Birth season predicts the values of red blood cell distribution width (RDW) in adulthood

AbstractRecent evidence suggests that red blood cell distribution width (RDW), a simple measure of anisocytosis, may predict the risk of adverse clinical outcomes in both the general population and in patients with severe pathologies. Since it was also shown that the birth season influences the lifetime disease risk, this study was aimed to investigate whether an association may exist between adult RDW values and birth season.The study population consisted in healthy Caucasian blood donors aged 18 or older, undergoing routine laboratory testing before regular blood donation.Overall, 6122 healthy blood donors were included in this study (median age 41 years; 1807 women and 4315 men). Age, sex, mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) but not hemoglobin and hematocrit were found to be independent predictors of RDW. When the study population was classified according to birth season, a significant difference was found for RDW values, but not for age, sex, hemoglobin, hematocrit, MCV and MCH. Subjects born in spring exhibited RDW values generally higher compared to those born in other seasons, reaching statistical significance when compared to those born in summer and winter. In particular, subjects born in spring had a 33% (p=0.014) higher probability of displaying increased RDW values in adulthood compared to those with summer birth.Despite additional studies that are needed to confirm these original findings, the evidence that a significant link exists between birth season and adult anisocytosis provides a plausible explanation for the association between birth season and lifetime disease risk.

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ANALYSIS OF RED BLOOD CELL DISTRIBUTION WIDTH COEFFICIENT OF VARIATION ON STROKE PATIENT

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v25i1.1482 ◽

2019 ◽

Vol 25 (1) ◽

pp. 11

Author(s):

Kartika Paramita ◽

Agus Alim Abdullah ◽

Mansyur Arif

Keyword(s):

Blood Cell ◽

Patient Outcomes ◽

Red Blood Cell ◽

Hemorrhagic Stroke ◽

Secondary Data ◽

Cell Distribution ◽

Cross Sectional ◽

Distribution Width ◽

Significant Difference ◽

Red Blood Cell Distribution

Stroke is a functional disorder attributed to acute focal or global brain injury by vascular cause and persists more than 24 hours. Stroke is divided into ischemic and hemorrhagic strokes. Red Blood Cell Distribution Width (RDW) is a measurement of erythrocyte volume variation in blood circulation. Increased RDW reflects the inflammation that plays a role in the development of atherosclerosis in stroke. This study aims to analyze differences in RDW-CV values in patients with stroke. The design was cross-sectional with a retrospective approach, secondary data from medical records of inpatients with stroke from January to December 2016 at the Dr. Wahidin Sudirohusodo Hospital. The study population consisted of 490 patients aged ≥ 18 years old. The Kruskal-Wallis, Mann-Whitney, and Anova one way tests were used to analyze differences in RDW-CV values in patients with ischemic and hemorrhagic stroke. Mann-Whitney test results showed no significant difference in RDW-CV values between groups of ischemic and hemorrhagic stroke (p 0.96). Kruskal-Wallis and Anova one way tests showed no significant difference in RDW-CV values between four groups of patient outcomes in ischemic and hemorrhagic stroke (p 0.13 and p 0.35 consecutively). There were no significant RDW-CV values between ischemic and hemorrhagic stroke. There was no significant difference between RDW-CV values of four groups of patient outcomes in ischemic and hemorrhagic stroke. RDW-CV values cannot be used to distinguish both ischemic and hemorrhagic stroke, including the prediction of stroke mortality

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Increased red blood cell distribution width in patients with plaque psoriasis

Journal of Medical Biochemistry ◽

10.5937/jomb0-27237 ◽

2020 ◽

Author(s):

Davide Geat

Keyword(s):

Blood Cell ◽

Disease Severity ◽

Red Blood Cell ◽

Plaque Psoriasis ◽

Linear Regression Analysis ◽

Psoriatic Patient ◽

Cell Distribution ◽

Distribution Width ◽

Significant Difference ◽

Red Blood Cell Distribution

Background: Red blood cell distribution width (RDW) is frequently increased in inflammatory disorders and the magnitude of its elevation correlates with disease severity. This study was hence aimed to explore RDW values in patients with psoriasis. Methods: The study population consisted of 366 adult patients with mild to severe plaque psoriasis and 366 age- and sex-matched healthy blood donor controls. For each psoriatic patient demographic, clinical and laboratory data were regularly collected. Results: RDW and MCV were significantly higher in psoriatic patients compared to controls (13.95 vs. 13.40% and 90.4 vs. 89 fL; both p<0.01). In order to assess whether RDW elevations were related to psoriasis severity, we divided our psoriatic patient population into two groups based on a PASI cut-off of 10. No significant differences were observed between the two groups (i.e. PASI > 10 and ≤ 10) in terms of RDW (p=0.36). Adopting different PASI cut-offs (i.e. 3, 5, 7, 12) did also not result in statistically significant differences (p= 0.93, 0.48, 0.22, 0.42, respectively). In linear regression analysis, no significant correlation was also found between RDW and PASI or CRP, nor with age, gender or the psoriasis comorbidities listed in Table I. Furthermore, no significant difference of RDW values was noted between psoriatic patients with and without PsA (p = 0.27). Conclusions: The results of this study confirm that RDW is elevated in psoriatic patients, though the magnitude of its increase did not appear to be associated with disease severity.

