Untersuchungen an quartären Pyridiniumsalzen, X [1] Eine Kondensationsreaktion von 3-Cyanpyridiniumsalzen bei Einwirkung A Condensation Reaction of 3-Cyanopyridinium Salts on Addition of Alcoxides

1980 ◽  
Vol 35 (4) ◽  
pp. 490-493 ◽  
Author(s):  
Wolf-H. Gündel
Keyword(s):  
Condensation Reaction ◽  
Derivatives Of

Abstract 1-Benzyl-3-cyanopyridinium salts, in the benzyl moiety differently substituted, react in boiling alcohol with alcoxides to derivatives of hexahydro-dipyrido[l,2-a:3',2'-c]-pyrrole. At 20 °C occurs rearrangement to derivatives of 2-amino-3-pyridinecarbaldehyde.

Synthesis of some salicylic acid derivatives and determination of their acidity constants

1990 ◽  
Vol 55 (7) ◽  
pp. 1763-1768 ◽  
Author(s):  
Evgenija A. Djurendić ◽  
Terézia M. Surányi ◽  
Dušan A. Miljković
Keyword(s):  
Salicylic Acid ◽  
Condensation Reaction ◽  
Glass Electrode ◽  
Acidity Constants ◽  
Resonance Effects ◽  
Potentiometric Titration Method ◽  
Titration Data ◽  
Salicylic Acid Derivatives ◽  
Derivatives Of

Several derivatives of salicylic acid have been synthesized by the condensation reaction of methyl salicylate with α,ω-diols and α,ω-diamines, and the acidity constants of five newly prepared derivatives have been determined in 61.10% aqueous ethanol using potentiometric titration method. In order to avoid calibration of pH-meter, the standard potential of glass electrode was determined from the titration data. The results obtained are discussed with regard to different resonance effects of the ester oxygen and the amide nitrogen atoms.

scholarly journals SYNTHESIS AND RESEARCH OF NITROGEN-CONTAINING XANTHANE GUM DERIVATIVES

2020 ◽  
Vol 9 (5(74)) ◽  
pp. 57-62
Author(s):  
O.R. Ahmedov ◽  
N.Sh. Rahmatova ◽  
H.S. Talipova ◽  
Z.S. Alihonova ◽  
A.S. Turaev
Keyword(s):  
Xanthan Gum ◽  
Condensation Reaction ◽  
Oxidation States ◽  
Reaction Products ◽  
Scanning Calorimetry ◽  
Quantitative Content ◽  
Degree Of Oxidation ◽  
Physicochemical Methods ◽  
Aldehyde Groups ◽  
Derivatives Of

This study presents the results concerning the synthesis of nitrogen-containing derivatives of xanthan gum. The authors obtained xanthan gum derivatives with various oxidation states through the preliminary reaction of periodic oxidation of the polysaccharide. Through the physicochemical methods of analysis, the structure and established quantitative content of aldehyde groups in the macromolecular chain of the polysaccharide were proved. It was possible to carry out a condensation reaction with guanidine and to synthesize new macromolecular derivatives in the presence of reactive aldehyde groups in the structure of xanthan gum. The synthesized derivatives were further investigated through IR spectroscopy, thermogravimetry, differential scanning calorimetry, and elemental analysis for nitrogen content. Furthermore, it is found that the amount of guanidine and the degree of substitution in the synthesized compounds are 15.3-39.0% and 34-85 mol.%. Finally, when using modified xanthan gum with a different degree of oxidation it is possible to vary the quantitative content of guanidine and the degree ofsubstitution in the reaction products.

scholarly journals Synthesis, Sorption and Metallochromy Properties of Organosilicon Derivatives of 1-Acetylguanidine

