Temperature-responsive hydrogels containing new LCST methacrylate macromonomers

e-Polymers ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Anna Korytkowska-Wałach ◽  
Anna Porwoł ◽  
Mirosław Gibas
Keyword(s):  
Phase Transition ◽  
Biomedical Applications ◽  
Tetraethylene Glycol ◽  
Temperature Sensitive ◽  
Hydroxyethyl Methacrylate ◽  
Temperature Responsive ◽  
Michael Type Addition ◽  
Responsive Hydrogels ◽  
Ether Ester ◽  
Gel Transition

AbstractA series of hydrogels were synthesized: homopolymers of new temperature-sensitive methacrylate macromonomers of ether-ester structure, derived from monomethacrylate of tetraethylene glycol via Michael-type addition - oligo(TTEGMMA), and copolymers of oligo(TTEGMMA) with N-isopropylacrylamide (NIPAAm) or 2-hydroxyethyl methacrylate (HEMA). Hydrogels based on oligo(TTEGMMA) demonstrate broad volume phase transition. Combination of oligo(TTEGMMA) with NIPAAm or HEMA yielded hydrogels having narrower phase transition and lower gel transition temperature (LGTT) up to 43 °C at the most, which is in the range of interest for most biomedical applications.

scholarly journals Zinc diethyldithiocarbamate as a catalyst for synthesising biomedically-relevant thermogelling polyurethanes

2020 ◽  
Vol 1 (9) ◽  
pp. 3221-3232
Author(s):  
Jason Y. C. Lim ◽  
Qianyu Lin ◽  
Connie K. Liu ◽  
Liangfeng Guo ◽  
Kun Xue ◽  
...  
Keyword(s):  
Transition Temperatures ◽  
Temperature Responsive ◽  
Zinc Diethyldithiocarbamate ◽  
Responsive Hydrogels ◽  
Gel Transition

Zinc diethyldithiocarbamate (ZDTC) is shown to catalyse the synthesis of polyurethanes, which are able to self-assemble in water to form temperature-responsive hydrogels with low sol-to-gel transition temperatures.

scholarly journals Smart pH/temperature Sensitive Hydrogels with Tailored Transition Temperature

2017 ◽  
Vol 57 (2) ◽  
Author(s):  
Rodolfo Salgado-Rodríguez ◽  
Ángel Licea-Claverie ◽  
Arturo Zizumbo-López ◽  
Karl-Friedrich Arndt
Keyword(s):  
Phase Transition ◽  
Transition Temperature ◽  
Phase Transition Temperature ◽  
Biomedical Applications ◽  
Temperature Sensitive ◽  
Swelling Capacity ◽  
Critical Ph ◽  
Comonomer Content ◽  
Type Of Transition ◽  
Specific Phase

Dual pH- and temperature-sensitive hydrogels have been prepared based on N-isopropylacrylamide (NIPAAm) and either potassium 5-methacryloyloxy-pentanoate (M4K) or potassium11-methacryloyloxy-undecanoate (M10K) as comonomers. The gels containing M10K (longer methylene chain) showed a slightly lower swelling capacity than the gels containing M4K. Hydrogels were produced with specific phase transition temperature (T<sub>cr</sub>) in the range from 12 to 76 oC for NIPAAm-C4 hydrogels (containing M4K) and from 16 to 36 oC for NIPAAm-C10 hydrogels (containing M10K) by controlling: the type and comonomer content, and the pH of water. The type of transition changes from discontinuous (below the critical pH of the acid comonomer) to continuous (above de critical pH of the acid comonomer). The title hydrogel materials are promising candidates for biomedical applications.

Synthesis of functionalized-thermo responsive-water soluble co-polymer for conjugation to protein for biomedical applications

2013 ◽  
Vol 1498 ◽  
pp. 121-125
Author(s):  
Ali Fathi ◽  
Hua Wei ◽  
Wojciech Chrzanowski ◽  
Anthony S. Weiss ◽  
Fariba Dehghani
Keyword(s):  
Biomedical Applications ◽  
Room Temperature ◽  
Aqueous Media ◽  
Ester Group ◽  
Biological Properties ◽  
Water Soluble ◽  
Hydroxyethyl Methacrylate ◽  
Musculoskeletal Tissue ◽  
Temperature Responsive ◽  
Model Protein

