Aims:
Investigation thyroid dysfunction and autoimmunity in pregnant women with gestational
diabetes mellitus.
Background:
This article was written to evaluate the thyroid function and anti-thyroid peroxidase (anti-
TPO) antibodies in pregnant women with gestational diabetes mellitus (GDM).
Method:
A total of 252 women with GDM and 252 healthy pregnant women were enrolled. Thyroid
tests, including TSH, FreeT3, Free T4, and anti-TPO were performed for all women at 24–28 weeks of
gestation. Data analysis was then carried out using SPSS ver. 22.
Result:
There was a significant difference between the experimental group (38.4%) and the control
group (14.06%) in terms of the prevalence of subclinical hypothyroidism (p= 0.016). The frequency of
anti-TPO was higher in the experimental group than the control group and positive anti-TPO was observed
in 18.6% of women with GDM and 10.3% of healthy pregnant women (P= 0.008).
Conclusion:
Thyroid disorders are observed in pregnant women with GDM more frequently than
healthy individuals and it may be thus reasonable to perform thyroid tests routinely.
Lower serum total bilirubin concentration is associated with higher prevalence of gestational diabetes mellitus in Japanese pregnant women
