Evaluation of radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT

Abstract Background. The aim of the study was to retrospectively evaluate radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT and determine their roles on the evaluation of therapy response. Patients and methods. We retrospectively evaluated radiographic and metabolic characteristics of bone metastases in 30 patients who were referred for the evaluation of response to systemic therapy with 18FDG-PET/CT. All patients underwent integrated 18FDG-PET/CT before and after treatment. Results. The baseline radiographic patterns of the target lesions in responders group were lytic, sclerotic, mixed and CT negative; after treatment the radiographic patterns of all target lesions changed to a sclerotic pattern and attenuation increased (p = 0.012) and metabolic activity decreased (p = 0.012). A correlation was found between decreasing metabolic activity and increasing attenuation of the target lesions (r = -0.55) (p = 0.026). Ho wever, in nonresponders group, the baseline radiologic patterns of the target lesions were lytic, blastic, mixed and CT negative; after treatment all lytic target lesions remained the same and one CT negative lesion turned to lytic pattern and the attenuation of the target lesions decreased (p ± 0.12) and metabolic activity increased (p = 0.012). A correlation was found between increasing metabolic activity and decreasing attenuation (r = -0.65) (p = 0.032). An exception of this rule was seen in baseline blastic metastases which progressed with increasing in size, metabolic activity and attenuation. Conclusions. This study shows that the metabolic activity of lesions is a more reliable parameter than the radiographic patterns for the evaluation of therapy response.

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The Pons As Region of Reference For Intensity Normalization In Semi-Quantitative Analysis of Brain 18FDG PET: Application to Metabolic Changes Related to Ageing in Conventional and Digital Control Databases

10.21203/rs.3.rs-152698/v1 ◽

2021 ◽

Author(s):

Antoine Verger ◽

Matthieu Doyen ◽

Jacques-Yves Campion ◽

Eric Guedj

Keyword(s):

Fdg Pet ◽

Correlation Coefficients ◽

Metabolic Changes ◽

18Fdg Pet ◽

Median Correlation ◽

Pet Ct ◽

Digital Pet ◽

Fdg Pet Ct ◽

Intensity Normalization ◽

Two Populations

Abstract Background: To define the most appropriate region for intensity normalization in brain 18FDG PET analysis through ageing.Brain metabolic changes related to ageing were evaluated in two populations of healthy controls who underwent conventional (n=56) or digital (n=78) 18FDG PET/CT. The median correlation coefficients between age and the metabolism of each 120 atlas brain region were reported for 120 distinct intensity normalizations (according to the 120 regions). SPM linear regression analyses with age were performed on most significant normalizations (FWE, p<0.05).Results: The cerebellum and pons were the two sole regions showing median coefficients of correlation with age less than -0.5. With SPM, the intensity normalization through the pons provided at least 1.7- and 2.5-fold more significant cluster volumes than other normalizations for conventional and digital PET respectively. Conclusions: The pons is the most appropriate area for brain 18FDG PET intensity normalization for examining the metabolic changes through ageing.

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Role of PET-CT in Aiding Diagnosis of Various Neurological Conditions – A Case Series

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2021/97 ◽

2021 ◽

Vol 10 (7) ◽

pp. 440-446

Author(s):

Harleen Singh Pabla ◽

Gokulakrishnan P.R. ◽

Arunan Murali ◽

Venkata Sai P.M.

Keyword(s):

Metabolic Activity ◽

Fdg Pet ◽

Caudate Nuclei ◽

Fdg Uptake ◽

18Fdg Pet ◽

Pet Ct ◽

Neurological Conditions ◽

Fdg Pet Ct ◽

The Brain

BACKGROUND PET-CT is an imaging modality which electronically detects positron-emitting radiopharmaceuticals in the human body and reveals its exact anatomical location.1 PET CT measures the metabolic and functional activity of living tissue noninvasively.1 This technology is utilized in diagnosis, planning treatment and predicting outcomes in various neurological conditions.1 Depending upon various patterns of FDG uptake in different parts of brain, 18FDG PET-CT allows us to differentiate between various types of dementia.2 PET CT allows tracking the course of disease and revealing the severity of the disease.2 In this article, we discuss the imaging findings of normal 18 FDG PET-CT of brain and 8 different neurological conditions with their corresponding brain PET-CT findings. METHODS To study the role of 18FDG-PET/CT in neurological conditions, we identified 8 different patients who underwent 18FDG-PET/CT imaging of brain for clinically suspected different neurological diseases at Department of Radiodiagnosis-Centre of Excellence (CERIS), SRIHER, Chennai, between 2015 and 2019. Siemens Biograph Horizon 16-slice PET/CT scanner with TrueV was used. Syngo.Via Version VB30A software was used. 18F- Fluorodeoxyglucose was the radiotracer used [Dose: 3-7 mCi]. After the scan, different patterns of 18 FDG uptake in the brain were analyzed in each of these patients. RESULTS 18 FDG PET-CT showed reduced uptake in the epileptogenic foci in the brain. Alzheimer’s disease showed decreased FDG uptake in bilateral precuneus, posterior cingulate region, parietal cortex and frontal cortex. Fronto-temporal dementia revealed reduced FDG uptake in anterior cingulate gyrus and anterior temporal lobe. Primary progressive aphasia showed asymmetrical reduced metabolic activity in the bilateral frontal and temporal lobes. Progressive supranuclear palsy revealed reduced metabolic activity in bilateral paramedian frontal region, head of caudate nuclei and midbrain; Multi systemic atrophy showed reduced metabolic activity in midbrain, pons, medulla oblongata and the cerebellum; AIDS related dementia showed global hypometabolism with preserved uptake in basal ganglia. CONCLUSIONS 18FDG-PET/CT has a vital complementary role in the evaluation CNS disorders along with clinical examination, other imaging modalities like CT, MRI, and electroencephalogram (EEG). Radiologists should be aware of these different patterns of FDG uptake to aid the clinical diagnosis and early treatment. KEY WORDS 18 FDG PET-CT, 18FDG Uptake, Hypometabolism, PET-CT Brain

