scholarly journals Metformin Regulates the Inflammatory Response of Human Monocytes to SARS-CoV-2 Spike Glycoprotein

2021 ◽  
Vol 6 (3) ◽  
pp. 82-85
Author(s):  
Madeleine Morris ◽  
Albert Chung ◽  
Matthew Palfreeman ◽  
Jose Barragan ◽  
Jorge Cervantes
Keyword(s):  
Inflammatory Response ◽  
Human Monocytes ◽  
Spike Glycoprotein

scholarly journals In Vivo Exposure to High or Low Cortisol Has Biphasic Effects on Inflammatory Response Pathways of Human Monocytes

2008 ◽  
Vol 107 (5) ◽  
pp. 1726-1734 ◽  
Author(s):  
Mark P. Yeager ◽  
Patricia A. Pioli ◽  
Kathleen Wardwell ◽  
Michael L. Beach ◽  
Peter Martel ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Human Monocytes ◽  
Low Cortisol

Role of MMPs in orchestrating inflammatory response in human monocytes via a TREM-1-PI3K-NF-κB pathway

2012 ◽  
Vol 91 (6) ◽  
pp. 933-945 ◽  
Author(s):  
Vanesa Gómez-Piña ◽  
Eriel Martínez ◽  
Irene Fernández-Ruíz ◽  
Carlos del Fresno ◽  
Alessandra Soares-Schanoski ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Human Monocytes

scholarly journals Transcriptomic Profiling of the Development of the Inflammatory Response in Human Monocytes In Vitro

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e87680 ◽  
Author(s):  
Paola Italiani ◽  
Emilia M. C. Mazza ◽  
Davide Lucchesi ◽  
Ingrid Cifola ◽  
Claudia Gemelli ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Human Monocytes ◽  
Transcriptomic Profiling

scholarly journals Erratum: Corrigendum: Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Nicholas E. Ilott ◽  
James A. Heward ◽  
Benoit Roux ◽  
Eleni Tsitsiou ◽  
Peter S. Fenwick ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Human Monocytes ◽  
Non Coding Rnas

scholarly journals Gene Expression Pattern in Human Monocytes as a Surrogate Marker for Systemic Inflammatory Response Syndrome (SIRS)

1999 ◽  
Vol 5 (3) ◽  
pp. 192-202 ◽  
Author(s):  
Grit Wiegand ◽  
Kathleen Selleng ◽  
Matthias Gründling ◽  
Robert S. Jack
Keyword(s):  
Gene Expression ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Expression Pattern ◽  
Gene Expression Pattern ◽  
Surrogate Marker ◽  
Systemic Inflammatory Response ◽  
Human Monocytes

scholarly journals SARS-CoV-2 induces inflammasome-dependent pyroptosis and downmodulation of HLA-DR in human monocytes

2020 ◽  
Author(s):  
André C. Ferreira ◽  
Vinicius Cardoso Soares ◽  
Isaclaudia G. de Azevedo-Quintanilha ◽  
Suelen da Silva Gomes Dias ◽  
Natalia Fintelman-Rodrigues ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Severe Acute Respiratory Syndrome ◽  
Inflammatory Response ◽  
Inflammatory Cell ◽  
Viral Infections ◽  
Relevant Information ◽  
Inflammasome Activation ◽  
Human Monocytes ◽  
Hla Dr

AbstractInfection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for the identification of therapies capable to control the hyper-inflammation and reduce viral replication in patients with COVID-19. Here, we show that SARS-CoV-2 induces inflammasome activation and cell death by pyroptosis in human monocytes, experimentally infected and from patients under intensive care. Pyroptosis was dependent on caspase-1 engagement, prior to IL-1ß production and inflammatory cell death. Monocytes exposed to SARS-CoV-2 downregulate HLA-DR, suggesting a potential limitation to orchestrate the immune response. Our results originally describe mechanisms by which monocytes, a central cellular component recruited from peripheral blood to respiratory tract, succumb to control severe 2019 coronavirus disease (COVID-19).Author summarySince its emergence in China in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused thousands of deaths worldwide. Currently, the number of individuals infected with SARS-CoV-2 and in need of antiviral, anti-inflammatory, anticoagulant and more invasive treatments has overwhelmed the health systems worldwide. In our study, we found that SARS-CoV-2 is capable of inducing inflammatory cell death in human monocytes, one of the main cell types responsible for anti-SARS-CoV-2 immune response. As a consequence of this intracellular inflammatory mechanism (inflammasome engagement), an exacerbated production of inflammatory mediators occurs. The infection also decreases the expression of HLA-DR in monocytes, a molecule related to the orchestration of the immune response in case of viral infections. We also demonstrated that the HIV-1 protease inhibitor, atazanavir (ATV), prevented the uncontrolled inflammatory response, cell death and reduction in HLA-DR expression in SARS-CoV-2-infected monocytes. Our study provides relevant information on the effects of SARS-CoV-2 infection on human monocytes, as well as on the effect of ATV in preventing these pathological effects on the host.

Mo1137 HDAC3 MEDIATES THE INFLAMMATORY RESPONSE AND LPS TOLERANCE IN HUMAN MONOCYTES AND MACROPHAGES

2020 ◽  
Vol 158 (6) ◽  
pp. S-800
Author(s):  
Mohammed Ghiboub ◽  
Jing Zhao ◽  
Andrew Y. Li Yim ◽  
Ronald Schilderink ◽  
Caroline Verseijden ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Human Monocytes ◽  
Monocytes And Macrophages ◽  
Human Monocytes And Macrophages

scholarly journals Biofilm forming P. aeruginosa induces an enhanced inflammatory response in human monocytes

Critical Care ◽  
2007 ◽  
Vol 11 (Suppl 4) ◽  
pp. P26
Author(s):  
Cristina Ciornei ◽  
Christophe Beloin ◽  
Alexey Novikov ◽  
Martine Caroff ◽  
Catherine Fitting ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Human Monocytes

scholarly journals MiR-146b Mediates Endotoxin Tolerance in Human Phagocytes

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Tiziana Ada Renzi ◽  
Marcello Rubino ◽  
Laura Gornati ◽  
Cecilia Garlanda ◽  
Massimo Locati ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Inflammatory Response ◽  
Innate Immune Response ◽  
Endotoxin Tolerance ◽  
Innate Immune ◽  
Human Monocytes ◽  
Key Factors ◽  
Tlr Signaling ◽  
Tolerant State

A proper regulation of the innate immune response is fundamental to keep the immune system in check and avoid a chronic status of inflammation. As they act as negative modulators of TLR signaling pathways, miRNAs have been recently involved in the control of the inflammatory response. However, their role in the context of endotoxin tolerance is just beginning to be explored. We here show that miR-146b is upregulated in human monocytes tolerized by LPS, IL-10, or TGFβpriming and demonstrate that its transcription is driven by STAT3 and RUNX3, key factors downstream of IL-10 and TGFβsignaling. Our study also found that IFNγ, known to revert LPS tolerant state, inhibits miR-146b expression. Finally, we provide evidence that miR-146b levels have a profound effect on the tolerant state, thus candidating miR-146b as a molecular mediator of endotoxin tolerance.

Lactic acid delays the inflammatory response of human monocytes

2015 ◽  
Vol 457 (3) ◽  
pp. 412-418 ◽  
Author(s):  
Katrin Peter ◽  
Michael Rehli ◽  
Katrin Singer ◽  
Kathrin Renner-Sattler ◽  
Marina Kreutz
Keyword(s):  
Lactic Acid ◽  
Inflammatory Response ◽  
Human Monocytes
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