Role of androgens in modulating male and female sexual function

2010 ◽  
Vol 4 (1) ◽  
Author(s):  
Abdulmaged M. Traish
Keyword(s):  
Animal Models ◽  
Sexual Health ◽  
Sexual Function ◽  
Sexual Desire ◽  
Clinical Studies ◽  
Androgen Deficiency ◽  
Fiber Network ◽  
Men And Women ◽  
Corpora Cavernosa

AbstractAdvancement in basic and clinical research has provided considerable evidence suggesting a key role of androgens in the physiology and pathophysiology of sexual function. Evidence from clinical studies in men and women with androgen deficiency support a role of androgens in maintaining sexual function in men and women and are integral in maintaining sexual health. Preclinical studies utilizing male animal models demonstrated a role of androgens in maintenance of: (i) penile tissue structural integrity, (ii) penile trabecular smooth muscle growth and function, (iii) integrity of penile nerve fiber network, (iv) signaling pathways in the corpora cavernosa, (v) myogenic and adipogenic differentiation in the corpora cavernosa, (vi) physiological penile response to stimuli, and (vii) facilitating corporeal hemodynamics. These findings strongly suggest a role for androgen in the physiology of penile erection. In addition, clinical studies in hypogonadal men with erectile dysfunction treated with testosterone provided invaluable information on restoring erectile function and improving ejaculatory function. Similarly, clinical studies in surgically or naturally postmenopausal women with androgen deficiency suggested that androgens are important for maintaining sexual desire and testosterone treatment was shown to improve sexual desire, arousal and orgasm. Furthermore, studies in female animal models demonstrated that androgens maintain the integrity of vaginal nerve fiber network, muscularis volume, and enhance genital blood flow and mucification. Based on the biochemical, physiological and clinical findings from human and animal studies, we suggest that androgens are integral for maintaining sexual function and play a critical role in maintaining sexual health in men and women.

The Effects of Herbal Medicines on Women Sexual Dysfunction: A Systematic Review

2020 ◽  
Vol 17 ◽  
Author(s):  
Tahereh Molkara ◽  
Maliheh Motavasselian ◽  
Farideh Akhlaghi ◽  
Mohammad Arash Ramezani ◽  
Hamideh Naghedi Baghdar ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Herbal Medicine ◽  
Sexual Health ◽  
Sexual Function ◽  
Psychological Health ◽  
Health Management ◽  
Herbal Medicines ◽  
Physical And Psychological Health ◽  
Female Sexual Response

: Sexual health plays an important role in the women’s health and quality of life. Sexual health management is a prerequisite for physical and psychological health of women. Sexual desire, arousal, and orgasm are three factors of female sexual response. So far many different methods has been known for the treatment of female sexual dysfunction, however none of them are not an efficacious therapy. Generally, use of herbal medicine is a safe and effective therapeutic method in the treatment of women with sexual dysfunction. The role of herbal and nutritional supplementation in female sexual function has attracted researchers’ interest in recent years. This study aimed to the evaluation of the studies focusing on the herbal medicine on women sexual function and the assessment of its effectiveness.

The Role of Physical Therapy in Sexual Health in Men and Women: Evaluation and Treatment

2019 ◽  
Vol 7 (1) ◽  
pp. 46-56 ◽  
Author(s):  
Amy Stein ◽  
Sara K. Sauder ◽  
Jessica Reale
Keyword(s):  
Physical Therapy ◽  
Sexual Health ◽  
Men And Women

scholarly journals Skin Immunology and Rejection in VCA and Organ Transplantation

2020 ◽  
Vol 7 (4) ◽  
pp. 251-259
Author(s):  
D. A. Leonard ◽  
K. R. Amin ◽  
H. Giele ◽  
J. E. Fildes ◽  
Jason K. F. Wong
Keyword(s):  
Animal Models ◽  
Lymph Nodes ◽  
Clinical Studies ◽  
Small Animal ◽  
Immune Protection ◽  
Small Animal Models ◽  
Skin Immunology ◽  
Discrete Populations

