Dual pH and temperature responsive hydrogels based on β-cyclodextrin derivatives for atorvastatin delivery

AbstractA series of hydrogels were synthesized: homopolymers of new temperature-sensitive methacrylate macromonomers of ether-ester structure, derived from monomethacrylate of tetraethylene glycol via Michael-type addition - oligo(TTEGMMA), and copolymers of oligo(TTEGMMA) with N-isopropylacrylamide (NIPAAm) or 2-hydroxyethyl methacrylate (HEMA). Hydrogels based on oligo(TTEGMMA) demonstrate broad volume phase transition. Combination of oligo(TTEGMMA) with NIPAAm or HEMA yielded hydrogels having narrower phase transition and lower gel transition temperature (LGTT) up to 43 °C at the most, which is in the range of interest for most biomedical applications.

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Preparation and properties of fast temperature-responsive soy protein/PNIPAAm IPN hydrogels

Journal of the Serbian Chemical Society ◽

10.2298/jsc130219047l ◽

2014 ◽

Vol 79 (2) ◽

pp. 211-224 ◽

Cited By ~ 4

Author(s):

Yong Liu ◽

Yingde Cui ◽

Guojie Wu ◽

Miaochan Liao

Keyword(s):

Soy Protein ◽

Polymer Network ◽

Reaction Medium ◽

Interpenetrating Polymer Network ◽

Fickian Diffusion ◽

Gravimetric Analysis ◽

Scanning Calorimetry ◽

Temperature Responsive ◽

Swelling Mechanism ◽

Responsive Hydrogels

The interpenetrating polymer network of fast temperature-responsive hydrogels based on soy protein and poly(N-isopropylacrylamide) were successfully prepared using the sodium bicarbonate (NaHCO3) solutions as the reaction medium. The structure and properties of the hydrogels were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry and thermal gravimetric analysis. The swelling and deswelling kinetics were also investigated in detail. The results have shown that the proposed hydrogels had high porous structure, good miscibility and thermal stability, and fast temperature responsivity. The presence of NaHCO3 had little effect on the volume phase transition temperature (VPTT) of the hydrogels, and the VPTTs were at about 32?C. Compared with the traditional hydrogels, the proposed hydrogels had much faster swelling and deswelling rate. The swelling mechanism of the hydrogels was the non-Fickian diffusion. This fast temperature-responsive hydrogels may have potential applications in the field of biomedical materials.

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Preparation and characterization of pH- and temperature-responsive hydrogels with surface-functionalized graphene oxide as the crosslinker

Soft Matter ◽

10.1039/c2sm07012j ◽

2012 ◽

Vol 8 (11) ◽

pp. 3139 ◽

Cited By ~ 57

Author(s):

Zhiqiang Li ◽

Jianfeng Shen ◽

Hongwei Ma ◽

Xin Lu ◽

Min Shi ◽

...

Keyword(s):

Graphene Oxide ◽

Functionalized Graphene ◽

Functionalized Graphene Oxide ◽

Temperature Responsive ◽

Responsive Hydrogels

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CULTIVATION OF CHONDROCYTES AND MENISCUS CELLS IN THERMO-RESPONSIVE HYDROGELS CONTAINING CHITOSAN AND HYALURONIC ACID UNDER MECHANICAL TENSILE STIMULATION

Journal of Mechanics in Medicine and Biology ◽

10.1142/s021951941100485x ◽

2011 ◽

Vol 11 (05) ◽

pp. 1003-1015 ◽

Cited By ~ 3

Author(s):

JYH-PING CHEN ◽

HAN-TSUNG LIAO ◽

TAI-HONG CHENG

Keyword(s):

Cell Proliferation ◽

Hyaluronic Acid ◽

Tensile Strain ◽

Biosynthetic Activity ◽

Hydrogel Scaffold ◽

Primary Chondrocytes ◽

Temperature Responsive ◽

Mechanical Tensile ◽

Meniscus Cells ◽

Responsive Hydrogels

Temperature-responsive hydrogel scaffold containing chitosan and hyaluronic acid was used to entrap primary chondrocytes and meniscus cells. The effect of dynamic tensile strain on the cells/hydrogel constructs was evaluated by measuring cell proliferation, biosynthetic activity, and viability. The results demonstrated that mechanical deformation applied at 15% tensile strain, 0.5 Hz, and 10 min per day for 43 days resulted in substantial increases in glycosaminoglycan (36% for chondrocytes and 31% for meniscus cells) and collagen productions (37% for chondrocytes and 52% for meniscus cells) over static controls while not significantly affecting cell proliferation and viability.

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Zinc diethyldithiocarbamate as a catalyst for synthesising biomedically-relevant thermogelling polyurethanes

Materials Advances ◽

10.1039/d0ma00734j ◽

2020 ◽

Vol 1 (9) ◽

pp. 3221-3232

Author(s):

Jason Y. C. Lim ◽

Qianyu Lin ◽

Connie K. Liu ◽

Liangfeng Guo ◽

Kun Xue ◽

...

Keyword(s):

Transition Temperatures ◽

Temperature Responsive ◽

Zinc Diethyldithiocarbamate ◽

Responsive Hydrogels ◽

Gel Transition

Zinc diethyldithiocarbamate (ZDTC) is shown to catalyse the synthesis of polyurethanes, which are able to self-assemble in water to form temperature-responsive hydrogels with low sol-to-gel transition temperatures.

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