Yinchenzhufu decoction protects against alpha-naphthylisothiocyanate-induced acute cholestatic liver injury in mice by ameliorating disordered bile acid homeostasis and inhibiting inflammatory responses

2020 ◽  
Vol 254 ◽  
pp. 112672 ◽  
Author(s):  
Guo-Feng Wang ◽  
Yuan-Yuan Li ◽  
Rong Shi ◽  
Tian-Ming Wang ◽  
Yi-Fei Li ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Inflammatory Responses ◽  
Cholestatic Liver Injury

scholarly journals Kinsenoside Alleviates 17α-Ethinylestradiol-Induced Cholestatic Liver Injury in Rats by Inhibiting Inflammatory Responses and Regulating FXR-Mediated Bile Acid Homeostasis

2021 ◽  
Vol 14 (5) ◽  
pp. 452
Author(s):  
Jiaxiong Ming ◽  
Qianqian Xu ◽  
Limin Gao ◽  
Yanfang Deng ◽  
Jie Yin ◽  
...  
Keyword(s):  
Body Weight ◽  
Bile Acid ◽  
Liver Injury ◽  
Inflammatory Responses ◽  
Metabolic Enzyme ◽  
Control Group ◽  
High Dose ◽  
Group Model ◽  
Biliary Cirrhosis ◽  
Cholestatic Liver Injury

Cholestasis is an important predisposing factor of liver diseases, such as hepatocyte necrosis, liver fibrosis and primary biliary cirrhosis. In this study, we aimed to investigate the effects of Kinsenoside (KD), a natural active ingredient of Anoectochilus roxburghii, on estrogen-induced cholestatic liver injury in Sprague-Dawley rats and the underlying mechanism. The rats were randomly divided into six groups: control group, model group, low-dose KD group (50 mg/kg body weight, KD-L), medium-dose KD group (100 mg/kg body weight, KD-M), high-dose KD group (200 mg/kg body weight, KD-H) and ursodeoxycholic acid group (40 mg/kg body weight, UDCA). 17α-Ethinylestradiol (EE) was used to establish an experimental animal model of estrogen-induced cholestasis (EIC). The results demonstrated that KD alleviated liver pathologic damage, serum biochemical status and inhibited hepatocellular microstructure disorder and bile duct hyperplasia in EE-induced cholestatic rats. Mechanically, KD alleviated EE-induced cholestatic liver injury by inhibiting inflammatory responses and regulating bile acid homeostasis. Concretely, KD reduced the expression of IL-1β and IL-6 by inhibiting NF-κB p65 to suppress EE-mediated inflammation in rat liver. KD enhanced the expression of FXR and inhibited EE-mediated reduction of FXR in vitro and in vivo. It was the potential mechanism that KD mitigates cholestasis by increasing efflux and inhibiting uptake of bile acids via FXR-mediated induction of bile salt export pump (BSEP) and reduction of Na+-dependent taurocholate cotransport peptide (NTCP) to maintain bile acid homeostasis. Moreover, KD repressed the bile acid synthesis through reducing the expression of synthetic enzyme (CYP7A1), thereby normalizing the expression of metabolic enzyme (SULT2A1) of bile acid. In conclusion, our results revealed that KD may be an effective drug candidate for the treatment of cholestasis.

scholarly journals Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice

2017 ◽  
Vol 161 (1) ◽  
pp. 34-47 ◽  
Author(s):  
Jibiao Li ◽  
Benjamin L Woolbright ◽  
Wen Zhao ◽  
Yifeng Wang ◽  
David Matye ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Duct ◽  
Liver Injury ◽  
Loss Of Function ◽  
Hepatic Bile ◽  
Acid Accumulation ◽  
Cholestatic Liver Injury

Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism

FEBS Journal ◽  
2020 ◽  
Vol 287 (15) ◽  
pp. 3328-3345
Author(s):  
Wen‐Jun Jia ◽  
Qiao‐Li Tang ◽  
Shan Jiang ◽  
Shi‐Quan Sun ◽  
Bin Xue ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Geranylgeranyl Diphosphate Synthase ◽  
Geranylgeranyl Diphosphate ◽  
Hepatic Bile ◽  
Cholestatic Liver Injury

Su1599 VANCOMYCIN PRETREATMENT AGGRAVATES ACUTE CHOLESTATIC LIVER INJURY AND FIBROSIS BY DISRUPTING THE MICROBIOTA FUNCTION AND BILE ACID HOMESTASIS

