The article deals with the main integration associations of such a promising but controversial region, as Sub-Saharan Africa. The author emphasizes the continuity of regional integration associations’ formation that goes back to the colonial times, to the first half of the 20th century. Periodization of ongoing integration processes in Sub-Saharan Africa is proposed in the research. Key milestones for the further regional integration were: - 1963, the foundation of the Organisation of African Unity (OAU); and the beginning of Independence for many postcolonial countries of Sub-Saharan Africa; - 1980, the Lagos Plan of Action adoption that led to the establishment in future of the following integration associations for Sub-Saharan Africa: ECOWAS, Economic Community of West African States; COMESA, Common Market for Eastern and Southern Africa; ECCAS, Economic Community of Central African States; - 1991, the signing of the Abuja Treaty, which called for the African Economic Community creation as the new stage for economic cooperation and integration of the continent, including Sub-Saharan Africa; - 1999-2002, the Organisation of African Unity (OAU) transition into the African Union (AU), launching of new partnerships and integration associations for Sub-Saharan Africa, increased integration. At the beginning of the 21st century, there are serious economic and political factors for disintegration in the region. Nevertheless, the following integration associations, as stated in the article, proved to be effective: SADC, Southern African Development Community; EAC, East African Community; COMESA, Common Market for Eastern and Southern Africa. The author argues that the existence since 2015 the Tripartite Free Trade Area (TFTA) between EAC, COMESA and SADC marks a significant step forward for strengthening of integration associations for Sub-Saharan Africa, as well as for the achievement of African Union’s purpose to provide the African Continental Free Trade Area.