The Effect of 25-OH Vitamin D on IL-12 and Biochemical Parameters in Patients with Metabolic Syndrome

Introduction: Metabolic syndrome includes a range of disorders that increase the risk of cardiovascular disease and diabetes mellitus. In this study, we examined the serum level of vitamin D3 in diabetic individuals with metabolic syndrome compared with non-diabetic individuals without metabolic syndrome and the association of serum vitamin D3 levels with metabolic syndrome and atherogenic factor (LDL/HDL). Material and Methods: In a case-control study, we included 110 women with metabolic syndrome according to ATP III criteria and 127 healthy women as a control group. Serum concentration of total cholesterol, LDL-C, FBS, HDL-C and serum triglyceride determined by enzymatic method and colorimetric and, serum level 25-(OH) vitamin D determined by ELISA. Results: It was found that the two healthy and metabolic groups were significantly different in terms of total cholesterol levels, LDL and triglyceride levels, HDL, VLDL, FBS, atherogenic index (LDL/HDL) and vitamin D levels (p<0.05). All participants in the control group and the patient and the whole study population were divided into two categories of insufficient and sufficient based on their measured serum concentrations of 25-(OH) vitamin D. There was a significant difference between the group with insufficient levels of vitamin D in comparison with the group with sufficient levels of vitamin D in terms of total cholesterol, LDL and triglyceride levels, HDL, VLDL, FBS and atherogenic index (LDL/HDL) (p=0.000). Conclusion: The present results showed that there is a significant relationship between level 25-(OH) D and atherogenic index (LDL/HDL) and the incidence of metabolic syndrome.

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PREVALENCE OF 25-HYDROXY VITAMIN D DEFICIENCY AND SOME BIOCHEMICAL PARAMETERS IN IRAQI PATIENTS WITH RHEUMATOID ARTHRITIS AND THEIR ASSOCIATIONS WITH DISEASE ACTIVITY

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i4.36759 ◽

2020 ◽

pp. 132-136

Author(s):

ABDULNASSER M AL-GEBORI ◽

MOHAMMED HADI MUNSHED ALOSAMI ◽

NAWAL HAIDER AL-HASHIMI

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Disease Activity ◽

Biochemical Parameters ◽

Enzyme Linked Immunosorbent Assay ◽

Healthy Controls ◽

25 Hydroxy Vitamin D ◽

Calcium Magnesium ◽

Calcium And Magnesium ◽

25 Oh Vitamin D

Objectives: The objectives of the study were to evaluate changes in 25(OH) Vitamin D levels and some biochemical parameters in rheumatoid arthritis (RA) patients compared with healthy controls and assess the correlation of 25-hydroxy Vitamin D, calcium, magnesium, and disease activity. Study the effects of anti-RA drugs on these biochemical parameters and also the role of supplements calcium and 25-OH Vitamin D in RA patients. Methods: This study conducted between 60 patients for RA and 20 healthy controls according to the American College of Rheumatology standards in 2010. In this study, 25-hydroxy Vitamin D was measured using an enzyme-linked immunosorbent assay, and also some biochemical parameters were measured with a spectrophotometer (Humalyzer 2000). Results: Serum 25(OH) Vitamin D, calcium, magnesium, and albumin levels were significantly lower in RA patients compared with healthy controls. Serum alanine aminotransferase aspartate aminotransferase levels were significantly increased in RA patients compared with healthy controls. The correlation was non-significantly among 25-hydroxy Vitamin D and clinical disease activity index (CDAI), while the results showed significantly inverse correlation calcium and magnesium concentrations with CDAI. Conclusion: 25-OH Vitamin D, calcium, albumin, and magnesium deficiency appear to be widespread in patients with RA. Thus, biochemical changes in RA are reflected in the pathogenesis of RA. Furthermore, in these results, there is no relationship between Vitamin D and the disease activity, while there is a relationship between calcium and magnesium with disease activity.

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The vitamin D receptor geneBsmI polymorphism is not associated with anthropometric and biochemical parameters describing metabolic syndrome in postmenopausal women

Gynecological Endocrinology ◽

10.1080/09513590802302985 ◽

2008 ◽

Vol 24 (9) ◽

pp. 514-518 ◽

Cited By ~ 25

Author(s):

Urszula Tworowska-Bardzińska ◽

Felicja Lwow ◽

Eliza Kubicka ◽

Łukasz Łaczmański ◽

Diana Jędzrzejuk ◽

...

