1,25-Dihydroxyvitamin D3 and type 2 diabetes: Ca2+-dependent molecular mechanisms and the role of vitamin D status

1. We have used pigs with inherited vitamin D-dependent rickets type 1 to study the effect of 1,25-dihydroxyvitamin D deficiency on the metabolic clearance rate of 3H-1,25-dihydroxyvitamin D3 infused to steady-state levels in plasma. 2. Plasma levels of 1,25-dihydroxyvitamin D were 24 ± 1 (sem) pmol/l in the hypocalcaemic, homozygous piglets and 196 ± 27 pmol/l in their normocalcaemic, heterozygous siblings. 3. The metabolic clearance rate of 1,25-dihydroxyvitamin D3 was the same in both normal heterozygous (0.90 ± 0.02) and hypocalcaemic, homozygous piglets (0.90±0.01 ml−1 min−1 kg−1 metabolic bodysize). 4. We conclude that a deficiency of circulating 1,25-dihydroxyvitamin D does not influence the clearance of 1,25-dihydroxyvitamin D3 from the circulation of pigs.

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Vitamin D Deficiency Is Associated with the Presence and Severity of Diabetic Retinopathy in Type 2 Diabetes Mellitus

Journal of Diabetes Research ◽

10.1155/2015/374178 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 23

Author(s):

Nuria Alcubierre ◽

Joan Valls ◽

Esther Rubinat ◽

Gonzalo Cao ◽

Aureli Esquerda ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Diabetic Retinopathy ◽

Vitamin D Deficiency ◽

Vitamin D Status ◽

25 Hydroxy Vitamin D ◽

Advanced Stages

There is very few evidences on the role of vitamin D in the development of diabetic retinopathy. The aim of the current study was to explore whether there is an association of vitamin D status and diabetic retinopathy in type 2 diabetes. Two groups of patients were selected: 139 and 144 patients with and without retinopathy, respectively, as assessed by an experienced ophthalmologist. Subjects with advanced late diabetic complications were excluded to avoid confounding biases. 25-Hydroxy-vitamin D3(25(OH)D) concentrations and vitamin D deficiency were associated with the presence of diabetic retinopathy. Additionally, patients with more advanced stages of retinopathy (grades 2–4) had lower concentrations of 25(OH)D and were more frequently vitamin D deficient as compared with patients not carrying this eye complication. In conclusion, our study confirms the association of vitamin D deficiency with the presence and severity of diabetic retinopathy in type 2 diabetes. Further experimental and prospective studies on this issue are clearly warranted.

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Low Levels of 25-Hydroxy Vitamin D and Active 1,25-Dihydroxyvitamin D Independently Associated with Type 2 Diabetes Mellitus in Older Australian Men: The Concord Health and Ageing in Men Project

Journal of the American Geriatrics Society ◽

10.1111/jgs.12975 ◽

2014 ◽

Vol 62 (9) ◽

pp. 1741-1747 ◽

Cited By ~ 17

Author(s):

Vasant Hirani ◽

Robert G. Cumming ◽

David G. Le Couteur ◽

Vasikaran Naganathan ◽

Fiona Blyth ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

25 Hydroxy Vitamin D ◽

Low Levels

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A role of vitamin D in low-intensity chronic inflammation and insulin resistance in type 2 diabetes mellitus?

Nutrition Research Reviews ◽

10.1079/nrr2005104 ◽

2005 ◽

Vol 18 (2) ◽

pp. 175-182 ◽

Cited By ~ 28

Author(s):

Mario Flores

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Chronic Inflammation ◽

Vitamin D Status ◽

Low Intensity

Evidence from different directions, including observational and experimental studies, points to a role of vitamin D status in low-intensity chronic inflammation and insulin resistance in type 2 diabetes mellitus (T2DM). It has been recognised that insulin resistance and low-intensity chronic inflammation are risk factors for T2DM. Thus, vitamin D status can be implicated in the aetiology of TD2M. It is suggested that the relationship between vitamin D and low-intensity chronic inflammation and insulin resistance in T2DM can be mediated in part by the immune-modulating properties of the active form of vitamin D (1-α,25-dihydroxyvitamin D3; 1,25(OH)2D3), which is able to down regulate the production of pro-inflammatory cytokines – particularly TNF-α, and IL-6. However, an association between vitamin D status and these features, which is independent of BMI, has been also reported. Non-calcaemic effects of vitamin D can be associated with health outcomes other than those traditionally attributed to the vitamin.

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588-P: Vitamin D Status in a Bulgarian Population with Type 2 Diabetes and Diabetic Foot Ulcers

Diabetes ◽

10.2337/db20-588-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 588-P

Author(s):

ANI S. TODOROVA ◽

RUMYANA DIMOVA ◽

NEVENA CHAKAROVA ◽

MINA SERDAROVA ◽

GRETA GROZEVA-DAMYANOVA ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Diabetic Foot ◽

Foot Ulcers ◽

Diabetic Foot Ulcers ◽

Vitamin D Status ◽

Bulgarian Population

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Faculty Opinions recommendation of The relationship between vitamin D status and cardiac autonomic neuropathy in patients with type 2 diabetes mellitus.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725663048.793517676 ◽

2016 ◽

Author(s):

Rayaz Malik

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Autonomic Neuropathy ◽

Cardiac Autonomic Neuropathy ◽

Vitamin D Status ◽

The Relationship

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Vitamin D Status in a Bulgarian Population With Type 2 Diabetes and Diabetic Foot Ulcers

The International Journal of Lower Extremity Wounds ◽

10.1177/1534734620965820 ◽

2020 ◽

pp. 153473462096582

Author(s):

Ani S. Todorova ◽

Edward B. Jude ◽

Rumyana B. Dimova ◽

Nevena Y. Chakarova ◽

Mina S. Serdarova ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Peripheral Neuropathy ◽

Diabetic Foot ◽

Diabetic Peripheral Neuropathy ◽

Foot Ulcers ◽

Diabetic Foot Ulcers ◽

Vitamin D Status ◽

Active Infection

The aim of this study was to assess vitamin D status in patients with type 2 diabetes and diabetic foot ulcers (DFU). A total of 242 participants with type 2 diabetes, mean age 59.1 ± 10 years, mean body mass index 31.4 ± 6.3 kg/m2, and estimated glomerular filtration rate ≥45 mL/min/1.73m2, were divided into 2 groups: 73 with DFU (35 with and 38 without active infection) and 169 without DFU (106 with diabetic peripheral neuropathy, 63 without complications). Neuropathy was assessed by 10 g monofilament, Rydel-Seiffer 128 Hz tuning fork, and temperature discrimination. Serum 25(OH)D (25-hydroxy vitamin D) was assessed by ECLIA (electro-chemiluminescence immunoassay) method. Median 25(OH)D level was 12.6 ng/mL (IQR [interquartile range] 9.3-17.6 ng/mL) in the studied cohort. The DFU group presented with lower 25(OH)D level as compared with diabetic patients without foot ulcers (non-DFU group): 11.6 ng/mL (IQR 8.5-15.8 ng/mL) versus 13.5 ng/mL (IQR 9.6-18.6 ng/mL), P = .001; the diabetic peripheral neuropathy subgroup demonstrated lower 25(OH)D level in comparison with participants without complications: 12.5 ng/mL (IQR 9-17.2 ng/mL) versus 15.9 ng/mL (IQR 10.4-20.8 ng/mL), P = .031. This remained significantly different even after correction for age and duration of diabetes. There was no difference in 25(OH)D level between the subgroups according to the presence of active infection. In conclusion, vitamin D deficiency may play a role in the development of diabetes complications.

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