scholarly journals Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice

2017 ◽  
Vol 161 (1) ◽  
pp. 34-47 ◽  
Author(s):  
Jibiao Li ◽  
Benjamin L Woolbright ◽  
Wen Zhao ◽  
Yifeng Wang ◽  
David Matye ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Duct ◽  
Liver Injury ◽  
Loss Of Function ◽  
Hepatic Bile ◽  
Acid Accumulation ◽  
Cholestatic Liver Injury

Role of nuclear bile acid receptor, FXR, in determining ATP-binding casette (ABC) transporter expression and cholestatic liver injury in common bile duct-ligated mice

2003 ◽  
Vol 124 (4) ◽  
pp. A697-A698
Author(s):  
Martin Wagner ◽  
Peter Fickert ◽  
Gemot Zollner ◽  
Andrea Fuchsbichler ◽  
Dagmar Silbert ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Duct ◽  
Liver Injury ◽  
Common Bile Duct ◽  
Abc Transporter ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
Cholestatic Liver Injury ◽  
Transporter Expression

Bid-mediated apoptosis does not contribute to cholestatic liver injury following bile duct ligation

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
P Nalapareddy ◽  
S Schüngel ◽  
MP Manns ◽  
H Jaeschke ◽  
A Vogel
Keyword(s):  
Bile Duct ◽  
Liver Injury ◽  
Bile Duct Ligation ◽  
Duct Ligation ◽  
Cholestatic Liver Injury

scholarly journals Cell-specific regulatory effects of CXCR2 on cholestatic liver injury

2019 ◽  
Vol 317 (6) ◽  
pp. G773-G783 ◽  
Author(s):  
Takanori Konishi ◽  
Rebecca M. Schuster ◽  
Holly S. Goetzman ◽  
Charles C. Caldwell ◽  
Alex B. Lentsch
Keyword(s):  
Bile Duct ◽  
Liver Injury ◽  
Liver Damage ◽  
Chemokine Receptor ◽  
Therapeutic Target ◽  
Bile Duct Ligation ◽  
Wild Type ◽  
Neutrophil Accumulation ◽  
Duct Ligation ◽  
Cholestatic Liver Injury

The CXC chemokine receptor 2 (CXCR2) is critical for neutrophil recruitment and hepatocellular viability but has not been studied in the context of cholestatic liver injury following bile duct ligation (BDL). The present study sought to elucidate the cell-specific roles of CXCR2 on acute liver injury after BDL. Wild-type and CXCR2−/− mice were subjected BDL. CXCR2 chimeric mice were created to assess the cell-specific role of CXCR2 on liver injury after BDL. SB225002, a selective CXCR2 antagonist, was administrated intraperitoneally after BDL to investigate the potential of pharmacological inhibition. CXCR2−/− mice had significantly less liver injury than wild-type mice at 3 and 14 days after BDL. There was no difference in biliary fibrosis among groups. The chemokines CXCL1 and CXCL2 were induced around areas of necrosis and biliary structures, respectively, both areas where neutrophils accumulated after BDL. CXCR2−/− mice showed significantly less neutrophil accumulation in those injured areas. CXCR2Liver+/Myeloid+ and CXCR2Liver−/Myeloid− mice recapitulated the wild-type and CXCR2-knockout phenotypes, respectively. CXCR2Liver+/Myeloid+ mice suffered higher liver injury than CXCR2Liver+/Myeloid− and CXCR2Liver−/Myeloid+; however, only those chimeras with knockout of myeloid CXCR2 (CXCR2Liver+/Myeloid− and CXCR2Liver−/Myeloid−) showed reduction of neutrophil accumulation around areas of necrosis. Daily administration of SB225002 starting after 3 days of BDL reduced established liver injury at 6 days. In conclusion, neutrophil CXCR2 guides the cell to the site of injury, while CXCR2 on liver cells affects liver damage independent of neutrophil accumulation. CXCR2 appears to be a viable therapeutic target for cholestatic liver injury. NEW & NOTEWORTHY This study is the first to reveal cell-specific roles of the chemokine receptor CXCR2 in cholestatic liver injury caused by bile duct ligation. CXCR2 on neutrophils facilitates neutrophil recruitment to the liver, while CXCR2 on liver cells contributes to liver damage independent of neutrophils. CXCR2 may represent a viable therapeutic target for cholestatic liver injury.

scholarly journals A novel murine model of reversible bile duct obstruction demonstrates rapid improvement of cholestatic liver injury

2020 ◽  
Vol 8 (10) ◽  
Author(s):  
Sarah A. Taylor ◽  
Xin‐Yi Yeap ◽  
Jiao‐Jing Wang ◽  
Kyle D. Gromer ◽  
Alyssa Kriegermeier ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Injury ◽  
Murine Model ◽  
Bile Duct Obstruction ◽  
Rapid Improvement ◽  
Duct Obstruction ◽  
Cholestatic Liver Injury

scholarly journals C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice

Hepatology ◽  
2018 ◽  
Vol 67 (4) ◽  
pp. 1441-1457 ◽  
Author(s):  
Runping Liu ◽  
Xiaojiaoyang Li ◽  
Zhiming Huang ◽  
Derrick Zhao ◽  
Bhagyalaxmi Sukka Ganesh ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Injury ◽  
Bile Duct Ligation ◽  
Intestinal Epithelial ◽  
Homologous Protein ◽  
Duct Ligation ◽  
Cholestatic Liver Injury

Su1247 FXR AGONIST TROPIFEXOR AMELIORATES CHOLESTATIC LIVER INJURY IN A NEONATAL PIGLET MODEL OF BILE DUCT LIGATION

2020 ◽  
Vol 158 (6) ◽  
pp. S-556-S-557
Author(s):  
YONGTAO XIAO ◽  
YANG LIU ◽  
XINBEI TIAN ◽  
WEI CAI
Keyword(s):  
Bile Duct ◽  
Liver Injury ◽  
Bile Duct Ligation ◽  
Neonatal Piglet ◽  
Duct Ligation ◽  
Cholestatic Liver Injury
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