THE EFFICACY OF FENBENDAZOLE* IN THE TREATMENT OF. NATURAL INFECTIONS OF FASCIOLA GIGANTICA AND FASCIOLA HEPATICA IN SHEEP

1981 ◽  
Vol 28 (1.4) ◽  
pp. 1
Author(s):  
GÜRALP Nevzat;TINAR
2006 ◽  
Vol 55 (4) ◽  
pp. 249-260 ◽  
Author(s):  
K. Ashrafi ◽  
M.A. Valero ◽  
M. Panova ◽  
M.V. Periago ◽  
J. Massoud ◽  
...  

1974 ◽  
Vol 11 (5) ◽  
pp. 407-416 ◽  
Author(s):  
A. H. Cheema

Gall bladders from 80 mature cattle infested with liver flukes were shrunken; their walls were thickened; and mucosa was raised into rugose folds, nodules and papillary projections. All contained thick bile and mature liver flukes, predominantly Fasciola gigantica and to a lesser extent Fasciola hepatica. There was an adenomatous proliferation of the lining epithelium as well as of submucosal glands forming numerous tubuloalveolar structures and cysts lined with a uniform layer of columnar epithelium. Fibrous stroma was more than normal, and there was a mild to heavy infiltration by inflammatory cells. Some bladders had many enterochromaffin cells in the epithelium lining the glandular structures. Mitotic figures were rare, and there was no evidence of malignancy. The condition is inflammatory and hyperplastic and is believed to be common in cattle infested with liver fluke. The clinical effects of this condition have not been studied.


2011 ◽  
Vol 178 (3-4) ◽  
pp. 264-272 ◽  
Author(s):  
Jill Pleasance ◽  
Herman W. Raadsma ◽  
S.E. Estuningsih ◽  
S. Widjajanti ◽  
Els Meeusen ◽  
...  

2021 ◽  
Vol 2 (2) ◽  
pp. 79-85
Author(s):  
Alisa Qudrotun Munawaroh ◽  
Endry Nugroho Prasetyo ◽  
Maharani Pertiwi Koentjoro

Fascioliasis is an infection of the trematodes of Fasciola hepatica and Fasciola gigantica which causes disease worldwide. This trematode infection commonly attacks ruminants, especially in cattle, buffalo, sheep, goats, pigs and humans, as well. This disease can cause significant economic losses in the livestock industry, mainly through death, liver damage, reduced production of meat, milk and wool, and expenses for deworming. Parasitological examination for identification of fasciola infection was carried out by visually observing fecal samples for adult worms and then examined by simple flotation (using saturated NaCl solution) and formalin-ethyl acetate sedimentation techniques. Here, we were systematically reviewed existing knowledge about sensitive and efficient fasciola observation methods for the identification of fasciola species. Four databases of articles that met the inclusion requirements were compiled for the literature review. This article was published between 2015-2020 and reports on the identification of fasciola species using one or a combination of sedimentation and flotation methods. As a result, the combined method of sedimentation and flotation has the best sensitivity and egg recovery rate (Ef) values for fasciola identification.   Abstrak Fascioliasis merupakan infeksi trematoda spesies Fasciola hepatica dan Fasciola gigantica yang menimbulkan penyakit di seluruh dunia. Infeksi trematoda ini umum menyerang ruminansia, terutama pada sapi, kerbau, domba, kambing, babi dan bisa terjadi pada manusia. Penyakit ini dapat menimbulkan kerugian ekonomi yang cukup besar dalam industri ternak, terutama melalui kematian, kerusakan hati, berkurangnya produksi daging, susu, dan wol, dan pengeluaran biaya untuk obat cacing. Pemeriksaan parasitologi untuk identifikasi infeksi fasciola dilakukan dengan mengamati sampel feses secara visual untuk cacing dewasa dan kemudian diperiksa dengan cara flotasi sederhana (menggunakan larutan NaCl jenuh) dan teknik sedimentasi formalin-etil asetat. Disini, kami meninjau secara sistematis pengetahuan yang ada tentang metode pengamatan fasciola yang sensitif dan efisien dalam identifikasi spesies fascioal. Empat data base artikel yang telah memenuhi syarat inklusi disusun untuk tinjauan literature review. Artikel ini terbit antara tahun 2015-2020 dan melaporkan identifikasi spesies fasciola menggunakan salah satu atau gabungan metode sedimentasi dan flotasi. Hasilnya, metode gabungan antara sedimentasi dan flotasi memiliki nilai sensitivitas dan nilai tingkat pemulihan telur (egg recovery rate, Ef) paling baik untuk identifikasi fasciola.


