Dynamical Relation of Poisson Spike Trains In Hodkin-Huxley Neural Ion Current Model and Formation of Non-Canonical Bases, Islands, and G-quadruplexes in DNA, mRNA, and RNA at or near the Transcription.

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Michael Fundator
Author(s):  
Michael Fundator

Ground breaking application of mathematics and biochemistry to explain formation of non-canonical bases, islands, G-quadruplex structures, and analog bases in DNA and mRNA at or near the transcription with connection to neural networks is implemented using statistical and stochastic methods apparatus with the addition of quantum principles. As a result the usual transience of Poisson spike trains (PST) becomes very instrumental tool for finding periodical type of solutions to Fokker-Plank (FP) stochastic differential equation (SDE). The present study develops new multidimensional methods of finding solutions to SDE. This is based on more rigorous approach to mathematical apparatus through Kolmogorov-Chentsov continuity theorem (KCCT) that allows the stochastic processes with jumps under certain conditions to have  γ-Holder continuous modification, which is used as basis for finding analogous parallels in dynamics of formation of CpG and non-CpG islands (CpGI or non CpGI), repeats of G-quadruplexes, and non canonical bases during DNA (de)- methylation and neural networks.


2001 ◽  
Vol 89 (11) ◽  
pp. 5932-5938 ◽  
Author(s):  
Deepak Bose ◽  
T. R. Govindan ◽  
M. Meyyappan

Author(s):  
Irwin Bendet ◽  
Nabil Rizk

Preliminary results reported last year on the ion etching of tobacco mosaic virus indicated that the diameter of the virus decreased more rapidly at 10KV than at 5KV, perhaps reaching a constant value before disappearing completely.In order to follow the effects of ion etching on TMV more quantitatively we have designed and built a second apparatus (Fig. 1), which incorporates monitoring devices for measuring ion current and vacuum as well as accelerating voltage. In addition, the beam diameter has been increased to approximately 1 cm., so that ten electron microscope grids can be exposed to the beam simultaneously.


Author(s):  
M. Spector ◽  
A. C. Brown

Ion beam etching and freeze fracture techniques were utilized in conjunction with scanning electron microscopy to study the ultrastructure of normal and diseased human hair. Topographical differences in the cuticular scale of normal and diseased hair were demonstrated in previous scanning electron microscope studies. In the present study, ion beam etching and freeze fracture techniques were utilized to reveal subsurface ultrastructural features of the cuticle and cortex.Samples of normal and diseased hair including monilethrix, pili torti, pili annulati, and hidrotic ectodermal dysplasia were cut from areas near the base of the hair. In preparation for ion beam etching, untreated hairs were mounted on conducting tape on a conducting silicon substrate. The hairs were ion beam etched by an 18 ky argon ion beam (5μA ion current) from an ETEC ion beam etching device. The ion beam was oriented perpendicular to the substrate. The specimen remained stationary in the beam for exposures of 6 to 8 minutes.


Author(s):  
M. Shlepr ◽  
R. L. Turner

Calcification in the echinoderms occurs within a limited-volume cavity enclosed by cytoplasmic extensions of the mineral depositing cells, the sclerocytes. The current model of this process maintains that the sheath formed from these cytoplasmic extensions is syncytial. Prior studies indicate that syncytium formation might be dependent on sclerocyte density and not required for calcification. This model further envisions that ossicles formed de novo nucleate and grow intracellularly until the ossicle effectively outgrows the vacuole. Continued ossicle growth occurs within the sheath but external to the cell membrane. The initial intracellular location has been confirmed only for elements of the echinoid tooth.The regenerating aboral disc integument of ophiophragmus filograneus was used to test the current echinoderm calcification model. This tissue is free of calcite fragments, thus avoiding questions of cellular engulfment, and ossicles are formed de novo. The tissue calcification pattern was followed by light microscopy in both living and fixed preparations.


1997 ◽  
Vol 92 (3) ◽  
pp. 609-617 ◽  
Author(s):  
RICCARDO ZANASI ◽  
PAOLO LAZZERETTI

2000 ◽  
Vol 12 (1) ◽  
pp. 65-86 ◽  
Author(s):  
R. La ◽  
B. Benoist ◽  
B. de Barmon ◽  
M. Talvard ◽  
R. Lengelle ◽  
...  

1957 ◽  
Vol 2 (6) ◽  
pp. 153-155
Author(s):  
W. K. ESTES
Keyword(s):  

1976 ◽  
Vol 73 ◽  
pp. 436-440 ◽  
Author(s):  
Jan A. Herman ◽  
Janusz Gawlowski
Keyword(s):  

2013 ◽  
Vol 1 (3) ◽  
pp. 9
Author(s):  
Jennifer Lee Brady ◽  
Annie Hoang ◽  
Olivia Siswanto ◽  
Jordana Riesel ◽  
Jacqui Gingras

Obtaining dietetic licensure in Ontario requires completion of a Dietitians of Canada (DC) accredited four-year undergraduate degree in nutrition and an accredited post-graduate internship or combined Master’s degree program. Given the scarcity of internship positions in Ontario, each year approximately two-thirds of the eligible applicants who apply do not receive a position XX, XX, XX, XX, XX, XX, in press). Anecdotally, not securing an internship position is known to be a particularly disconcerting experience that has significant consequences for individuals’ personal, financial, and professional well-being. However, no known empirical research has yet explored students’ experiences of being unsuccessful in applying for internship positions. Fifteen individuals who applied between 2005 and 2009 to an Ontario-based dietetic internship program, but were unsuccessful at least once, participated in a one-on-one semi-structured interview. Findings reveal that participants’ experiences unfold successively in four phases that are characterized by increasingly heightened emotional peril: naïveté, competition, devastation, and frustration. The authors conclude that the current model of dietetic education and training in Ontario causes lasting distress to students and hinders the future growth and vitality of the dietetic profession. Further research is required to understand the impact of the current model on dietetic educators, internship coordinators, and preceptors as coincident participants in the internship application process.


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