The Pons As Region of Reference For Intensity Normalization In Semi-Quantitative Analysis of Brain 18FDG PET: Application to Metabolic Changes Related to Ageing in Conventional and Digital Control Databases
Abstract Background: To define the most appropriate region for intensity normalization in brain 18FDG PET analysis through ageing.Brain metabolic changes related to ageing were evaluated in two populations of healthy controls who underwent conventional (n=56) or digital (n=78) 18FDG PET/CT. The median correlation coefficients between age and the metabolism of each 120 atlas brain region were reported for 120 distinct intensity normalizations (according to the 120 regions). SPM linear regression analyses with age were performed on most significant normalizations (FWE, p<0.05).Results: The cerebellum and pons were the two sole regions showing median coefficients of correlation with age less than -0.5. With SPM, the intensity normalization through the pons provided at least 1.7- and 2.5-fold more significant cluster volumes than other normalizations for conventional and digital PET respectively. Conclusions: The pons is the most appropriate area for brain 18FDG PET intensity normalization for examining the metabolic changes through ageing.