scholarly journals Serum Neopterin Levels and IDO Activity as Possible Markers for Presence and Progression of Hepatitis B

Pteridines ◽  
2020 ◽  
Vol 31 (1) ◽  
pp. 91-99
Author(s):  
Deniz Öğütmen Koç ◽  
Yağmur Özhan ◽  
Ebru Türköz Acar ◽  
Nilgün Bireroğlu ◽  
Fatih Aslan ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Activity Index ◽  
Strong Positive Correlation ◽  
Mortality And Morbidity ◽  
Serum Neopterin ◽  
Tryptophan Degradation ◽  
Immune System Activation ◽  
Study Results ◽  
Chronic Hepatitis B Virus ◽  
Histological Activity

AbstractChronic Hepatitis B virus (HBV) is still one of the major reasons for liver related mortality and morbidity all around the world. This study aimed to investigate the possible relationship between the immune system activation and presence, as well as progression, of hepatitis B infection by monitoring the tryptophan degradation and serum neopterin levels in patients with HBV. 110 patients with HBV and 23 healthy subjects were included in the study. The patients had significantly higher neopterin levels and increased kynurenine to tryptophan ratios, which were most probably due to enhanced indoleamine 2,3-dioxygenase (IDO) activity compared to healthy control. A strong positive correlation was found between neopterin levels and IDO activity in patient group. Neopterin levels and IDO activity were markedly increased in patients with histological activity index (HAI) ≥4 compared to HAI<4, and a significant correlation was found between neopterin and HAI. Moreover, there was a significant correlation between albumin levels and IDO activity in HBV patients. These findings suggest that tryptophan degradation results from IFN-γ-induced IDO activation, likewise depletion of albumin synthesis in HBV patients may result from diminished tryptophan availability. In conclusion, based on the study results, serum neopterin levels and IDO activity could provide additional immunological information for monitoring liver histological activity and can be used as prognostic markers in HBV disease.

scholarly journals Potential Prognostic Role of Immune System Activation Marker Neopterin in Patients with Type 2 Diabetes

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Songül Ünüvar ◽  
Zübeyde Tanrıverdi ◽  
Hamza Aslanhan
Keyword(s):  
Type 2 Diabetes ◽  
Bacterial Infections ◽  
Metabolic Diseases ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Serum Neopterin ◽  
Immune System Activation ◽  
Study Results

Summary Background: An increase in neopterin concentrations is known in some pathologies due to interferon-gamma (INF-γ) activation. These include viral and bacterial infections, auto immune diseases, metabolic diseases, psychiatric disorders, tissue and organ rejections, and different malignancies. The aim of this study was to evaluate the role of neopterin as a prognostic biomarker in type 2 diabetes, which is a metabolic disease with a high worldwide prevalence. Methods: The study included a total of one hundred thirty-nine individuals including one hundred and six patients admitted to a family medicine outpatient clinic and diagnosed with type 2 diabetes and thirty-three healthy volunteers. Serum neopterin concentrations were measured using the enzyme-linked immunosorbent assay. Results: Serum neopterin levels significantly increased in type 2 diabetes patients, compared to the control group (p<0.00001). Conclusions: Early diagnosis of diabetes and determination of the appropriate therapeutic options are of utmost importance, as diabetes is also associated with other systemic diseases. The risk of developing secondary diseases is high in untreated patients. Our study results suggest that serum neopterin may be a useful biomarker in patients with type 2 diabetes.

scholarly journals Analysis of Serum MicroRNA-122 Expression at Different Stages of Chronic Hepatitis B Virus Infection

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Wenjun Liu ◽  
Fei Huang ◽  
Xinxiang He
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Liver Injury ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Activity Index ◽  
Early Stage ◽  
Hbv Dna ◽  
Chronic Hepatitis B Virus ◽  
B Virus

Objective. To investigate the expression of microRNA-122 (miR-122) in the progression of chronic hepatitis B virus- (HBV-) infected liver diseases, thus determining the role of serum miR-122 as a marker of HBV-caused liver injury. Methods. Sera were collected from patients with different stages of HBV infection ( n = 63 ) and healthy volunteers ( n = 11 ). And the serum miR-122 levels were detected using RT-qPCR. Moreover, an analysis was applied for identifying the specific correlation of the miR-122 level with HBV DNA, HBeAg, and ALT levels. After liver biopsy, Ishak scoring was utilized for evaluation of the fibrosis stage and the histological activity index (HAI). Results. We confirmed, in the serum, increased miR-122 expression in HBV-infected patients and its highest expression in chronic HBV carriers, based on such comparison between the healthy controls and patients. The correlation analysis results were taken as confirmation of the positive relationship of miR-122 with HBV DNA ( r = 0.354 , P = 0.005 ) and ALT ( r = 0.331 , P = 0.009 ). But no correlation of this molecule with HBeAg levels was found ( P = 0.187 ). In comparison with the HBeAg-negative patients, serum miR-122 expression showed an increase in the HBeAg-positive patients ( P = 0.001 ). miR-122 expression, in addition, was of a significant correlation with HAI, but not with the liver fibrosis score. Conclusion. The peak of the serum miR-122 expression normally occurs in the early stage of the progression from the HBV carrier phase to chronic hepatitis to cirrhosis. This molecule can be considered as a marker for evaluation of HBV-caused liver injury.

scholarly journals Potential Prognostic Role of Immune System Activation Marker Neopterin in Patients with Type 2 Diabetes

2018 ◽  
Vol 37 (4) ◽  
pp. 465-469 ◽  
Author(s):  
Songül Ünüvar ◽  
Zübeyde Tanrıverdi ◽  
Hamza Aslanhan
Keyword(s):  
Type 2 Diabetes ◽  
Bacterial Infections ◽  
Metabolic Diseases ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Serum Neopterin ◽  
Immune System Activation ◽  
Study Results

Summary Background: An increase in neopterin concentrations is known in some pathologies due to interferon-gamma (INF-γ) activation. These include viral and bacterial infections, auto immune diseases, metabolic diseases, psychiatric disorders, tissue and organ rejections, and different malignancies. The aim of this study was to evaluate the role of neopterin as a prognostic biomarker in type 2 diabetes, which is a metabolic disease with a high worldwide prevalence. Methods: The study included a total of one hundred thirtynine individuals including one hundred and six patients admitted to a family medicine outpatient clinic and diagnosed with type 2 diabetes and thirty-three healthy volunteers. Serum neopterin concentrations were measured using the enzyme-linked immunosorbent assay. Results: Serum neopterin levels significantly increased in type 2 diabetes patients, compared to the control group (p<0.001). Conclusions: Early diagnosis of diabetes and determination of the appropriate therapeutic options are of utmost importance, as diabetes is also associated with other systemic diseases. The risk of developing secondary diseases is high in untreated patients. Our study results suggest that serum neopterin may be a useful biomarker in patients with type 2 diabetes.

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