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Can Red Blood Cell Distribution Width Predict Laryngectomy Complications or Survival Outcomes?

Annals of Otology Rhinology & Laryngology ◽

10.1177/00034894211056117 ◽

2021 ◽

pp. 000348942110561

Author(s):

Kathryn Marcus ◽

Christopher Blake Sullivan ◽

Zaid Al-Qurayshi ◽

Marisa R. Buchakjian

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Survival Outcomes ◽

Pharyngocutaneous Fistula ◽

Cell Distribution ◽

Distribution Width ◽

Systemic Complications ◽

Case Series Study ◽

Significant Difference ◽

Red Blood Cell Distribution

Objective: Red blood cell distribution width (RDW), a reported biomarker for morbidity and mortality in chronic disease and following certain surgeries, has not been well-studied in head and neck cancer patients. The aim of the study was to examine the association of RDW with postoperative complications and survival among patients who underwent primary or salvage laryngectomy. Methods: We analyzed a retrospective case series study of patients diagnosed with squamous cell carcinoma of the larynx treated with total laryngectomy. Survival outcomes were examined using Kaplan-Meier analysis. Results: One hundred seventy-seven patients were included in the final analysis. The most common tumor subsite was the supraglottis (60%). On bivariate analysis, patients with RDW ≥14.5 had higher prevalence of non-surgical, systemic complications, including deep venous thrombosis, pneumonia, cardiovascular events, and difficulty weaning from mechanical ventilation. However, there was no significant difference in laryngectomy-specific post-operative complications, including pharyngocutaneous fistula, wound infection, stoma complications, and chyle leak. RDW was not found to be associated with survival outcomes following laryngectomy. Conclusions: Among laryngectomy patients, RDW ≥14.5 is associated with higher prevalence of systemic morbidity, but not with specific local surgical complications or decreased survival.

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ANALYSIS OF RED BLOOD CELL DISTRIBUTION WIDTH VALUE TOWARDS FIBROTIC STAGE IN CHRONIC HEPATITIS B

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v25i1.1514 ◽

2018 ◽

Vol 25 (1) ◽

pp. 95

Author(s):

Fatma Idris ◽

Darwati Muhadi ◽

Mutmainah Mutmainah

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B ◽

Blood Cell ◽

Chronic Hepatitis B ◽

Red Blood Cell ◽

Cell Distribution ◽

Distribution Width ◽

Significant Difference ◽

B Virus ◽

Red Blood Cell Distribution

Chronic hepatitis-B is a liver disease caused by hepatitis B virus infection lasting for more than 6 months since the first appearance of signs and symptoms. Red Blood Cell Distribution Width (RDW) is more related to an inflammation process compared to the fibrotic stage. Increase in RDW value results from an increase in erythrocyte destruction or ineffective erythrocyte production caused by the inflammation process. The inflammation can suppress erythrocyte maturation and enable new reticulocytes to be released into blood circulation. Liver inflammation is the characteristic of chronic hepatitis B virus infection. This study aimed to know the RDW value towards the fibrotic stage in chronic hepatitis B patients. This study was a retrospective study conducted in the Dr. Wahidin Sudirohusodo Hospital Makassar. The data were taken from medical records of chronic hepatitis B patients in January 2015-July 2016. The research subjects were chronic hepatitis B patients who underwent routine blood examination for the first time when the patients had just hospitalized. The investigated was continued with fibroscan examination in Gastroenterohepathology Department of the Dr. Wahidin Sudirohusodo General Hospital. Statistical analysis was analyzed with Kruskal-Wallis test using SPSS ver.22. One hundred data of chronic hepatitis B patient consisted of 27 patients without fibrosis, 16 with moderate fibrosis and 11 with severe fibrosis were obtained in this study. Kruskal-Wallis test results showed no significant difference between RDW value with a fibrotic stage in chronic hepatitis B patient (p = 0.255). This study results showed no significant difference between RDW value and fibrotic stage in chronic hepatitis B patients. Red blood cell distribution width value cannot be used as a predictor of liver fibrosis. It is suggested to conduct further studies using larger sample size and more equally distributed sample based on fibrotic stage.

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