scholarly journals Bile leakage after liver transplantation

Open Medicine ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 424-429 ◽  
Author(s):  
Cheng Fang ◽  
Sheng Yan ◽  
Shusen Zheng
Keyword(s):  
Liver Transplantation ◽  
Survival Rate ◽  
Patient Survival ◽  
Survival Rates ◽  
Operating Time ◽  
Bile Leak ◽  
Deceased Donor ◽  
Donor Liver Transplantation ◽  
One Year ◽  
Patient Survival Rate

AbstractObjective To evaluate the risk factors and outcome of bile leak after liver transplantation.MethodsWe undertook a retrospective study of patients who underwent liver transplantation in our institution between January 2010 and January 2014. The characteristics and survival rate of patients with or without bile leak were compared.ResultsBile leak was observed in sixteen patients after liver transplantation (2.7% of the total number of patients transplanted). Total operating time and bile duct reconstruction technique (duct-to-duct anastomosis or Rouxen-Y cholangiojejunostomy) were found to differ significantly between patients with and without bile leak in univariate (p = 0.001 and 0.024, respectively) and multivariate analyses (p = 0.012 and 0.026, respectively). There was no difference in the one-year patient survival rate between the two groups. However, two-year patient survival rate was significantly lower in the bile leak group (p = 0.003). Both one-year and two-year graft survival rates were significantly lower in the bile leak group (p = 0.049 and <0.001, respectively).ConclusionsCholangiojejunostomy and prolonged total operating time are risk factors for bile leak after deceased donor liver transplantation. Bile leak reduces graft and patient survival rates after deceased donor liver transplantation.

scholarly journals The long-term outcomes of deceased-donor liver transplantation for primary biliary cirrhosis: a two-center study in China

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9563
Author(s):  
Lin Chen ◽  
Xiaodong Shi ◽  
Guoyue Lv ◽  
Xiaodong Sun ◽  
Chao Sun ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Survival Rate ◽  
Primary Biliary Cirrhosis ◽  
Liver Function ◽  
Deceased Donor ◽  
Biliary Cirrhosis ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Deceased Donor Liver Transplantation

Background & Aims Factors that influence the outcomes after deceased-donor liver transplantation (DDLT) for primary biliary cirrhosis (PBC) are not well known. We aimed to clarify these effects on the outcomes after DDLT. Methods We retrospectively analyzed patients with PBC who underwent DDLT from March 2006 to July 2018 at the organ transplantation center of the First Hospital of Jilin University and the First Central Hospital of Tianjin. Changes in liver function were assessed posttransplantation. Recurrence, survival rate, and complications were recorded at follow-up. The effect of liver transplantation on survival and recurrence was evaluated using univariate and/or multivariate Cox regression analyses. Results In total, 69 patients with PBC undergoing DDLT were included in this study. At 4 weeks posttransplant, all liver function tests were normal. During a median follow-up time of 32 months, 5-year overall survival and recurrence rates were estimated as 95.1% and 21.8%, respectively. A recipient aspartate aminotransferase-to-platelet ratio index (APRI) greater than 2 was negatively associated with survival (P = 0.0018). Multivariate regression analysis demonstrated that age younger than 48 years was an independent risk factor for recurrent PBC in recipients undergoing liver transplantation (hazard ratio 0.028, 95% confidence interval 0.01–0.71, P = 0.03). Posttransplant infections (62%) and biliary tract complications (26%) were the most common complications. Conclusion Liver transplantation is an effective treatment for patients with PBC. Liver function normalizes by 4 weeks posttransplant. Although posttransplant survival rate is high, recurrence is possible. To some extent, survival rate and recurrence rate can be predicted by APRI and age, respectively.

scholarly journals Survival and Complication of Liver Transplantation in Infants: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 9 ◽  
Author(s):  
Yifu Hou ◽  
Xiaoxiao Wang ◽  
Hongji Yang ◽  
Shan Zhong
Keyword(s):  
Liver Transplantation ◽  
Survival Rate ◽  
Graft Survival ◽  
Patient Survival ◽  
Meta Analysis ◽  
Survival Rates ◽  
Surgical Techniques ◽  
Vascular Complications ◽  
Complication Rates ◽  
Post Transplantation

Background: Modern surgical techniques and scientific advancements have made liver transplant (LT) in infants feasible. However, there are only a small number of studies examining the short- as well as long-term outcomes of LT in this vulnerable subset of children.Methods: Comprehensive searches were done systematically through the PubMed, Scopus, and Google scholar databases. Studies that were retrospective record based or adopted a cohort approach and reported either patient survival rates or graft survival rates or complications of LT in infants were included in the meta-analysis. Statistical analysis was done using STATA version 13.0.Results: A total of 22 studies were included in the meta-analysis. The overall pooled patient survival rate at 1 year, &gt;1–5 years, and &gt;5 years post-transplantation was 85% (95% CI: 78-−92%), 71% (95% CI: 59–83%), and 80% (95% CI: 69–91%), respectively. The overall pooled graft survival rate at 1 year, &gt;1–5 years, and &gt;5 years post-transplantation was 72% (95% CI: 68–76%), 62% (95% CI: 46–78%), and 71% (95% CI: 56–86%), respectively. The overall pooled rate for vascular complications, need for re-transplantation, biliary complications, and infection/sepsis was 12% (95% CI: 10–15%), 16% (95% CI: 12–20%), 15% (95% CI: 9–21%), and 50% (95% CI: 38–61%), respectively.Conclusion: The current meta-analysis showed modest patient and graft survival rates for infant liver transplantation. However, the complication rates related to infection/sepsis were high. More comprehensive evidence is required from studies with larger sample sizes and a longer duration of follow-up.

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