Cow milk and its dairy products ameliorate bone toxicity in the Coragen-induced rat model

Abstract Coragen is an insecticide that stimulates calcium release from intracellular stores of muscle cells causing death to sensitive species. The present study aimed to evaluate the bone toxic effect of Coragen and the potential therapeutic effect of cow milk, yogurt, and soft cheese in rats. Toxicity was induced by Coragen administration with different doses of 1/20 or 1/40 LD50 in rats. Groups of rats (n = 6) were treated with either 5 g milk, 5 g yogurt, or 1.5 g cheese. Coragen administration elevated alkaline and acid phosphatases activity and reduced the calcium and phosphorus level in urine and serum of rats administered with Coragen. Femur and tibia length, thickness, weight, and breaking force were decreased by Coragen administration and femur Ca and P contents as well. Bone mineral area (BMA), bone mineral content (BMC), bone mineral density (BMD), protein profile (total, albumin, and globulin), and antioxidant system (TAC, GSH, GPX, GST, and SOD) were decreased by Coragen. All these parameters were improved on the treatment with milk and milk products. The results showed that yogurt treatment was significantly superior to the other treatments in increasing BMD (27%), breaking force (9%), femur Ca (41%), serum Ca (14%), and serum P (16%) and in reducing acid phosphatases (14%) and urine Ca and P by 8 and 10%, respectively. It can be concluded that the treatment with milk and milk products may provide treatment against osteoporosis and toxicity caused by Coragen.

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Interrelations of the Calcium Concentration in Breast Milk with Maternal Intake of Cow's Milk and Milk Products, Bone Resorption and Bone Mineral Density during Lactation.

Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) ◽

10.1265/jjh.51.770 ◽

1997 ◽

Vol 51 (4) ◽

pp. 770-779 ◽

Cited By ~ 2

Author(s):

Kyoko YONEYAMA ◽

Junko IKEDA ◽

Hisanori NAGATA

Keyword(s):

Bone Mineral Density ◽

Breast Milk ◽

Bone Resorption ◽

Bone Mineral ◽

Calcium Concentration ◽

Cow’S Milk ◽

Mineral Density ◽

Milk Products ◽

Cow's Milk

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Effect of milk and milk products consumption on physical growth and bone mineral density in Korean adolescents

Nutrition Research and Practice ◽

10.4162/nrp.2013.7.4.309 ◽

2013 ◽

Vol 7 (4) ◽

pp. 309 ◽

Cited By ~ 12

Author(s):

Sun Hyo Kim ◽

Woo Kyoung Kim ◽

Myung-Hee Kang

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Physical Growth ◽

Mineral Density ◽

Milk Products ◽

Korean Adolescents

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Bone mineral density and computer tomographic measurements in correlation with failure strength of equine metacarpal bones

Acta Veterinaria Brno ◽

10.2754/avb201483010045 ◽

2014 ◽

Vol 83 (1) ◽

pp. 45-50 ◽

Cited By ~ 2

Author(s):

Péter Tóth ◽

Grace Hinton ◽

Csaba Horváth ◽

Viktória Ferencz ◽

Balázs Tóth ◽

...

Keyword(s):

Mechanical Properties ◽

Bone Mineral Density ◽

Bone Mineral ◽

Region Of Interest ◽

Metacarpal Bone ◽

Breaking Force ◽

Mineral Density ◽

Cross Sectional ◽

Computer Tomographic ◽

Metacarpal Bones

Information regarding bone mineral density and fracture characteristics of the equine metacarpus are lacking. The aim of this study was to characterize the relationship between mechanical properties of the equine metacarpal bone and its biomechanical and morphometric properties. Third metacarpal bones were extracted from horses euthanized unrelated to musculoskeletal conditions. In total, bone specimens from 26 front limbs of 13 horses (7.8 ± 5.8 years old) including Lipizzaner (n = 5), Hungarian Warmblood (n = 2), Holsteiner (n = 2), Thoroughbred (n = 1), Hungarian Sporthorse (n = 1), Friesian (n = 1), and Shagya Arabian (n = 1) were collected. The horses included 7 mares, 4 stallions and 2 geldings. Assessment of the bone mineral density of the whole bone across four specific regions of interest was performed using dual-energy X-ray absorptiometry. The bones were scanned using a computer tomographic scanner to measure cross-sectional morphometric properties such as bone mineral density and cross-sectional dimensions including cortical area and cortical width. Mechanical properties (breaking force, bending strength, elastic modulus) were determined by a 3-point bending test. Significant positive linear correlations were found between the breaking force and bone mineral density of the entire third metacarpal bones (P < 0.001, r = 0.72), the medial cortex region of interest (P < 0.001, r = 0.68) and the transverse region of interest (P < 0.001, r = 0.61). The correlation between the breaking force and bone mineral density of the equine third metacarpal bone found in this study warrants in vivo investigations.

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