A candidate reference method for serum potassium measurement by inductively coupled plasma mass spectrometry

2017 ◽  
Vol 55 (10) ◽  
Author(s):  
Ying Yan ◽  
Bingqing Han ◽  
Jie Zeng ◽  
Weiyan Zhou ◽  
Tianjiao Zhang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Serum Potassium ◽  
Inductively Coupled Plasma ◽  
Low Cost ◽  
Internal Standard ◽  
Reference Method ◽  
Serum Samples ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

AbstractBackground:Potassium is an important serum ion that is frequently assayed in clinical laboratories. Quality assurance requires reference methods; thus, the establishment of a candidate reference method for serum potassium measurements is important.Methods:An inductively coupled plasma mass spectrometry (ICP-MS) method was developed. Serum samples were gravimetrically spiked with an aluminum internal standard, digested with 69% ultrapure nitric acid, and diluted to the required concentration. TheResults:The correlation coefficients between the measuredConclusions:The new ICP-MS method is specific, precise, simple, and low-cost, and it may be used as a candidate reference method for standardizing serum potassium measurements.

Determination of serum calcium levels by 42Ca isotope dilution inductively coupled plasma mass spectrometry

2017 ◽  
Vol 56 (1) ◽  
Author(s):  
Bingqing Han ◽  
Menglei Ge ◽  
Haijian Zhao ◽  
Ying Yan ◽  
Jie Zeng ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Serum Calcium ◽  
Isotope Dilution ◽  
Inductively Coupled Plasma ◽  
Reference Method ◽  
Detection Accuracy ◽  
Serum Samples ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Abstract: Serum calcium level is an important clinical index that reflects pathophysiological states. However, detection accuracy in laboratory tests is not ideal; as such, a high accuracy method is needed.Methods:We developed a reference method for measuring serum calcium levels by isotope dilution inductively coupled plasma mass spectrometry (ID ICP-MS), usingResults:The relative expanded uncertainty of the sample concentration was 0.414% (k=2). The range of repeatability (within-run imprecision), intermediate imprecision (between-run imprecision), and intra-laboratory imprecision were 0.12%–0.19%, 0.07%–0.09%, and 0.16%–0.17%, respectively, for two of the serum samples. SRM909bI, SRM909bII, SRM909c, and GBW09152 were found to be within the certified value interval, with mean relative bias values of 0.29%, −0.02%, 0.10%, and −0.19%, respectively. The range of recovery was 99.87%–100.37%. Results obtained by ID ICP-MS showed a better accuracy than and were highly correlated with those of other reference methods.Conclusions:ID ICP-MS is a simple and accurate candidate reference method for serum calcium measurement and can be used to establish and improve serum calcium reference system in China.

Effects of mercury and thallium concentrations on high precision determination of mercury isotopic composition by Neptune Plus multiple collector inductively coupled plasma mass spectrometry

2016 ◽  
Vol 31 (10) ◽  
pp. 2060-2068 ◽  
Author(s):  
Runsheng Yin ◽  
David P. Krabbenhoft ◽  
Bridget A. Bergquist ◽  
Wang Zheng ◽  
Ryan F. Lepak ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Precision ◽  
Inductively Coupled Plasma ◽  
Internal Standard ◽  
Inductively Coupled ◽  
Precision Determination ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
High Precision Determination

Thallium (Tl) has been widely used as an internal standard for mass bias correction during high precision mercury (Hg) isotope ratio measurements using multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS).

An improved candidate reference method for serum potassium measurement by inductively coupled plasma-mass spectrometry

2013 ◽  
Vol 420 ◽  
pp. 146-149 ◽  
Author(s):  
Rui Zhang ◽  
Huaian Ma ◽  
Huiling Li ◽  
Jing Xu ◽  
Jianping Zhang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Serum Potassium ◽  
Inductively Coupled Plasma ◽  
Reference Method ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

A demountable nanoflow nebulizer for sheathless interfacing nano-high performance liquid chromatography with inductively coupled plasma mass spectrometry

2015 ◽  
Vol 30 (9) ◽  
pp. 1927-1934 ◽  
Author(s):  
Lihuan Shen ◽  
Jiannan Sun ◽  
Heyong Cheng ◽  
Jinhua Liu ◽  
Zigang Xu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Inductively Coupled Plasma ◽  
High Performance ◽  
Low Cost ◽  
Dead Volume ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

This work demonstrates a low-cost and demountable nanoflow nebulizer with a small dead volume for stable introduction of liquids at nanoflow rates into ICP-MS.

