scholarly journals Editorial. Prevention of Hepatocellular Carcinoma

2012 ◽  
Vol 1 (1) ◽  
pp. 7-13
Author(s):  
Ryota Masuzaki ◽  
Masao Omata
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Development ◽  
Tumor Stage ◽  
Curative Treatment ◽  
Percutaneous Ablation ◽  
Hepatitis Viruses ◽  
Liver Disease Progression ◽  
Long Term Prognosis ◽  
Related Mortality

Abstract Hepatocellular carcinoma (HCC) is the fifth common cancer in the world, showing the third highest cancer related mortality. The prognosis of HCC patients depends not only on tumor stage but also on the background liver function reservoir. Effective treatments for HCC include percutaneous ablation, surgical resection and liver transplantation. Although short-term prognosis of HCC patients has been much improved recently due to advances in early diagnosis and treatment, long-term prognosis is as yet far from satisfactory as indicated by the overall survival at 10 years after apparently curative treatment of only 22%-35%. Primary prevention aims to evade the tumor development with health measures that prevent people from exposure to known risk factors like hepatitis viruses or alcohol, or attenuating liver disease progression to HCC. While secondary prevention aims to diagnose HCC at an early, potentially curable stage, tertiary prevention aims to reduce the risk of HCC recurrence after curative treatment. In this article we focus on prevention of HCC and the new advance in this field.

scholarly journals Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
De-Chen Yu ◽  
Xiang-Yi Chen ◽  
Xin Li ◽  
Hai-Yu Zhou ◽  
De-Quan Yu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protein Complex ◽  
Immune Cell ◽  
Prognostic Significance ◽  
Tumor Development ◽  
Disease Free Survival ◽  
Tumor Grade ◽  
Tumor Stage ◽  
Prognostic Biomarkers ◽  
High Expression

AbstractThe spindle and kinetochore-associated protein complex (Ska) is an essential component in chromosome segregation. It comprises three proteins (Ska1, Ska2, and Ska3) with theorized roles in chromosomal instability and tumor development, and its overexpression has been widely reported in a variety of tumors. However, the prognostic significance and immune infiltration of Ska proteins in hepatocellular carcinoma (HCC) are not completely understood. The bioinformatics tools Oncomine, UALCAN, gene expression profiling interactive analysis 2 (GEPIA2), cBioPortal, GeneMANIA, Metascape, and TIMER were used to analyze differential expression, prognostic value, genetic alteration, and immune cell infiltration of the Ska protein complex in HCC patients. We found that the mRNA expression of the Ska complex was markedly upregulated in HCC. High expression of the Ska complex is closely correlated with tumor stage, patient race, tumor grade, and TP53 mutation status. In addition, high expression of the Ska complex was significantly correlated with poor disease-free survival, while the high expression levels of Ska1 and Ska3 were associated with shorter overall survival. The biological functions of the Ska complex in HCC primarily involve the amplification of signals from kinetochores, the mitotic spindle, and (via a MAD2 invasive signal) unattached kinetochores. Furthermore, the expression of the complex was positively correlated with tumor-infiltrating cells. These results may provide new insights into the development of immunotherapeutic targets and prognostic biomarkers for HCC.

Sorafenib for Hepatocellular Carcinoma: From Randomized Controlled Trials to Clinical Practice

2015 ◽  
Vol 33 (5) ◽  
pp. 668-674 ◽  
Author(s):  
Giuseppe Cabibbo ◽  
Salvatore Petta ◽  
Marcello Maida ◽  
Calogero Cammà
Keyword(s):  
Hepatocellular Carcinoma ◽  
Randomized Controlled Trials ◽  
Growth Factor Receptor ◽  
Standard Of Care ◽  
Tumor Stage ◽  
Percutaneous Ablation ◽  
Controlled Trials ◽  
Solid Malignancy ◽  
Raf Kinase ◽  
Randomized Controlled

Hepatocellular carcinoma is a challenging malignancy of global importance. It is the sixth most common solid malignancy and the third leading cause of cancer-related death, worldwide. Curative treatments at early stages include liver transplantation, resection and percutaneous ablation, while transarterial chemoembolization can improve survival in patients with intermediate tumor stage. Patients with mild, related symptoms and/or macrovascular invasion or extrahepatic spread are classified under the advanced stage. The standard of care in this group is sorafenib, an inhibitor of Raf kinase and vascular endothelial growth factor receptor, whose effectiveness has been proven by 2 recent randomized controlled trials (RCTs). The aim of this brief review is to highlight the main concerns and pitfalls and to analyze the recent data of literature regarding the efficacy and the management of sorafenib therapy from RCTs to real practice.

scholarly journals Recompensation of Decompensated Hepatitis B Cirrhosis: Current Status and Challenges

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Hong Zhao ◽  
Qi Wang ◽  
Changling Luo ◽  
Ligai Liu ◽  
Wen Xie
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Antiviral Treatment ◽  
Research Data ◽  
Current Status ◽  
Evaluation Time ◽  
Long Term Prognosis ◽  
Time Evaluation

Liver-function decompensation or hepatocellular carcinoma (HCC) gradually appears after chronic hepatitis B progresses to cirrhosis. Effective antiviral treatment can significantly improve the long-term prognosis of decompensated patients, and some patients present recompensation of decompensated hepatitis B cirrhosis. At present, there are limited research data on the recompensation of decompensated hepatitis B cirrhosis. There is still controversy regarding the evaluation time, evaluation indicators, influencing factors, and long-term prognosis of recompensation.

Long-Term Outcome of Percutaneous Ablation in Very Early-Stage Hepatocellular Carcinoma

2011 ◽  
Vol 15 (12) ◽  
pp. 2165-2171 ◽  
Author(s):  
Ming Kuang ◽  
Xiao-Yan Xie ◽  
Cheng Huang ◽  
Ye Wang ◽  
Man-Xia Lin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Early Stage ◽  
Percutaneous Ablation ◽  
Term Outcome ◽  
Long Term Outcome
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