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Postmenopausal Women ◽

Vitamin D Receptor ◽

Biochemical Parameters

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Assessment of Relationship Between Serum Vitamin D Levels and Metabolic Syndrome Components in Hemodialysis Patients

Galician Medical Journal ◽

10.21802/gmj.2021.1.3 ◽

2021 ◽

Vol 28 (1) ◽

pp. E202113

Author(s):

Sevil Karahan Yılmaz ◽

Cuma Mertoğlu ◽

Aylin Ayaz

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Vitamin D Insufficiency ◽

Hemodialysis Patients ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

25 Oh Vitamin D

Aim: This study is aimed to evaluate the relationship between serum vitamin D levels and metabolic syndrome in hemodialysis patients. Materials and Methods: This study was conducted with participation of 80 patients undergoing hemodialysis for more than 6 months three times a week, aged > 18 years. Their height, dry weight, waist circumference were measured. Biochemical parameters such as serum 25-hydroxyvitamin D, lipid profile, and fasting blood glucose were analyzed. Metabolic syndrome was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Severe vitamin D deficiency, 25 (OH) vitamin D < 5 ng/ml; mild vitamin D deficiency, 25 (OH) vitamin D 5-15 ng/ml; vitamin D insufficiency, 25 (OH) vitamin D 16-30 ng/ml, and vitamin D sufficiency, 25 (OH) vitamin D > 30 ng/ml were categorized. Statistical analysis of the data was performed with the use of SPSS version 21.0. Results: 48.4% of hemodialysis patients were identified to have metabolic syndrome. According to the serum levels of vitamin D; 35.0% of patients had severe vitamin D deficiency, 37.4% of patients had mild vitamin D deficiency, 18.8% of patients had vitamin D insufficiency and 8.8% of patients had vitamin D sufficiency (> 30 ng/ml). Vitamin D insufficiency was significantly associated with metabolic syndrome and central obesity. Conclusions: Deficiency/insufficiency is observed in serum 25-hydroxyvitamin D levels in hemodialysis patients. Vitamin D insufficiency is associated with metabolic syndrome.

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The Effect Of 25-OH Vitamin D On Biochemical And IL-12 Parameters In Patients With Metabolic Syndrome

Haydarpasa Numune Training and Research Hospital Medical Journal ◽

10.14744/hnhj.2021.10846 ◽

2021 ◽

Author(s):

Gülbu Işıtmangil

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

25 Oh Vitamin D

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A Comparative assessment of Metabolic Syndrome and its association with Vitamin D and other risk factors in Type 2 Diabetes Mellitus Patients

Current Diabetes Reviews ◽

10.2174/1573399816666200716193115 ◽

2020 ◽

Vol 16 ◽

Author(s):

Ammar Abdulrahman Jairoun ◽

Moyad Jamal Shahwan ◽

Mohammed Husham Khattab

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Metabolic Syndrome ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Diagnostic Criteria ◽

Biochemical Parameters ◽

World Health ◽

Diabetic Patients

Objectives: To determine the overall prevalence of metabolic syndrome using World health organization (WHO); National Cholesterol Education program (NCEP) and International diabetes federation (IDF) guidelines and to study its association with vitamin D and other biochemical parameters in patients with type 2 Diabetes mellitus, as well as to identify the set of biochemical parameters that jointly influence the metabolic syndrome using different diagnostic criteria. Methods: A cross-sectional study was carried out at private health care center. A total of 291 diabetic patients. Sociodemographic, clinical, and laboratory data were obtained from the medical records of patients. Statistical analysis was carried out using the Statistical Package for the Social Sciences (SPSS, version 23). Results: A total number of 291 patients with T2DM were included in this study. The overall prevalence of metabolic syndrome among the study subjects was 48.1%, 87.3%, 64.9% using WHO, IDF and NCEP-ATPIII criteria respectively. The highest prevalence was reported following IDF diagnostic criteria. Sex, triglyceride and fasting blood sugar were associated factors of metabolic syndrome by all the three diagnostic criteria of metabolic syndrome. Conclusion: the study revealed high prevalence rate of metabolic syndrome among type 2 diabetic patients, which was highest 87.3% according to IDF and lowest was observed in WHO criteria 48.1%. A significant variance in the prevalence of metabolic syndrome was reported between WHO, IDF and NCEP criteria.

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