A Study of Internal Standardization in Inductively Coupled Plasma-Mass Spectrometry

1987 ◽  
Vol 41 (5) ◽  
pp. 801-806 ◽  
Author(s):  
Joseph J. Thompson ◽  
R. S. Houk
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Internal Standard ◽  
Operating Conditions ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Ionization Suppression ◽  
Plasma Mass Spectrometry ◽  
Internal Standardization ◽  
Very High

Internal standardization is employed to compensate for ionization suppression in inductively coupled plasma-mass spectrometry (ICP-MS). By examination of the response of over 50 elements to a sodium matrix under different operating conditions, it is apparent that an internal standard is most effective when it is close in mass and ionization energy to the analyte. The extent of suppression and the relative order of suppression of various analyte elements can differ for various matrix elements. Generally, precision was improved by the use of internal standardization; the extent of improvement differed for different analyte elements and operating conditions. A comparison between ICP-MS with ultrasonic and pneumatic nebulization is described. The ultrasonic nebulizer usually exhibits better sensitivity and detection limits for analyte elements, unless the extent of suppression induced by the concomitant matrix is very high.

scholarly journals Comparison of Selenium Determination in Liver Samples by Atomic Absorption Spectroscopy and Inductively Coupled Plasma–Mass Spectrometry

2005 ◽  
Vol 17 (4) ◽  
pp. 331-340 ◽  
Author(s):  
Irina Rudik Miksa ◽  
Carol L. Buckley ◽  
Nancy P. Carpenter ◽  
Robert H. Poppenga
Keyword(s):  
Mass Spectrometry ◽  
Atomic Absorption ◽  
Absorption Spectroscopy ◽  
Atomic Absorption Spectroscopy ◽  
Inductively Coupled Plasma ◽  
Internal Standard ◽  
Magnesium Nitrate ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Selenium (Se) is an essential trace element that is often deficient in the natural diets of domestic animal species. The measurement of Se in whole blood or liver is the most accurate way to assess Se status for diagnostic purposes. This study was conducted to compare hydride generation atomic absorption spectroscopy (HG-AAS) with inductively coupled plasma–mass spectrometry (ICP-MS) for the detection and quantification of Se in liver samples. Sample digestion was accomplished with magnesium nitrate and nitric acid for HG-AAS and ICP-MS, respectively. The ICP-MS detection was optimized for 82Se with yttrium used as the internal standard and resulted in a method detection limit of 0.12 μg/g. Selenium was quantified by both methods in 310 samples from a variety of species that were submitted to the Toxicology Laboratory at New Bolton Center (Kennett Square, PA) for routine diagnostic testing. Paired measurements for each sample were evaluated by a mean difference plot method. Limits of agreement were used to describe the maximum differences likely to occur between the 2 methods. Results suggest that under the specified conditions ICP-MS can be reliably used in place of AAS for quantitation of tissue Se at or below 2 μg/g to differentiate between adequate and deficient liver Se concentrations.

scholarly journals Multielemental Analysis of Food and Agricultural Matrixes by Inductively Coupled Plasma-Mass Spectrometry

2002 ◽  
Vol 85 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Francesco Cubadda ◽  
Andrea Andrea ◽  
Antonella Testoni ◽  
Fabio Fabio
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Internal Standard ◽  
Multielemental Analysis ◽  
Inductively Coupled ◽  
Analytical Protocol ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Staple Foods ◽  
Correction Equations

Abstract The suitability of quadrupole inductively coupled plasma-mass spectrometry (ICP-MS) for multielemental analysis of food following microwave closed vessel digestion of samples was evaluated in relation to analytical challenges presented by some major food and agricultural matrixes. Fifteen key analytes (Al, As, Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, Se, Sn, V, Zn) were determined in 9 reference materials representative of 3 major groups of staple foods (cereals, seafood, and meat). For all measurements, the method of external calibration was used and Rh was selected as internal standard. Matrix-induced interferences were evaluated for each material, and suitable methods to overcome them were applied. Spectral interferences caused by C, Cl, and Ca content of digestates were quantitated and corrected by entering a simple system of mathematical correction equations into the instrument software before each analytical run. Full mastering of interferences together with adoption of a series of measures to control the reliability of analytical measurements produced accurate results for all the analytes. A standard analytical protocol is outlined for the benefit of both research and routine high-throughput laboratories that perform ICP-MS analyses of food.

scholarly journals The individual analysis of fluid inclusions in minerals using Laser Ablation Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS): an evaluation

2001 ◽  
Vol 3 (3-4) ◽  
pp. 215-230
Author(s):  
Wouter HEIJLEN ◽  
Philippe MUCHEZ
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Fluid Inclusions ◽  
Inductively Coupled Plasma ◽  
Internal Standard ◽  
Natural Quartz ◽  
Inductively Coupled ◽  
Ms Analysis ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

During the last decade, the possible application of laser ablation inductively coupled plasma - mass spectrometry (LA-ICP-MS) as a quantitative technique for the analysis of individual fluid inclusions has been intensely studied. The quantitative ability of this technique is, however, complicated by several fractionation processes that operate during ablation, transport and analysis in the ICP-MS. In the present study, a number of these fractionation effects were studied and the quantitative ability of LA-ICP-MS analysis of fluid inclusions in natural quartz is evaluated. Using NIST SRM 612 and 614 as reference materials, it is shown that the fractionation during transport is minimised when the sample cell is flushed with He, in contrast with the set-up where Ar is used. Calcium has been successfully applied as an internal standard to calibrate the REE in NIST-glasses. The use of Ca to calibrate other lithophile and chalcophile elements, such as K, Zn, Cu and Pb, can however be questioned. It is shown that the technique is capable of semi-quantitatively characterising different fluid inclusion populations in natural quartz, which demonstrates its importance as a tool for palaeofluidflow modelling. However, during LA-ICP-MS analysis of fluid inclusions in natural quartz, elements are reprecipitated in a glassy phase, as shown by SEM-EDX analysis of the sample surface after ablation. This process could result in a fractionation and may account for the poor precision of the analysis.

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