On the mutation model used in the fingerprinting DNA

2020 ◽  
Vol 16 (4) ◽  
Author(s):  
Andrzej Krajka ◽  
Ireneusz Panasiuk ◽  
Adam Misiura ◽  
Grzegorz M. Wójcik

AbstractObjectivesThe most common technique of determining biological paternity or another relationship among people are the investigations of DNA polymorphism called Fingerprinting DNA. The key concept of these investigations is the statistical analysis, which leads to obtain the likelihood ratio (LR), sometimes called the paternity index.MethodsAmong the different assumptions stated in these computations is a mutation model (this model is used for all the computations).Results and conclusionsAlthough its influence on LR is usually negligible, there are some situations (when the mother–child mutation arises) when it is crucial.

1981 ◽  
Vol 13 (11) ◽  
pp. 1361-1369 ◽  
Author(s):  
R Crouchley

The Poisson process can be considered as an appropriate model for a collection of event streams such as residence histories or dwelling tenure series. However, the statistical analysis of Poisson models is complicated by the possible existence of heterogeneity and nonstationarity, and this paper notes the lack of tests which are available to investigate this. Likelihood ratio tests are developed and applied to some dwelling tenure series.


1993 ◽  
Vol 68 (6) ◽  
pp. 567-595 ◽  
Author(s):  
Fumio TAJIMA

2020 ◽  
Vol 15 (12) ◽  
pp. 1975-1988
Author(s):  
Luisa F. Sánchez-Peralta ◽  
Artzai Picón ◽  
Francisco M. Sánchez-Margallo ◽  
J. Blas Pagador

Abstract Purpose Data augmentation is a common technique to overcome the lack of large annotated databases, a usual situation when applying deep learning to medical imaging problems. Nevertheless, there is no consensus on which transformations to apply for a particular field. This work aims at identifying the effect of different transformations on polyp segmentation using deep learning. Methods A set of transformations and ranges have been selected, considering image-based (width and height shift, rotation, shear, zooming, horizontal and vertical flip and elastic deformation), pixel-based (changes in brightness and contrast) and application-based (specular lights and blurry frames) transformations. A model has been trained under the same conditions without data augmentation transformations (baseline) and for each of the transformation and ranges, using CVC-EndoSceneStill and Kvasir-SEG, independently. Statistical analysis is performed to compare the baseline performance against results of each range of each transformation on the same test set for each dataset. Results This basic method identifies the most adequate transformations for each dataset. For CVC-EndoSceneStill, changes in brightness and contrast significantly improve the model performance. On the contrary, Kvasir-SEG benefits to a greater extent from the image-based transformations, especially rotation and shear. Augmentation with synthetic specular lights also improves the performance. Conclusion Despite being infrequently used, pixel-based transformations show a great potential to improve polyp segmentation in CVC-EndoSceneStill. On the other hand, image-based transformations are more suitable for Kvasir-SEG. Problem-based transformations behave similarly in both datasets. Polyp area, brightness and contrast of the dataset have an influence on these differences.


2000 ◽  
Vol 23 (4) ◽  
pp. 725-727
Author(s):  
Lucía Cifuentes O. ◽  
Leonor Armanet B. ◽  
Raúl Aguirre A. ◽  
Juana Vargas B. ◽  
Mónica Acuña P.

DNA polymorphism is very useful in paternity analysis. The present paper describes paternity studies done using DNA profiles obtained with the (CAC)5 probe. All of the subjects studied were involved in nonjudicial cases of paternity. Genomic DNA digested with HaeIII was run on agarose gels and hybridized in the gel with the (CAC)5 probe labeled with 32P. The mean number of bands larger than the 4.3 kb per individual was 16.1. The mean proportion of bands shared among unrelated individuals was 0.08 and the mean number of test bands was 7.1. This corresponded to an exclusion probability greater than 0.999999. Paternity was excluded in 34.5% of the cases. The mutation frequency estimated from non-excluded cases was 0.01143 bands per child. In these cases, the paternity was confirmed by a locus-specific analysis of eight independent PCR-based loci. The paternity index was computed in all non-excluded cases. It can be concluded that this method is a powerful and inexpensive alternative to solve paternity doubts.


2017 ◽  
Vol 13 (3) ◽  
pp. 7275-7279
Author(s):  
Fred Zin

This paper provides answer to the following question. Does the performance of students depend on the location of accommodation and facilities? The Chi square and the likelihood ratio Chi square statistics based on the contingency table are applied to answer the above question. The statistical analysis using the above techniques revealed that students performance depends on the location of the accommodation and the facilities. Result based on the odd ratio indicated that there is no association between accommodation location and facilities.


1997 ◽  
Author(s):  
O. R. Williams ◽  
K. Bennett ◽  
R. Much ◽  
V. Schönfelder ◽  
J. J. Blom ◽  
...  

Author(s):  
Mridula Joshi ◽  
Sunil Dogra ◽  
Swapnali Mhatre ◽  
Nilesh V Joshi ◽  
Prajakta Rao ◽  
...  

Purpose: The inter-disciplinary approach to practise and also should constantly update their knowledge to keep up with the demands that this field presents. Aim: The aim of this study was to evaluate the knowledge, attitude and practice of Esthetic dentistry amongst the practicing dentists of private dental colleges in Navi Mumbai, through a questionnaire- based study. Materials and Methods: Self-administered KAP (Knowledge, Attitude, Practise) questionnaires were distributed amongst the practicing dentists of private dental colleges in Navi Mumbai. A total of 100 questionnaires were distributed. Statistical analysis used: Pearson’s chi. Sq. test was applied and the likelihood ratio calculated for each question. Independent T Test was applied for equality of means between the groups, i.e. both gender and graduate and post graduate qualifications. Results: Most of the dentists were aware of the field and practise of Esthetic dentistry, although there were some differences found between the general dentists and specialists in adopting and accepting new dental procedures.  According to them, Finances played a major role in opting for an esthetic treatment by patients.   Conclusion: With the advances in esthetic dentistry and increased level of patients’ expectations and awareness, practicing dentists should be well versed with the same, by attending continuing dental education programs and courses to update their skill and knowledge. Also Finances plays a major role in opting for an esthetic treatment.


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