scholarly journals Regional lung deflation with increased airway volume underlies the functional response to bronchodilators in chronic obstructive pulmonary disease

2019 ◽  
Vol 7 (24) ◽  
Author(s):  
Naoya Tanabe ◽  
Susumu Sato ◽  
Shigeo Muro ◽  
Hiroshi Shima ◽  
Tsuyoshi Oguma ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Functional Response ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Regional Lung ◽  
Lung Deflation

scholarly journals Regional Lung Sound Asynchrony in Chronic Obstructive Pulmonary Disease Patients

Respiration ◽  
2016 ◽  
Vol 92 (4) ◽  
pp. 252-257 ◽  
Author(s):  
Masamichi Mineshita ◽  
Hirotaka Kida ◽  
Hiroshi Handa ◽  
Hiroki Nishine ◽  
Naoki Furuya ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Lung Sound ◽  
Obstructive Pulmonary Disease ◽  
Regional Lung

scholarly journals RECENT ASPECTS OF CARDIAC REMODELING IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2018 ◽  
Vol 14 (3) ◽  
pp. 379-386 ◽  
Author(s):  
V. V. Lee ◽  
N. Yu. Timofeeva ◽  
V. S. Zadionchenko ◽  
T. V. Adasheva ◽  
N. V. Vysotskaya
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cardiovascular Diseases ◽  
Pulmonary Disease ◽  
Cardiac Remodeling ◽  
Systolic Dysfunction ◽  
Independent Effect ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Pulmonary Hyperinflation ◽  
Lung Deflation

The paper aimed to present evidence of the effect of some pathophysiological features of chronic obstructive pulmonary disease (COPD) on cardiac remodeling in patients free of overt cardiovascular diseases, traditional cardiovascular risk factors and pulmonary hypertension. Contrary to traditional beliefs that cardiac abnormalities in COPD have been mainly associated with the right ventricle, several recent studies have shown an independent effect of pulmonary hyperinflation and emphysema on left ventricular (LV) diastolic filling and LV hypertrophy. Pulmonary hyperinflation and emphysema cause intrathoracic hypovolemia, low preload, small end-diastolic dimension and mechanical compression of LV chamber which could worsen end-diastolic stiffness. Interestingly, that the presence of LV hypertrophy in COPD patients is important but currently poorly understood area of investigation. Pulmonary hyperinflation, increased arterial stiffness and sympathetic activation may be associated with LV hypertrophy. Two-dimensional ultrasound speckle tracking studies have shown the presence of sub-clinical LV systolic dysfunction in patients even with moderate COPD and free of overt cardiovascular diseases. Sarcopenia related to the inflammatory-catabolic state in COPD and hypoxia could play an important role regarding LV systolic dysfunction. Recent data reported the effects of long-acting bronchodilators on reducing lung hyperinflation (inducing lung deflation). Further studies are required to evaluate the effects of pharmacological lung deflation therapy on cardiac volume and function.

scholarly journals Effects of Bronchodilators on Regional Lung Sound Distribution in Patients with Chronic Obstructive Pulmonary Disease

Respiration ◽  
2014 ◽  
Vol 87 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Masamichi Mineshita ◽  
Shin Matsuoka ◽  
Teruomi Miyazawa
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Lung Sound ◽  
Obstructive Pulmonary Disease ◽  
Regional Lung

Effect Of Lung Deflation On Cardiac Function In Patients With Chronic Obstructive Pulmonary Disease

2011 ◽  
Author(s):  
Carolyn E. Come ◽  
Miguel J. Divo ◽  
Raul San Jose Estepar ◽  
Frank C. Sciurba ◽  
Gerard J. Criner ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cardiac Function ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lung Deflation

Mapping of regional lung microstructural parameters using hyperpolarized 129 Xe dissolved‐phase MRI in healthy volunteers and patients with chronic obstructive pulmonary disease

2018 ◽  
Vol 81 (4) ◽  
pp. 2360-2373 ◽  
Author(s):  
Agilo L. Kern ◽  
Marcel Gutberlet ◽  
Andreas Voskrebenzev ◽  
Filip Klimeš ◽  
Alexander Rotärmel ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Healthy Volunteers ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Microstructural Parameters ◽  
Regional Lung ◽  
Dissolved Phase

scholarly journals Surveillance of chronic obstructive pulmonary disease in high-risk individuals by using regional lung cancer mass screening

2014 ◽  
pp. 647 ◽  
Author(s):  
Yasuo Sekine ◽  
Ryoko Yanagibori ◽  
Kiminori Suzuki ◽  
Sonomi Sugiyama ◽  
Haruko Yamaji ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Chronic Obstructive Pulmonary Disease ◽  
High Risk ◽  
Pulmonary Disease ◽  
Mass Screening ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Regional Lung

Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 29 (2) ◽  
pp. 864-872
Author(s):  
Fernanda Borowsky da Rosa ◽  
Adriane Schmidt Pasqualoto ◽  
Catriona M. Steele ◽  
Renata Mancopes
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Oral Cavity ◽  
Pulmonary Disease ◽  
Thermal Sensation ◽  
Sensory Function ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Age Related ◽  
Copd Patients

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Objective This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years ( SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years ( SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical evaluation of oral and oropharyngeal sensation by a speech-language pathologist. The sensory evaluation explored the detection of tactile and temperature stimuli delivered by cotton swab to six locations in the oral cavity and two in the oropharynx as well as identification of the taste of stimuli administered in 5-ml boluses to the mouth. Analyses explored the frequencies of accurate responses regarding stimulus location, temperature and taste between groups, and between age groups (“≤ 65 years” and “> 65 years”) within the COPD cohort. Results We found significantly higher frequencies of reported use of inhaled medications ( p < .001) and xerostomia ( p = .003) in the COPD cohort. Oral cavity thermal sensation ( p = .009) was reduced in the COPD participants, and a significant age-related decline in gustatory sensation was found in the COPD group ( p = .018). Conclusion This study found that most of the measures of oral and oropharyngeal sensation remained intact in the COPD group. Oral thermal sensation was impaired in individuals with COPD, and reduced gustatory sensation was observed in the older COPD participants. Possible links between these results and the use of inhaled medication by individuals with COPD are discussed.

The chronic obstructive pulmonary disease strategy

2002 ◽  
Vol 32 (3) ◽  
pp. 64-65 ◽  
Author(s):  
J. Burdon ◽  
R. Edwards
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease
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