Abstract Purpose of Review Skin provides a window into the health of an individual. Using transplanted skin as a monitor can provide a powerful tool for surveillance of rejection in a transplant. The purpose of this review is to provide relevant background to the role of skin in vascularized transplantation medicine. Recent Findings Discrete populations of T memory cells provide distributed immune protection in skin, and cycle between skin, lymph nodes, and blood. Skin-resident TREG cells proliferate in response to inflammation and contribute to long-term VCA survival in small animal models. Early clinical studies show sentinel flap rejection to correlate well with facial VCA skin rejection, and abdominal wall rejection demonstrates concordance with visceral rejection, but further studies are required. Summary This review focuses on the immunology of skin, skin rejection in vascularized composite allografts, and the recent advances in monitoring the health of transplanted tissues using distant “sentinel” flaps.

scholarly journals Effect of the Nurse-Led Sexual Health Discharge Program on the Sexual Function of Older Patients Undergoing Transurethral Resection of Prostate: A Randomized Controlled Trial

Geriatrics ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 13
Author(s):  
Ramin Bayat ◽  
Hooman Shahsavari ◽  
Soghrat Faghihzadeh ◽  
Sara Amaniyan ◽  
Mojtaba Vaismoradi
Keyword(s):  
Sexual Health ◽  
Sexual Function ◽  
Sexual Desire ◽  
Transurethral Resection ◽  
Erectile Function ◽  
Older Patients ◽  
Intervention Group ◽  
Well Being ◽  
Transurethral Resection Of Prostate ◽  
Randomized Controlled

Background: Sexual dysfunction is a complication of transurethral resection of prostate (TURP). There is a lack of knowledge of the effect of discharge programs aiming at improving sexual function in older patients undergoing TURP. Objective: To investigate the effect of the nurse-led sexual health discharge program on the sexual function of older patients undergoing TURP. Methods: This randomized controlled clinical trial was conducted on 80 older patients undergoing TURP in an urban area of Iran. Samples were selected using a convenience method and were randomly assigned into intervention and control groups (n = 40 in each group). The sexual health discharge program was conducted by a nurse in three sessions of 30–45 min for the intervention group. Sexual function scores were measured using the International Index of Erectile Function (IIEF) Questionnaire, one and three months after the intervention. Results: The intervention significantly improved erectile function (p = 0.044), sexual desire (p = 0.01), satisfaction with sexual intercourse (p = 0.03), overall satisfaction with sexual function (p = 0.01), and the general score of sexual function (p = 0.038), three months after the program. In the first month after the intervention, except in sexual desire (p = 0.028), no statistically significant effect of the program was reported (p > 0.05). Conclusion: The nurse-led sexual health discharge program led to the improvement of the sexual function of older patients undergoing TURP over time. This program can be incorporated into routine discharge programs for the promotion of well-being in older patients.

scholarly journals Association of Sexual Attitudes with Sexual Function: General vs. Specific Attitudes

2021 ◽  
Vol 18 (19) ◽  
pp. 10390
Author(s):  
Juan Carlos Sierra ◽  
Jennifer Gómez-Carranza ◽  
Ana Álvarez-Muelas ◽  
Oscar Cervilla
Keyword(s):  
Sexual Health ◽  
Sexual Function ◽  
Sexual Desire ◽  
Sexual Functioning ◽  
Positive Attitude ◽  
Sexual Attitudes ◽  
Explanatory Models ◽  
Sexual Fantasies ◽  
Positive Attitudes ◽  
Diverse Pattern

Background: Sexual attitudes are related to the expression of sexuality and have been associated with indicators for sexual health. The main aim of this study was to determine the explanatory capacity of general (i.e., erotophilia) and specific (i.e., toward sexual fantasies and masturbation) sexual attitudes on different sexual functioning dimensions (sexual desire, sexual arousal, lubrication/erection, ability to have an orgasm and orgasm satisfaction). Methods: The sample consisted of 2000 heterosexual adults (1044 women, 956 men) aged 18–83 years. Results: The explanatory models for women mainly showed that positive attitudes toward sexual fantasies (β range = −0.35, −0.249) and age (β range = −0.111, 0.086) explained sexual function. The models proposed for men revealed a more diverse pattern, although the variable essential for explaining sexual function was a positive attitude toward sexual fantasies (β range = −0.266, −0.097). Conclusions: These results indicate that specific sexual attitudes, particularly in relation to sexual fantasies, are more sensitive variables than erotophilia in examining sexual health.

