Cellular Homeostasis or Tumorigenesis: USP7 Playing the Double Agent

2018 ◽  
Vol 4 ◽  
Keyword(s):  
Cellular Homeostasis ◽  
Double Agent

Mitochondrial hyperfusion: a friend or a foe

2020 ◽  
Vol 48 (2) ◽  
pp. 631-644 ◽  
Author(s):  
Rajdeep Das ◽  
Oishee Chakrabarti
Keyword(s):  
Negative Impact ◽  
Cellular Stress ◽  
Cellular Homeostasis ◽  
Mitochondrial Population

The cellular mitochondrial population undergoes repeated cycles of fission and fusion to maintain its integrity, as well as overall cellular homeostasis. While equilibrium usually exists between the fission–fusion dynamics, their rates are influenced by organellar and cellular metabolic and pathogenic conditions. Under conditions of cellular stress, there is a disruption of this fission and fusion balance and mitochondria undergo either increased fusion, forming a hyperfused meshwork or excessive fission to counteract stress and remove damaged mitochondria via mitophagy. While some previous reports suggest that hyperfusion is initiated to ameliorate cellular stress, recent studies show its negative impact on cellular health in disease conditions. The exact mechanism of mitochondrial hyperfusion and its role in maintaining cellular health and homeostasis, however, remain unclear. In this review, we aim to highlight the different aspects of mitochondrial hyperfusion in either promoting or mitigating stress and also its role in immunity and diseases.

Downregulation of Hemeoxygenase-1 and Altered Cellular Homeostasis in Cystic Fibrosis

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
SP Chillappagari ◽  
S Venkatesan ◽  
V Garapati ◽  
P Mahavadi ◽  
A Munder ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Cellular Homeostasis

Biological Activity of Trans-Membrane Anion Carriers

2018 ◽  
Vol 25 (30) ◽  
pp. 3560-3576 ◽  
Author(s):  
Massimo Tosolini ◽  
Paolo Pengo ◽  
Paolo Tecilla
Keyword(s):  
Biological Activity ◽  
Membrane Transport ◽  
Anticancer Agents ◽  
Biological Effects ◽  
Structure Activity Relationship ◽  
New Drugs ◽  
Activity Relationship ◽  
Anion Channels ◽  
Cellular Homeostasis ◽  
Structure Activity

Natural and synthetic anionophores promote the trans-membrane transport of anions such as chloride and bicarbonate. This process may alter cellular homeostasis with possible effects on internal ions concentration and pH levels triggering several and diverse biological effects. In this article, an overview of the recent results on the study of aniontransporters, mainly acting with a carrier-type mechanism, is given with emphasis on the structure/activity relationship and on their biological activity as antibiotic and anticancer agents and in the development of new drugs for treating conditions derived from dysregulation of natural anion channels.

scholarly journals Age Also Matters for Gerontologists: Personal and Professional Perspectives on Growing Older

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 670-671
Author(s):  
Phillip Clark ◽  
Margaret Perkinson
Keyword(s):  
Lived Experience ◽  
Psychosocial Development ◽  
Scientific Inquiry ◽  
Personal Experience ◽  
The Third ◽  
Research Paradigms ◽  
Quantitative And Qualitative Research ◽  
Professional Perspectives ◽  
Double Agent ◽  
The Life Course

Abstract Gerontology is a unique field of scientific inquiry, because it embodies both professional and personal dimensions of experience and poses questions for its researchers. How does our work help us understand our own personal experience of aging? How does the reality of growing older change our teaching and research? As gerontologists, we embody two narratives of the aging experience, one academic and professional (with its dependence on theory and scientific research), the other intimately personal (with its own lived experience and practical insight acquired over the life course). How this dynamic unfolds is as personal as each of us as individuals, and embodies our own disciplinary backgrounds; yet collectively it has implications for how we approach an understanding of what it means to grow old. This symposium explores different facets of this dynamic from four perspectives of different individuals and differing disciplines. The first paper assesses the limitations of both quantitative and qualitative research paradigms in revealing the deeply idiosyncratic nature of personal aging. The second develops the metaphor of “double agent of aging” to characterize the two narratives of professional and personal aging. The third uses Erikson’s theory of psychosocial development to weave together the professional, practical, and personal dimensions of gerontology. Finally, the last develops the metaphor of arcs and stages in conceptualizing a gerontological career. The symposium concludes with recommendations for the integration of theoretical, practical, and personal insights into teaching, research, and service in a way that embraces, enhances, and extends the field of gerontology.

scholarly journals CISD2 maintains cellular homeostasis

2021 ◽  
pp. 118954
Author(s):  
Zhao-Qing Shen ◽  
Yi-Long Huang ◽  
Yuan-Chi Teng ◽  
Tai-Wen Wang ◽  
Cheng-Heng Kao ◽  
...  
Keyword(s):  
Cellular Homeostasis

scholarly journals The non‐specific lethal (NSL) complex at the crossroads of transcriptional control and cellular homeostasis

EMBO Reports ◽  
2019 ◽  
Vol 20 (7) ◽  
Author(s):  
Bilal N Sheikh ◽  
Sukanya Guhathakurta ◽  
Asifa Akhtar
Keyword(s):  
Transcriptional Control ◽  
Cellular Homeostasis

scholarly journals NOD-Like Receptors: Guards of Cellular Homeostasis Perturbation during Infection

2021 ◽  
Vol 22 (13) ◽  
pp. 6714
Author(s):  
Gang Pei ◽  
Anca Dorhoi
Keyword(s):  
Immune System ◽  
Innate Immune System ◽  
Current Knowledge ◽  
Protein Translation ◽  
Innate Immune ◽  
Cellular Homeostasis ◽  
Translation Block ◽  
Cytoskeleton Disruption ◽  
Molecular Patterns ◽  
Fine Tune

The innate immune system relies on families of pattern recognition receptors (PRRs) that detect distinct conserved molecular motifs from microbes to initiate antimicrobial responses. Activation of PRRs triggers a series of signaling cascades, leading to the release of pro-inflammatory cytokines, chemokines and antimicrobials, thereby contributing to the early host defense against microbes and regulating adaptive immunity. Additionally, PRRs can detect perturbation of cellular homeostasis caused by pathogens and fine-tune the immune responses. Among PRRs, nucleotide binding oligomerization domain (NOD)-like receptors (NLRs) have attracted particular interest in the context of cellular stress-induced inflammation during infection. Recently, mechanistic insights into the monitoring of cellular homeostasis perturbation by NLRs have been provided. We summarize the current knowledge about the disruption of cellular homeostasis by pathogens and focus on NLRs as innate immune sensors for its detection. We highlight the mechanisms employed by various pathogens to elicit cytoskeleton disruption, organelle stress as well as protein translation block, point out exemplary NLRs that guard cellular homeostasis during infection and introduce the concept of stress-associated molecular patterns (SAMPs). We postulate that integration of information about microbial patterns, danger signals, and SAMPs enables the innate immune system with adequate plasticity and precision in elaborating responses to microbes of variable virulence.

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