Determination of serum calcium levels by 42Ca isotope dilution inductively coupled plasma mass spectrometry

2017 ◽  
Vol 56 (1) ◽  
Author(s):  
Bingqing Han ◽  
Menglei Ge ◽  
Haijian Zhao ◽  
Ying Yan ◽  
Jie Zeng ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Serum Calcium ◽  
Isotope Dilution ◽  
Inductively Coupled Plasma ◽  
Reference Method ◽  
Detection Accuracy ◽  
Serum Samples ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Abstract: Serum calcium level is an important clinical index that reflects pathophysiological states. However, detection accuracy in laboratory tests is not ideal; as such, a high accuracy method is needed.Methods:We developed a reference method for measuring serum calcium levels by isotope dilution inductively coupled plasma mass spectrometry (ID ICP-MS), usingResults:The relative expanded uncertainty of the sample concentration was 0.414% (k=2). The range of repeatability (within-run imprecision), intermediate imprecision (between-run imprecision), and intra-laboratory imprecision were 0.12%–0.19%, 0.07%–0.09%, and 0.16%–0.17%, respectively, for two of the serum samples. SRM909bI, SRM909bII, SRM909c, and GBW09152 were found to be within the certified value interval, with mean relative bias values of 0.29%, −0.02%, 0.10%, and −0.19%, respectively. The range of recovery was 99.87%–100.37%. Results obtained by ID ICP-MS showed a better accuracy than and were highly correlated with those of other reference methods.Conclusions:ID ICP-MS is a simple and accurate candidate reference method for serum calcium measurement and can be used to establish and improve serum calcium reference system in China.

A candidate reference method for serum potassium measurement by inductively coupled plasma mass spectrometry

2017 ◽  
Vol 55 (10) ◽  
Author(s):  
Ying Yan ◽  
Bingqing Han ◽  
Jie Zeng ◽  
Weiyan Zhou ◽  
Tianjiao Zhang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Serum Potassium ◽  
Inductively Coupled Plasma ◽  
Low Cost ◽  
Internal Standard ◽  
Reference Method ◽  
Serum Samples ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

AbstractBackground:Potassium is an important serum ion that is frequently assayed in clinical laboratories. Quality assurance requires reference methods; thus, the establishment of a candidate reference method for serum potassium measurements is important.Methods:An inductively coupled plasma mass spectrometry (ICP-MS) method was developed. Serum samples were gravimetrically spiked with an aluminum internal standard, digested with 69% ultrapure nitric acid, and diluted to the required concentration. TheResults:The correlation coefficients between the measuredConclusions:The new ICP-MS method is specific, precise, simple, and low-cost, and it may be used as a candidate reference method for standardizing serum potassium measurements.

scholarly journals A simplified isotope dilution approach for the U-Pb dating of speleogenic and other low-<sup>232</sup>Th carbonates by multi-collector ICP-MS

2021 ◽  
Author(s):  
Andrew J. Mason ◽  
Anton Vaks ◽  
Sebastian F. M. Breitenbach ◽  
John N. Hooker ◽  
Gideon M. Henderson
Keyword(s):  
Mass Spectrometry ◽  
Isotope Dilution ◽  
Inductively Coupled Plasma ◽  
New Method ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Abstract. We describe a new method for the measurement of U/Pb ratios by isotope dilution multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) for the dating of geologically young clean carbonates, particularly speleothems. The method is intended for materials containing little or no initial 232Th. We illustrate and validate the method with four examples ranging from 0.57 Ma to 20 Ma old. The new method is capable of applying the 235U-207 and 238U-234U-206Pb chronometers, common Pb and quantifiable residual 234U/238U disequilibrium permitting. These provide an alternative to the more widely used 238U-206Pb chronometer, which can be highly inaccurate for samples a few million years old, owing to uncertainties in the excess initial 234U (hence, excess radiogenic 206Pb) commonly observed in speleothems.

Accurate determination of Zn in geological and cosmochemical rock samples by isotope dilution inductively coupled plasma mass spectrometry

2015 ◽  
Vol 30 (2) ◽  
pp. 506-514 ◽  
Author(s):  
Rahat Khan ◽  
Yuta Yokozuka ◽  
Saki Terai ◽  
Naoki Shirai ◽  
Mitsuru Ebihara
Keyword(s):  
Mass Spectrometry ◽  
Isotope Dilution ◽  
Inductively Coupled Plasma ◽  
Accurate Determination ◽  
Rock Samples ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Inductively coupled plasma mass spectrometry (ICP-MS) procedures with isotope dilution were established for the accurate determination of trace Zn (in the level of 10−4to 10−5g g−1) in several tens of mg of geological and cosmochemical rock samples.

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