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Cortico-Subcortical Metabolic Changes in Aging Brain: A 18F FDG PET/CT Study

International Journal of Nuclear Medicine Research ◽

10.15379/2408-9788.2014.01.01.4 ◽

2014 ◽

Vol 1 (1) ◽

pp. 17-23 ◽

Cited By ~ 1

Author(s):

Agostino Chiaravalloti ◽

◽

Paolo Abbatiello ◽

Ferdinando Calabria ◽

Barbara Palumbo ◽

...

Keyword(s):

Fdg Pet ◽

Metabolic Changes ◽

Aging Brain ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Hybrid Imaging in Evaluation of Abdominal Sarcoidosis

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405614666180531111616 ◽

2018 ◽

Vol 15 (1) ◽

pp. 26-31 ◽

Cited By ~ 1

Author(s):

Isidora Grozdic Milojevic ◽

Dragana Sobic-Saranovic ◽

Nebojsa Petrovic ◽

Slobodanka Beatovic ◽

Marijana Tadic ◽

...

Keyword(s):

Fdg Pet ◽

Therapy Response ◽

Ct Examination ◽

Abdominal Disease ◽

Pet Ct ◽

Fdg Pet Ct ◽

Total Remission ◽

Active Disease

Objective: To determine the prevalence of abdominal involvement, distribution pattern and evaluate role of hybrid molecular imaging in patients with abdominal sarcoidosis. Methods: Between January 2010 and December 2011, 98 patients with chronic sarcoidosis and presence of prolonged symptoms or other findings suggestive of active disease were referred to FDG PET/CT examination. Active disease was found in 82 patients, and they all were screened for the presence of abdominal sarcoidosis on FDG PET/CT. All patients also underwent MDCT and assessment of serum ACE level. Follow up FDG PET/CT examination was done 12.3±5.4 months after the baseline. Results: Abdominal sarcoidosis was present in 31/82 patients with active sarcoidosis. FDG uptake was present in: retroperitoneal lymph nodes (77%), liver (26%), spleen (23%), adrenal gland (3%). Majority of patients had more than two locations of disease. Usually thoracic disease was spread into the extrathoracic localizations, while isolated abdominal sarcoidosis was present in 10% of patients. After first FDG PET/CT examination therapy was changed in all patients. Eleven patients came to the follow up examination where SUVmax significantly decreased in the majority of them. Three patients had total remission, three had absence of abdominal disease but discrete findings in thorax and others had less spread disease. ACE levels did not correlate with SUVmax level. Conclusion: FDG PET/CT can be a useful tool for detection of abdominal sarcoidosis and in the evaluation of therapy response in these patients. Awareness of the presence of intra-abdominal sarcoidosis is important in order to prevent long-standing unrecognized disease.

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323P The role of SUVmax in 18F-FDG PET/CT for assessing radiation therapy response for cervical cancer

Annals of Oncology ◽

10.1093/annonc/mdw585.027 ◽

2016 ◽

Vol 27 (suppl_9) ◽

Author(s):

S.H. Lee ◽

K.C. Lee ◽

K. Sung ◽

E.Y. Choi ◽

J.B. Bae ◽

...

Keyword(s):

Cervical Cancer ◽

Radiation Therapy ◽

Fdg Pet ◽

Therapy Response ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Metabolic activity of visceral fat and immune-related organs evaluated by 18F-FDG PET/CT is associated with the metabolic syndrome

European Heart Journal ◽

10.1093/ehjci/ehaa946.3051 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

K Pahk ◽

H.W Kwon ◽

J.S Eo ◽

H.S Seo ◽

S Kim

Keyword(s):

Metabolic Syndrome ◽

Systemic Inflammation ◽

Metabolic Activity ◽

Fdg Pet ◽

Inflammatory Activity ◽

The Metabolic Syndrome ◽

Inflammatory Status ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Abstract Background The risk of cardiovascular disease (CVD) is elevated in metabolic syndrome (MS) and is related to the inflammatory activity of visceral adipose tissue (VAT). We investigated whether the metabolic activity in VAT, assessed by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), is associated with systemic inflammatory status, and related to the number of MS components. Methods 18F-FDG PET/CT was performed in a total of 203 subjects: 59 without an MS component; M(0), 92 with one or two MS components; M(1–2), and 52 with MS. Metabolic activity of VAT was evaluated using the mean standardized uptake value (SUVmean) and the maximum SUV (SUVmax). Metabolic activities of immune-related organs such as spleen and bone marrow (BM) were evaluated using the SUVmax. Results VAT SUVmax correlated with high-sensitivity C-reactive protein (hsCRP) and the SUVmax of spleen and BM, which reflect the status of systemic inflammation. Both hsCRP and the SUVmax of the spleen and BM were higher in the MS group than in the M(1–2) or M(0) groups. In VAT, SUVmax increased with increasing number of MS components, while SUVmean decreased. Conclusions The SUVmax of VAT assessed by 18F-FDG PET/CT could reflect the inflammatory activity of VAT which is increased in the MS patients with systemic inflammation. Funding Acknowledgement Type of funding source: None

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