scholarly journals Effects of Black Cumin Seed Oil on Oxidative Stress and Expression of Membrane-Cytoskeleton Linker Proteins, Radixin and Moesin, in Streptozotocin Induced Diabetic Liver

2021 ◽  
Author(s):  
Ugur Seker
Keyword(s):  
Oxidative Stress ◽  
Seed Oil ◽  
Black Cumin ◽  
Membrane Cytoskeleton ◽  
Black Cumin Seed ◽  
Cumin Seed ◽  
Black Cumin Seed Oil

scholarly journals A case study on in vitro investigations of the potent biological activities of wheat germ and black cumin seed oil

2015 ◽  
Vol 39 ◽  
pp. 801-812 ◽  
Author(s):  
Didem AĞ ŞELECİ ◽  
Zinar Pınar GÜMÜŞ ◽  
Murat YAVUZ ◽  
Muharrem ŞELECİ ◽  
Rebecca BONGARTZ ◽  
...  
Keyword(s):  
Wheat Germ ◽  
Seed Oil ◽  
Biological Activities ◽  
Black Cumin ◽  
Black Cumin Seed ◽  
Cumin Seed ◽  
Black Cumin Seed Oil

scholarly journals Black cumin seed oil increase leucocyte and CD4Thelper number in sprague-dawley rats induced with dimethylbenzanthracene

2019 ◽  
Vol 8 (2) ◽  
pp. 238
Author(s):  
Titiek Hidayati ◽  
Akrom Akrom ◽  
Indrayanti Indrayanti ◽  
Sagiran Sagiran
Keyword(s):  
Cell Count ◽  
Seed Oil ◽  
Corn Oil ◽  
Sprague Dawley ◽  
Black Cumin ◽  
Th Cell ◽  
Group I ◽  
Black Cumin Seed ◽  
Cumin Seed ◽  
Black Cumin Seed Oil

<p>Cigarette smoke contains 7, 12 dimethylbenzanthracene (DMBA). Metabolic of DMBA is immunosuppressive. Black cumin seed oil (BCSO) is an immunomodulation. The aim of this study was to determine the effect of BCSO on leukocyte, CD4Th and CD4CD25Treg in Sprague-Dawley (SD) mice induced with DMBA. The 96 SD rats were divided into 8 groups of 12. Group I received aquabidest and standard feeding. Groups II, III and IV received BCSO (an equivalent of 6.8, 68 and 136 mg/kg BW / day thymoquinone, respectively). Group V received thymoquinone (50 mg / kg BW / day) and group VI received tamoxifen (60 mg / kg BW). Group VII (DMBA) was induced with DMBA (10x20mg / kg BW for 5 weeks). Group VIII received standard feeding and corn oil treatment. In the third week, all groups began to be induced with DMBA (20 mg/kg BW twice per week for five weeks). Data collection of leukocytes, CD4Th and CD4CD25Treg was performed at week 27th. The mean difference of CD4Th and CD4CD25Treg counts between groups was calculated with one way ANOVA. Results: The administration of BCSO, thymoquinone, and tamoxifen had increased leukocytes and CD4 Th cell count. The CD4Th cell count of the treatment groups was higher than that of the DMBA group (p &lt;0.05). BCSO equivalent doses of 6.8 and 68 mg/kg BW / day thymoquinone showed immunoprotective effects. Conclusion: It can be concluded that the BCSO administration at doses of 6.8 and 68 mg/kg BW / day shows immunoprotective effects due to DMBA induction.</p>

scholarly journals The effect of physical activity on lymphocyte count in smokers who consume black cumin seed (Nigella sativa L.) oil

2020 ◽  
Vol 9 (1) ◽  
pp. 8
Author(s):  
Titiek Hidayati ◽  
Akrom Akrom ◽  
Laili Apriani
Keyword(s):  
Physical Activity ◽  
Seed Oil ◽  
T Test ◽  
P Value ◽  
Anova Test ◽  
Black Cumin ◽  
Black Cumin Seed ◽  
One Way Anova ◽  
Cumin Seed ◽  
Black Cumin Seed Oil

Twenty percent of the total number of human leukocytes is lymphocytes. Lymphocytes are responsible for the control of the adaptive immune system. Physical activity is any body movement that requires energy to do it. Physical activity is related to changes in a person's immunity so that it can reduce the risks of diseases such as obesity, hypertension, diabetes, cancer, and stroke. Black Cumin Seed Oil (BCSO) in various studies has been widely used as a supplement, especially as an immune-modulator. The purpose of this study is to see the effect of physical activity on lymphocyte levels in smokers who have been given Black Cumin Seed Oil for 30 days. This study used a single-blind Randomized Controlled Trial (RCT) method, with a total of 36 test subjects divided into four groups. Group 1 received placebo 3x1 capsules/day, group 2 received BCSO 3x1 capsules/day, group 3 received BCSO 3x2 capsules/day, and group 4 received BCSO 3x3 capsules/day. The intervention was carried out for 30 days, then on the 31st-day blood was drawn for analysis. Data analysis using an independent t-test to see the average group with high and low activity, while to see the average lymphocyte between treatment groups using one way ANOVA test. The test results were said to be significant if p &lt;0.05. The p-value of the independent t-test is 0.045, and one way ANOVA test p-value is 0.343. In conclusion, physical activity can increase lymphocyte levels significantly, but not on BCSO administration.

scholarly journals Formulasi dan Uji Aktivitas Antibakteri Sediaan Emulgel Minyak Biji Jintan Hitam (Nigella sativa L.) terhadap Bakteri Staphylococcus epidermidis

2021 ◽  
Vol 11 (2) ◽  
pp. 121-131
Author(s):  
Nesa Agistia ◽  
Melzi Oktaviani ◽  
Wildan Khairi Mukhtadi ◽  
Della Ariska
Keyword(s):  
Antibacterial Activity ◽  
Staphylococcus Epidermidis ◽  
Seed Oil ◽  
Nigella Sativa ◽  
Positive Control ◽  
Diffusion Method ◽  
Black Cumin ◽  
Black Cumin Seed ◽  
Cumin Seed ◽  
Black Cumin Seed Oil

Acne is a skin problem that often occurs, one of the causes is the bacterium Staphylococcus epidermidis. Black cumin seed oil (Nigella sativa L.) can be used as an antibacterial because it contains thymoquinone and α-pinene. This study aims to obtain black cumin seed oil emulgel preparations that has antibacterial activity against Staphylococcus epidermidis. The preparations were formulated with concentrations of 3% (FI), 5% (FII), and 7% (FIII). Evaluation of the preparation was carried out for eight weeks including organoleptic tests, spreadability, emulsion type, pH, viscosity, homogeneity. Antibacterial activity tests was carried out using the well-diffusion method. The results of the evaluation of all three formulas obtained showed a semi-solid consistency, light brown in color, characteristically smelled of black cumin seed oil, stable, M/A emulsion type, homogeneous, non-irritating, pH FI = 4.51-4.95, FII = 4.72-4.99, FIII = 4.57-4.87, dispersion FI = 3.2-3.8 cm, FII = 3.3-3.9 cm, FIII = 3.4-3.9 cm, viscosity FI = 10.7-26.1 Ns/m2, FII = 11.2-32.0 Ns/m2, FIII = 11.5-34.1 Ns/m2. The antibacterial activity test showed the inhibitory power of FI 11,66±0,09 mm, FII 14.48±0.03 mm, FIII 17.35±0,.8 mm, lower than the positive control (clindamycin). All three black cumin seed oil emulgel preparations obtained met the physical requirements and had bacterial inhibition (p

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