The main objective of this study is to investigate ‘why does China adopted the strategy of new regionalism, and is it looking for an era of US decline in the region in the post 9/11 era’? Both US and China have made noticeable diplomatic, foreign policy, and cultural advances in their appeal and influence in the region since the 9/11 era. In addition, the Chinese regional integration approach (SCO) with the Central Asian states and Russia and its implication for US geopolitical interest are closely analyzed in this paper. It is markedly considered that Beijing has adopted a couple of measures to undermine the US attention in the region, either in the form of a new regionalism policy (SCO), soft power, to the advanced multipolar system, to promote mutual and multifaceted dealings with its bordering countries. The results of this descriptive study indicate that the dynamic role of China has ultimately weakened the emerging role of the US in the region where Washington has already triggered and enhanced its bilateral relations with the Central Asian states. Moreover, this inclusive study examined China’s regionalism approach from distinguishing perspectives such as Economic assistance, oil diplomacy, and economic and political strategies in its rapid ascendance in world politics.