ABSTRACTThe aim of this study was to develop a thermo-responsive and bioactive polymer with suitable mechanical properties for musculoskeletal tissue engineering applications. A copolymer was synthesized that comprised of hydrophilic polyethylene glycol, thermo responsive N-isopropylacrylamide (NIPAAm), 2-hydroxyethyl methacrylate-poly(lactide) (HEMA-PLA) to enhance mechanical strength and an active N-acryloxysuccinimide (NAS) group for conjugation to proteins to enhance biological properties. A model protein such as elastin was used to assess the feasibility of conjugating this polymer to protein. The results of 1HNMR analyses confirmed that random polymerization was viable technique for synthesis of this copolymer. The co-polymers synthesized with PEG content of 3 mol% were water soluble. A hydrogel was created by dissolving the copolymer and elastin below room temperature in aqueous media, followed by rapid gelation at 37°C. The results of Fourier transform infrared analyses confirmed the conjugation of protein to copolymer due to significant reduction of ester group absorption (1735 cm−1). This data confirmed molecular interaction between protein and the temperature responsive co-polymer. Our preliminary results demonstrated that it is viable to tune different properties of this hydrogel by changing the composition of co-polymer.

Exploration of the unusual two-step volume phase transition of the poly(N-vinylcaprolactam-co-hydroxyethyl methacrylate) hydrogel

2018 ◽  
Vol 20 (35) ◽  
pp. 23013-23024 ◽  
Author(s):  
Gehong Su ◽  
Liyang Jia ◽  
Xueqian Zhang ◽  
Yulin Zhang ◽  
Pengchi Deng ◽  
...  
Keyword(s):  
Phase Transition ◽  
Biomedical Applications ◽  
Volume Phase Transition ◽  
Hydroxyethyl Methacrylate ◽  
Volume Phase ◽  
Transition Mechanism ◽  
Stimuli Sensitive

It is important to investigate the phase transition mechanism of stimuli-sensitive hydrogels due to its great guiding significance for the application of stimuli-sensitive hydrogels in biomedical applications.

A temperature-responsive supramolecular hydrogel: preparation, gel–gel transition and molecular aggregation

Soft Matter ◽  
2018 ◽  
Vol 14 (16) ◽  
pp. 3090-3095 ◽  
Author(s):  
Lin Wang ◽  
Xuefeng Shi ◽  
Jinben Wang
Keyword(s):  
Phase Transition ◽  
Gemini Surfactant ◽  
Molecular Aggregation ◽  
Supramolecular Hydrogel ◽  
Temperature Responsive ◽  
Gel Phase ◽  
Reversible Gel ◽  
Gel Transition

A supramolecular hydrogel based on a gemini surfactant exhibits a reversible gel–gel phase transition and the turbid hydrogel possesses more compacted assemblies than the transparent one.

scholarly journals Quantifying the bending of bilayer temperature-sensitive hydrogels

2017 ◽  
Vol 473 (2200) ◽  
pp. 20170092 ◽  
Author(s):  
Chenling Dong ◽  
Bin Chen
Keyword(s):  
Finite Deformation ◽  
Deformation Theory ◽  
Mechanical Performance ◽  
Temperature Sensitive ◽  
Stimuli Responsive ◽  
Optimal Thickness ◽  
Change Analysis ◽  
Temperature Responsive ◽  
Finite Deformation Theory ◽  
Responsive Hydrogels

Stimuli-responsive hydrogels can serve as manipulators, including grippers, sensors, etc., where structures can undergo significant bending. Here, a finite-deformation theory is developed to quantify the evolution of the curvature of bilayer temperature-sensitive hydrogels when subjected to a temperature change. Analysis of the theory indicates that there is an optimal thickness ratio to acquire the largest curvature in the bilayer and also suggests that the sign or the magnitude of the curvature can be significantly affected by pre-stretches or small pores in the bilayer. This study may provide important guidelines in fabricating temperature-responsive bilayers with desirable mechanical performance.

Dual pH and temperature responsive hydrogels based on β-cyclodextrin derivatives for atorvastatin delivery

2016 ◽  
Vol 136 ◽  
pp. 300-306 ◽  
Author(s):  
Kaiwen Yang ◽  
Sicheng Wan ◽  
Binbin Chen ◽  
Wenxia Gao ◽  
Jiuxi Chen ◽  
...  
Keyword(s):  
Cyclodextrin Derivatives ◽  
Temperature Responsive ◽  
Responsive Hydrogels
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