Graphisins A and B from the Lichen Graphis tetralocularis
Keyword(s):
Crude extracts of the lichen Graphis tetralocularis exhibited antimycobacterial activity, with minimum inhibitory concentration (MIC) values in a range of 100–200 μg mL–1. Chemical investigation of the broth led to the isolation of acremonidin E (1) and graphisins A (2) and B (3). Acremonidin E (1) displayed antitubercular activity with MIC values of 50 μg mL–1 and showed cytotoxicity against BC, KB, and NCI-H187 cell lines with IC50 values of 12.79–27.12 μg mL–1, whereas graphisins A (2) and B (3) were inactive to these tests.
1994 ◽
Vol 59
(1)
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pp. 234-238
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2015 ◽
Vol 10
(4)
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pp. 1934578X1501000
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2016 ◽
Vol 8
(12)
◽
pp. 252
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Keyword(s):