scholarly journals Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury

2018 ◽  
Vol 4 ◽  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Hepatic Inflammation ◽  
Cholestatic Liver Injury

scholarly journals Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice

2017 ◽  
Vol 161 (1) ◽  
pp. 34-47 ◽  
Author(s):  
Jibiao Li ◽  
Benjamin L Woolbright ◽  
Wen Zhao ◽  
Yifeng Wang ◽  
David Matye ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Duct ◽  
Liver Injury ◽  
Loss Of Function ◽  
Hepatic Bile ◽  
Acid Accumulation ◽  
Cholestatic Liver Injury

Su1599 VANCOMYCIN PRETREATMENT AGGRAVATES ACUTE CHOLESTATIC LIVER INJURY AND FIBROSIS BY DISRUPTING THE MICROBIOTA FUNCTION AND BILE ACID HOMESTASIS

2020 ◽  
Vol 158 (6) ◽  
pp. S-1352
Author(s):  
Haiyue He ◽  
Yanliang Hou ◽  
Zichun Li ◽  
Xiaomei Zhang ◽  
Xiaowei Liu
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Cholestatic Liver Injury

Role of nuclear bile acid receptor, FXR, in determining ATP-binding casette (ABC) transporter expression and cholestatic liver injury in common bile duct-ligated mice

2003 ◽  
Vol 124 (4) ◽  
pp. A697-A698
Author(s):  
Martin Wagner ◽  
Peter Fickert ◽  
Gemot Zollner ◽  
Andrea Fuchsbichler ◽  
Dagmar Silbert ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Duct ◽  
Liver Injury ◽  
Common Bile Duct ◽  
Abc Transporter ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
Cholestatic Liver Injury ◽  
Transporter Expression

scholarly journals Obeticholic Acid Protects Against Cholestatic Liver Injury Induced by Lithocholic Acid via Inhibiting Exogenous Cell Apoptosis

2021 ◽  
Author(s):  
Yangping Zhu ◽  
Changling Wang ◽  
Jingyi Yu ◽  
Yingying Miao ◽  
Yuanyuan Chai ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Lithocholic Acid ◽  
Farnesoid X Receptor ◽  
Multi Drug Resistance ◽  
Caspase 8 ◽  
Obeticholic Acid ◽  
Cholestatic Liver Injury

Abstract Background: Lithocholic acid (LCA) is one kind of endogenous bile acids which is a typical index in primary biliary cholangitis (PBC). It could cause severe cholestatic liver injury in rodents. Obeticholic acid (OCA) is a major treatment for PBC. However, its effect and mechanism in LCA-induced liver injury was still unclear beside of bile acid regulation. This study aims to evaluate the hepatoprotective effect and mechanism of OCA against LCA-induced cholestatic liver injury. Results: LCA-induced upregulations of ALT, AST, ALP and TBA were reduced and the bile acid profiles in serum, liver and bile were improved significantly by OCA. This bile acid regulating effect of OCA was mainly based on increasing the expression of bile acid efflux transporters bile salt export pump (BSEP), multidrug resistant associated protein 2 (MRP2), MRP3 and multi-drug resistance 3 (MDR3) instead of bile acid synthesis inhibition. Furthermore, it was found that OCA reduced the activation and expression of Caspase 8/3 signaling pathway without the change of p-MLKL and BAX in LCA-induced cholestatic model. And the inhibition of Caspase 8/3 signaling pathway depended on the activation of Farnesoid X receptor (FXR) to inhibit Caspase 8 cleavage to form a active complex.Conclusions: This study found OCA improved LCA-induced cholestatic liver injury via FXR-induced exogenous cell apoptosis, which provided a new evidence for the application of OCA to ameliorate PBC in clinical.

Loss of BSEP/ABCB11 protects MDR2/ABCB4 KO mice from cholestatic liver injury by altering bile acid profile and signaling

2018 ◽  
Author(s):  
CD Fuchs ◽  
G Paumgartner ◽  
S Wolfrum ◽  
A Wahlström ◽  
M Stahlman ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Cholestatic Liver Injury

Protective effect of herbal medicine Huangqi decoction against chronic cholestatic liver injury by inhibiting bile acid-stimulated inflammation in DDC-induced mice

Phytomedicine ◽  
2019 ◽  
Vol 62 ◽  
pp. 152948 ◽  
Author(s):  
Wen-Kai Li ◽  
Guo-Feng Wang ◽  
Tian-Ming Wang ◽  
Yuan-Yuan Li ◽  
Yi-Fei Li ◽  
...  
Keyword(s):  
Bile Acid ◽  
Herbal Medicine ◽  
Liver Injury ◽  
Protective Effect ◽  
Cholestatic Liver Injury

Biliary intervention aggravates cholestatic liver injury, and induces hepatic inflammation, proliferation and fibrogenesis in BDL mice

2011 ◽  
Vol 63 (3) ◽  
pp. 277-284 ◽  
Author(s):  
Yang-An Wen ◽  
Ding Liu ◽  
Qian-Yun Zhou ◽  
Shi-Feng Huang ◽  
Peng Luo ◽  
...  
Keyword(s):  
Liver Injury ◽  
Hepatic Inflammation ◽  
Cholestatic Liver Injury

Limb expression 1-like (LIX1L) protein promotes cholestatic liver injury by regulating bile acid metabolism

2021 ◽  
Author(s):  
Jie Li ◽  
Xiaoyun Zhu ◽  
Meihui Zhang ◽  
Yanqiu Zhang ◽  
Shengtao Ye ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Cholestatic Liver Injury
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