scholarly journals Latent class analysis of sexual health markers among men and women participating in a British probability sample survey

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Alison Parkes ◽  
Michael Waltenberger ◽  
Catherine Mercer ◽  
Anne Johnson ◽  
Kaye Wellings ◽  
...  
Keyword(s):  
General Population ◽  
Sexual Health ◽  
Sexual Function ◽  
Latent Class Analysis ◽  
Hiv Risk ◽  
Latent Class ◽  
Men And Women ◽  
Demographic Profiles ◽  
Risk Takers ◽  
Functional Problems

Abstract Background Despite known associations between different aspects of sexual health, it is not clear how patterning of adverse sexual health varies across the general population. A better understanding should contribute towards more effective problem identification, prevention and treatment. We sought to identify different clusters of sexual health markers in a general population, along with their socio-demographic, health and lifestyle correlates. Methods Data came from men (N = 5113) and women (N = 7019) aged 16–74 who reported partnered sexual activity in the past year in Britain’s third National Survey of Sexual Attitudes and Lifestyles, undertaken in 2010–2012. Latent class analysis used 18 self-reported variables relating to adverse sexual health outcomes (STI and unplanned pregnancy, non-volitional sex, and sexual function problems). Correlates included socio-demographics, early debut, alcohol/drug use, depression, and satisfaction/distress with sex life. Results Four classes were found for men (labelled Good Sexual Health 83%, Wary Risk-takers 4%, Unwary Risk-takers 4%, Sexual Function Problems 9%); six for women (Good Sexual Health 52%, Wary Risk-takers 2%, Unwary Risk-takers 7%, Low Interest 29%, Sexual Function Problems 7%, Highly Vulnerable 2%). Regardless of gender, Unwary Risk-takers reported lower STI/HIV risk perception and more condomless sex than Wary Risk-takers, but both were more likely to report STI diagnosis than Good Sexual Health classes. Highly Vulnerable women reported abortion, STIs and functional problems, and more sexual coercion than other women. Distinct socio-demographic profiles differentiated higher-risk classes from Good Sexual Health classes, with depression, alcohol/drug use, and early sexual debut widely-shared correlates of higher-risk classes. Females in higher-risk classes, and men with functional problems, evaluated their sex lives more negatively than those with Good Sexual Health. Conclusions A greater prevalence and diversity of poor sexual health appears to exist among women than men in Britain, with more consistent effects on women’s subjective sexual well-being. Shared health and lifestyle characteristics of higher-risk groups suggest widespread benefits of upstream interventions. Several groups could benefit from tailored interventions: men and women who underestimate their STI/HIV risk exposure, women distressed by low interest in sex, and women experiencing multiple adverse outcomes. Distinctive socio-demographic profiles should assist with identification and targeting.

scholarly journals Alteration of Endothelins: A Common Pathogenetic Mechanism in Chronic Diabetic Complications

2002 ◽  
Vol 3 (4) ◽  
pp. 217-231 ◽  
Author(s):  
Subrata Chakrabarti ◽  
Zia Ali Khan ◽  
Mark Cukiernik ◽  
Gen Fukuda ◽  
Shali Chen ◽  
...  
Keyword(s):  
Animal Models ◽  
Diabetic Complications ◽  
Clinical Studies ◽  
Vascular Function ◽  
Potential Role ◽  
Pathogenetic Mechanism ◽  
Functional Changes

Endothelin (ET) peptides perform several physiological, vascular, and nonvascular functions and are widely distributed in a number of tissues. They are altered in several disease processes including diabetes. Alteration of ETs have been demonstrated in organs of chronic diabetic complications in both experimental and clinical studies. The majority of the effects of ET alteration in diabetes are due to altered vascular function. Furthermore, ET antagonists have been shown to prevent structural and functional changes induced by diabetes in animal models. This review discusses the contribution of ETs in the pathogenesis and the potential role of ET antagonism in the treatment of chronic diabetic complications.

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