2020 ◽  
Vol 158 (6) ◽  
pp. S-1352
Author(s):  
Haiyue He ◽  
Yanliang Hou ◽  
Zichun Li ◽  
Xiaomei Zhang ◽  
Xiaowei Liu
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Cholestatic Liver Injury

Role of nuclear bile acid receptor, FXR, in determining ATP-binding casette (ABC) transporter expression and cholestatic liver injury in common bile duct-ligated mice

2003 ◽  
Vol 124 (4) ◽  
pp. A697-A698
Author(s):  
Martin Wagner ◽  
Peter Fickert ◽  
Gemot Zollner ◽  
Andrea Fuchsbichler ◽  
Dagmar Silbert ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Duct ◽  
Liver Injury ◽  
Common Bile Duct ◽  
Abc Transporter ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
Cholestatic Liver Injury ◽  
Transporter Expression

scholarly journals Obeticholic Acid Protects Against Cholestatic Liver Injury Induced by Lithocholic Acid via Inhibiting Exogenous Cell Apoptosis

2021 ◽  
Author(s):  
Yangping Zhu ◽  
Changling Wang ◽  
Jingyi Yu ◽  
Yingying Miao ◽  
Yuanyuan Chai ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Lithocholic Acid ◽  
Farnesoid X Receptor ◽  
Multi Drug Resistance ◽  
Caspase 8 ◽  
Obeticholic Acid ◽  
Cholestatic Liver Injury

Abstract Background: Lithocholic acid (LCA) is one kind of endogenous bile acids which is a typical index in primary biliary cholangitis (PBC). It could cause severe cholestatic liver injury in rodents. Obeticholic acid (OCA) is a major treatment for PBC. However, its effect and mechanism in LCA-induced liver injury was still unclear beside of bile acid regulation. This study aims to evaluate the hepatoprotective effect and mechanism of OCA against LCA-induced cholestatic liver injury. Results: LCA-induced upregulations of ALT, AST, ALP and TBA were reduced and the bile acid profiles in serum, liver and bile were improved significantly by OCA. This bile acid regulating effect of OCA was mainly based on increasing the expression of bile acid efflux transporters bile salt export pump (BSEP), multidrug resistant associated protein 2 (MRP2), MRP3 and multi-drug resistance 3 (MDR3) instead of bile acid synthesis inhibition. Furthermore, it was found that OCA reduced the activation and expression of Caspase 8/3 signaling pathway without the change of p-MLKL and BAX in LCA-induced cholestatic model. And the inhibition of Caspase 8/3 signaling pathway depended on the activation of Farnesoid X receptor (FXR) to inhibit Caspase 8 cleavage to form a active complex.Conclusions: This study found OCA improved LCA-induced cholestatic liver injury via FXR-induced exogenous cell apoptosis, which provided a new evidence for the application of OCA to ameliorate PBC in clinical.

Loss of BSEP/ABCB11 protects MDR2/ABCB4 KO mice from cholestatic liver injury by altering bile acid profile and signaling

2018 ◽  
Author(s):  
CD Fuchs ◽  
G Paumgartner ◽  
S Wolfrum ◽  
A Wahlström ◽  
M Stahlman ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Cholestatic Liver Injury

Protective effect of herbal medicine Huangqi decoction against chronic cholestatic liver injury by inhibiting bile acid-stimulated inflammation in DDC-induced mice

Phytomedicine ◽  
2019 ◽  
Vol 62 ◽  
pp. 152948 ◽  
Author(s):  
Wen-Kai Li ◽  
Guo-Feng Wang ◽  
Tian-Ming Wang ◽  
Yuan-Yuan Li ◽  
Yi-Fei Li ◽  
...  
Keyword(s):  
Bile Acid ◽  
Herbal Medicine ◽  
Liver Injury ◽  
Protective Effect ◽  
Cholestatic Liver Injury

Limb expression 1-like (LIX1L) protein promotes cholestatic liver injury by regulating bile acid metabolism

2021 ◽  
Author(s):  
Jie Li ◽  
Xiaoyun Zhu ◽  
Meihui Zhang ◽  
Yanqiu Zhang ◽  
Shengtao Ye ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Cholestatic Liver Injury

Loss of BSEP protects MDR2/ABCB4 KO mice from cholestatic liver injury by altering bile acid profile and signaling

2018 ◽  
Vol 68 ◽  
pp. S449-S450
Author(s):  
C. Fuchs ◽  
G. Paumgartner ◽  
V. Mlitz ◽  
S. Wolfrum ◽  
A. Wahlström ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Cholestatic Liver Injury
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