively and categorized based on the pattern and percentage of positively stained cystic epithelial cells. Statistical Analysis Expression of different claudins between groups was analyzed using the Kruskal–Wallis test with Dunn's test, followed by post hoc pairwise comparison. The association between claudin expression and OKC recurrence was analyzed by the Mann–Whitney U test. Correlations among claudin expression were examined with Spearman's correlation coefficient. Level of significance was at p < 0.005. Results Claudin-1 was widely expressed in every odontogenic cyst. Most DCs (50%) expressed claudin-1 in more than 75% of cells, as did RCs (65%), while most OKCs (50%) expressed claudin-1 in 26 to 50% of cells. Most COCs (50%) expressed claudin-1 in 51 to 75% of cells. Every sample of OKC and RC was positive for claudin-4, but no sample showed staining in more than 51% of cells. Every odontogenic cyst was positive for claudin-7. DCs (35%), OKCs (55%), and RCs (40%) mostly showed staining in 26 to 50% of cells. High claudin-1 expression was shown in COCs, DCs, and RCs, while low expression of claudin-4 was shown in every odontogenic cyst. For claudin-7, the expression is high only in COCs. Claudin-1 and -4 was significantly different among each odontogenic cyst. High expression of claudin-1 was correlated with OKC recurrence. The correlations of claudin-1 with claudin-7 expression and claudin-4 with claudin-7 expression were significant in DCs. In COCs, claudin-1 and claudin-7 expression was significantly correlated. Conclusions The expression of claudin-1, -4, and -7 was present in every odontogenic cyst, but the proportion of positive staining cells was different. Expression of claudin-1 is associated with OKC recurrence. Dysregulation of claudin expression may play a pathogenic role in cyst pathogenesis.

scholarly journals The correlation between the three-dimensional radiolucency area around the crown of impacted maxillary canines and dentigerous cysts

2020 ◽  
Vol 49 (4) ◽  
pp. 20190402
Author(s):  
Junliang Chen ◽  
Dongmei Lv ◽  
MingXia Li ◽  
Wei Zhao ◽  
Yun He
Keyword(s):  
Cone Beam Ct ◽  
Dentigerous Cyst ◽  
Three Dimensional ◽  
Cone Beam ◽  
Hard Tissue ◽  
Mean Values ◽  
Dentigerous Cysts ◽  
Impacted Canine ◽  
The Mean ◽  
Surgical Operations

This study aimed to reveal the correlation between the radiolucency area around the crown of impacted maxillary canines and dentigerous cysts using cone beam CT (CBCT). CBCT data were obtained from patients with impacted maxillary canines. Three points of five areas (tooth cusp area and buccal, lingual, mesial and distal areas of the crown) were randomly selected, and the distance between the point and the surrounding hard tissue was measured respectively. The mean values were recorded as the radiolucency area. These results were compared with the occurrence of dentigerous cysts during surgery. 58 patients with 76 impacted maxillary canines were included. 14 of the 76 impacted canines were accompanied by cysts (18.42%). With the increase in the thickness of the radiolucency area, the incidence of cysts was significantly increased (p < 0.05). No cysts were found in the compacted canines with 0–1 mm thickness of the radiolucency area. The highest incidence (71.43%) was observed in canines with 3–4 mm thickness of the radiolucency area. This study found that the thickness of the radiolucency area around the crown of the maxillary impacted canine was closely related to the occurrence of dentigerous cysts. CBCT can be used to estimate the occurrence possibility of dentigerous cyst and guide surgical operations.

Retrospective 3D analysis of bone regeneration after cystectomy of odontogenic cysts

2020 ◽  
Vol 28 (6) ◽  
pp. 1141-1155
Author(s):  
Mayte Buchbender ◽  
Birte Koch ◽  
Marco Rainer Kesting ◽  
Ragai Edward Matta ◽  
Werner Adler ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Computer Tomography ◽  
Evaluation Method ◽  
Defect Size ◽  
Odontogenic Cysts ◽  
3D Analysis ◽  
Dentigerous Cysts ◽  
The Mean ◽  
3D Evaluation

BACKGROUND/OBJECTIVE: In this retrospective study, we aimed to investigate a new 3D evaluation method for evaluating bone regeneration after cystectomy of odontogenic cysts. METHODS: The study included 26 patients who underwent cystectomies between 2012 and 2017 and had received either fillings or non-fillings with autologous iliac crest. Bony regeneration was analyzed using 3D imaging software and comparing identical regions of interest (ROIs) that were determined by exact overlays of the postoperative cone beam computer tomography (CBCT) or computer tomography (CT) images. Outcome measures, including volume changes according to the defect size and configuration, patient age, the entity and distribution of the cysts, were collected. RESULTS: Twenty-six patients (5 women and 21 men) had 30 defects, including nine keratocysts, seven radicular cysts and 14 dentigerous cysts. A total of 73% of the defects were in the mandible. The mean 3D follow-up time was 12 months. According to the 3D evaluation of bony regeneration, the defect size and configuration showed no significant differences between the groups (filled or non-filled with 15 defects per group). CONCLUSIONS: By establishing a standardized 3D method for evaluating bone regeneration, healing can be better monitored and evaluated.

Giant dentigerous cyst occupying the right hemimandible

2002 ◽  
Vol 10 (4) ◽  
pp. 171-174
Author(s):  
Uğur Koçer ◽  
H Mete Aksoy ◽  
YiğIt Ö TiftikçioğLu ◽  
Dilek Ertoy ◽  
Önder Karaaslan
Keyword(s):  
Young Patient ◽  
Bone Grafting ◽  
Present Report ◽  
Dentigerous Cyst ◽  
Odontogenic Cysts ◽  
Surgical Removal ◽  
Dentigerous Cysts ◽  
Primary Bone ◽  
The Right

Dentigerous cysts are the second most common odontogenic cysts of the mandible. They may vary in size from 2 cm to more than 10 cm. In the present report, a dentigerous cyst with massive involvement of the right half of the mandible in a young patient is presented. For cosmetic reasons and long term risks these cysts must be treated. Surgical removal is the preferred modality and a submandibular route should be chosen in large lesions. Bony cavities may be decreased in volume by using osteoperiosteal flaps, but there is no need for primary bone grafting, even for large defects.

scholarly journals Bilateral Maxillary Dentigerous Cysts in a Nonsyndromic Child: A Rare Presentation and Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Rakshit Vijay Khandeparker ◽  
Purva Vijay Khandeparker ◽  
Anirudha Virginkar ◽  
Kiran Savant
Keyword(s):  
Dentigerous Cyst ◽  
Permanent Teeth ◽  
Deciduous Teeth ◽  
Odontogenic Cysts ◽  
Systemic Diseases ◽  
Review Of The Literature ◽  
Rare Presentation ◽  
Dentigerous Cysts ◽  
The Right

Dentigerous cysts represent the second most common odontogenic cysts of the jaws after radicular cysts and are usually associated with the crowns of unerupted permanent teeth and rarely deciduous teeth. They are usually solitary in their presentation. Multiple and bilateral dentigerous cysts are an extremely rare presentation in the absence of developmental syndromes or systemic diseases or the use of prescribed certain medications. We hereby present a case of a bilateral dentigerous cyst of the maxilla in a 10-year-old child involving the crowns of unerupted permanent second premolar on the right side and the unerupted permanent canine on the left side. An effort has also been made to review the existing literature on this entity and to stress the importance of radiographic and histopathological examinations in diagnosing such an entity.

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