2021 ◽  
Vol 226 ◽  
pp. 00029
Author(s):  
Lili Zalizar ◽  
Khusnul Rahmawati ◽  
Abubakar Yaro

Fasciolosis is a disease caused by Fasciola gigantica (Cobbold, 1855) or Fasciola hepatica (Linnaeus, 1758) that infected ruminants and caused liver damaged and loss of productivity. To control Fasciola disease in cattle, it is necessary to consider differences in the prevalence or number of cases in various cattle breed. This research was conducted in two slaughterhouses in Batu and Pujon District, Malang Regency, East Java, Indonesia involving 50 livestock in each slaughterhouse, either beef or dairy cattle. Observation was done for 2 mo by performing liver necropsy, observing the presence of fibrosis and calcification of the bile duct, counting the number of worms and weighing the removed liver tissue. Result of this research the number of fasciolosis in Ongole and Limousin cattle (30.95 % and 35.94 %) was fewer compared to Simmental and Frisian Holstein (58.33 %). Average number of worms head–1 in each cattle breed; Limousin, Simmental, Ongole, and FH were (105, 49, 27 and 129) worms. Meanwhile, fibrosis score in each group were 1.48, 1.89, 1.33 and 1.75 respectively. It is suspected that differences in cattle breed had correlation with susceptibility towards infection. It is indicated that Limousin cattle are more tolerant against liver worm infection.


2021 ◽  
Author(s):  
Xier Luo ◽  
Kuiqing Cui ◽  
Zhiqiang Wang ◽  
Lijuan Yin ◽  
Zhipeng Li ◽  
...  

AbstractFasciola giganticaandFasciola hepaticaare causative pathogens offascioliasis, with the widest latitudinal, longitudinal, and altitudinal distribution; however, among parasites, they have the largest sequenced genomes, hindering genomic research. In the present study, we used various sequencing and assembly technologies to generate a new high-qualityFasciola giganticareference genome. We improved the integration of gene structure prediction, and identified two independent transposable element expansion events contributing to (1) the speciation between Fasciola and Fasciolopsis during the Cretaceous-Paleogene boundary mass extinction, and (2) the habitat switch to the liver during the Paleocene-Eocene Thermal Maximum, accompanied by gene length increment. Long interspersed element (LINE) duplication contributed to the second transposon-mediated alteration, showing an obvious trend of insertion into gene regions, regardless of strong purifying selection. Gene ontology analysis of genes with long LINE insertions identified membrane-associated and vesicle secretion process proteins, further implicating the functional alteration of the gene network. We identified 852 excretory/secretory proteins and 3300 protein-protein interactions betweenFasciola giganticaand its host. Among them, copper/zinc superoxide dismutase genes, with specific gene copy number variations, might play a central role in the phase I detoxification process. Analysis of 559 single-copy orthologs suggested thatFasciola giganticaandFasciola hepaticadiverged at 11.8 Ma near the Middle and Late Miocene Epoch boundary. We identified 98 rapidly evolving gene families, including actin and aquaporin, which might explain the large body size and the parasitic adaptive character resulting in these liver flukes becoming epidemic in tropical and subtropical regions.


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