Total Corneal Transplantation after Trauma

Abstract The first successful corneal transplantation is known since 1905, performed by Eduard Zirm (2). It has been implemented in order to restore vision in a variety of corneal diseases and after ocular traumas. The traditional technique for corneal transplantation, penetrating keratoplasty (PKP), refers to the full-thickness replacement of corneal tissue with a healthy donor graft (1). Authors report a well-documented case about successfully transplanted cornea after penetrating ocular trauma to improve visual outcome.

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Gamma-Irradiated Cornea in Combat-related Ocular Trauma

Military Medicine ◽

10.1093/milmed/usaa479 ◽

2020 ◽

Author(s):

Brian M Davis ◽

Carson Clabeaux ◽

Anton Vlasov ◽

Paul Houghtaling

Keyword(s):

Ocular Trauma ◽

Cost Savings ◽

Corneal Tissue ◽

Significant Cost ◽

Visual Rehabilitation ◽

Military Health ◽

Corneal Injury ◽

Gamma Irradiated ◽

The Military ◽

Penetrating Ocular Trauma

ABSTRACT Corneal injury is a known risk for deployed troops worldwide. To the authors’ knowledge, there has been no reported use of gamma-irradiated corneas in the setting of severe corneal trauma. Our report highlights the case of a 36-year-old active duty solider who sustained bilateral penetrating ocular trauma from a nearby ordnance explosion. We propose that ocular surgeons should consider utilizing gamma-irradiated corneas in (1) a situation where the corneal tissue is so damaged that it would be challenging to accomplish an adequate repair while providing the opportunity for future visual rehabilitation and (2) remote and/or deployed environments where storage of fresh donor tissue is limited. The long shelf life of gamma-irradiated corneas reduces the need for specialized storage equipment and the need for continuous resupply, both potentially leading to significant cost savings for the Military Health System.

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Penetrating keratoplasty for treatment of corneal abscesses in horses – case report

Acta Veterinaria Brno ◽

10.2754/avb201382030303 ◽

2013 ◽

Vol 82 (3) ◽

pp. 303-307

Author(s):

Zita Makra ◽

Imre Biksi ◽

Gábor Bodó

Keyword(s):

Case Report ◽

Surgical Technique ◽

Medical Therapy ◽

Penetrating Keratoplasty ◽

Corneal Stroma ◽

Surgical Removal ◽

Full Thickness ◽

Effective Technique ◽

Corneal Incision ◽

Donor Graft

This case report describes the surgical technique and outcome of allograft transplantation to treat full thickness corneal abscesses in three horses. In all three cases penetrating keratoplasty was performed. Each affected eye had an abscess within the corneal stroma. An initial full thickness circular corneal incision was made around the lesion. After excision of the stromal abscess the created defect was replaced with a larger diameter full thickness donor graft and the initial corneal incision was repaired. All of the horses that underwent penetrating keratoplasty procedure healed with a scar at the graft site and remained visual. Penetrating keratoplasty is an effective technique for surgical removal of medically nonresponsive full thickness stromal abscess in horses and results in a visual and cosmetically acceptable globe. The advantages of this technique compared to medical therapy are that there is less scarring, shorter healing times and less damage of the globe because of the concurrent uveitis. To the authors’ knowledge, clinical experience with penetrating keratoplasty in horses has not been reported in Europe so far.

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Prospects and Challenges of Translational Corneal Bioprinting

Bioengineering ◽

10.3390/bioengineering7030071 ◽

2020 ◽

Vol 7 (3) ◽

pp. 71 ◽

Cited By ~ 2

Author(s):

Matthias Fuest ◽

Gary Hin-Fai Yam ◽

Jodhbir S. Mehta ◽

Daniela F. Duarte Campos

Keyword(s):

Tissue Engineering ◽

Ex Vivo ◽

Corneal Transplantation ◽

Human Cornea ◽

Corneal Tissue ◽

Full Thickness ◽

Future Directions ◽

Spatial Control

Corneal transplantation remains the ultimate treatment option for advanced stromal and endothelial disorders. Corneal tissue engineering has gained increasing interest in recent years, as it can bypass many complications of conventional corneal transplantation. The human cornea is an ideal organ for tissue engineering, as it is avascular and immune-privileged. Mimicking the complex mechanical properties, the surface curvature, and stromal cytoarchitecure of the in vivo corneal tissue remains a great challenge for tissue engineering approaches. For this reason, automated biofabrication strategies, such as bioprinting, may offer additional spatial control during the manufacturing process to generate full-thickness cell-laden 3D corneal constructs. In this review, we discuss recent advances in bioprinting and biomaterials used for in vitro and ex vivo corneal tissue engineering, corneal cell-biomaterial interactions after bioprinting, and future directions of corneal bioprinting aiming at engineering a full-thickness human cornea in the lab.

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Penetrating ocular trauma and visual outcome

Insight - the Journal of the American Society of Ophthalmic Registered Nurses ◽

10.1016/s1060-135x(96)90012-3 ◽

1996 ◽

Vol 21 (4) ◽

pp. 133-134

Author(s):

L Hunt

Keyword(s):

Ocular Trauma ◽

Visual Outcome ◽

Penetrating Ocular Trauma

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Primary posterior chamber IOL implantation in penetrating ocular trauma

International Ophthalmology ◽

10.1007/bf00942927 ◽

1993 ◽

Vol 17 (3) ◽

pp. 137-141 ◽

Cited By ~ 13

Author(s):

Tat Keong Chan ◽

Graeme Mackintosh ◽

Ronald Yeoh ◽

Arthur SM Lim

Keyword(s):

Ocular Trauma ◽

Posterior Chamber ◽

Iol Implantation ◽

Penetrating Ocular Trauma ◽

Posterior Chamber Iol

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A Method for Performing Full-Thickness, Orthotopic, Penetrating Keratoplasty in the Mouse

Ophthalmic Surgery Lasers and Imaging Retina ◽

10.3928/1542-8877-19901101-08 ◽

1990 ◽

Vol 21 (11) ◽

pp. 781-785

Author(s):

Si-Chun She ◽

Lance P Steahly ◽

Edward J Moticka

Keyword(s):

Penetrating Keratoplasty ◽

Full Thickness

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Primary surgical options for acute corneal hydrops: A review

European Journal of Ophthalmology ◽

10.1177/11206721211037833 ◽

2021 ◽

pp. 112067212110378

Author(s):

Gonzalo García de Oteyza ◽

Guido Bregliano ◽

Irene Sassot ◽

Luis Quintana ◽

Carolina Rius ◽

...

Keyword(s):

Visual Acuity ◽

Medical Therapy ◽

Penetrating Keratoplasty ◽

Corneal Transplantation ◽

Corneal Edema ◽

Self Healing ◽

Surgical Options ◽

Corneal Hydrops

Acute corneal hydrops usually resolves alone or with medical therapy along the first 4–6 weeks. However, depending on the severity of the corneal edema or the size of the Descemet break, self-healing might be difficult. Years ago, those patients had no more options than corneal transplantation, but surgical alternatives are on the rise in this century. These surgeries are becoming more popular with a variety of techniques relegating penetrating keratoplasty to a residual role. These techniques aim to accelerate corneal healing, reduce the edema, improve visual acuity and prevent from severe complications that may appear if corneal hydrops is not treated rapidly. Feasibility and safety are the favorable aspects of these techniques since the complications rates described remain low. In this review, we emphasize the recently published studies that describe both the techniques and their results.

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