2021 ◽  
Vol 13 (1) ◽  
pp. 78-87
Author(s):  
E.N. Oborina ◽  
◽  
A.M. Nalibayeva ◽  
V.G. Fedoseeva ◽  
I.A. Ushakov ◽  
...  
Keyword(s):  
Noble Metals ◽  
Large Scale ◽  
Condensation Reaction ◽  
Building Blocks ◽  
Test Methods ◽  
Metal Extraction ◽  
Composition And Structure ◽  
Complex Test ◽  
Derivatives Of ◽  
Polymeric Structures

Increased interest in carbofunctional organosilicon monomers (silanes) and polymers (silsesquioxanes) is associated with the fact that these compounds are promising reagents and building blocks, materials for micro-electronics, agriculture and medicine, complexones, catalysts, and efficient sorbents. Thus, functional polysilsesquioxanes surpass mineral and organic sorbents in sorption properties. Moreover, they have the highest chemical and thermal stability. Along with sorption activity carbofunctional organosilicon compounds of both monomeric and polymeric structures can possess metallochromic properties. All this paves the way for the large-scale development of analytical systems for the creation of new complex test methods for the determination, concentration and separation of metals from solutions. In the present study the functional monomer N-[3-(triethoxysilyl)propyl]acetylguanidine 1 was synthesized by the condensation reaction of 1-acetylguanidine and 3-triethoxysilyl-propylamine. Poly-N-[3-silsesquioxanyl) propyl]acetylguanidine 2 was obtained by hydrolytic polycondensation of compound 1. The composition and structure of compounds 1 and 2 were confirmed by IR and 1H NMR spectroscopy, as well as by elemental analysis. Polymer 2 was studied as a sorbent for ions of heavy metals, such as Hg (II), and noble metals Ag (I), Au (III), Rh (II), Pd (II), Pt (IV) from solutions of their salts in hydrochloric or nitric acid. For polymer 2, the values of static sorption capacities have been calculated. The latter depend on the nature of the metal and have values from 78 mg/g (for platinum) to 366 mg/g for rhodium. The graphs of the degree of metal extraction depending on the sorption time and acid concentration have been plotted. A sorption mechanism is proposed, which is realized due to the chelate interaction of the metal cation (M+) with the amide groups of compounds 1 and 2. The interaction of monomer 1, in the form of indicator paper, and polymer 2, in the powder form, with salts of the studied metals is accompanied by intense specific coloration (metallochromy). Color tables of the samples after their contact with the Ag (I), Au (III), Pd (II), Pt (IV), Rh (III), Hg (II) salts are given.

Amalgamation and Scrutinizing of Leucine Derivatives Schiff bases Complexes as Antimicrobial Agent

2021 ◽  
Vol 25 ◽  
Author(s):  
Muhammad Pervaiz ◽  
Ikram Ahmad ◽  
Zohaib Saeed ◽  
Muhammad Sagir ◽  
Umer Younas ◽  
...  
Keyword(s):  
Amino Acids ◽  
Coordination Chemistry ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Condensation Reaction ◽  
Amino Acid Derivatives ◽  
Comprehensive Review ◽  
Antimicrobial Potential ◽  
Donor Ability ◽  
Derivatives Of

: The enhanced applications of Schiff bases metal complexes of amino acid derivatives have captured the attention of researchers for the synthesis of leucine derivatives of Schiff bases metal complexes. Amino acids are considered to be essential part of food supplements as well as derivatives of Schiff bases in coordination chemistry due to their donor ability. The leucine derivatives Schiff bases ligand have been synthesized by condensation reaction between amine of leucine with aldehyde or ketone bearing molecules attached with them. These complexes were characterized by different spectroscopic tools in order to confirm their structural geometries. The structural geometries are considered to be very important in order to improve the antimicrobial potential of leucine derivative metal complexes. By taking into account the antimicrobial potential of titled compounds, a comprehensive review of leucine derivatives of Schiff bases metal complexes has been compiled.

scholarly journals Synthesis of Polyformate Esters of Vegetable Oils: Milkweed, Pennycress, and Soy

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Rogers E. Harry-O’kuru ◽  
Girma Biresaw ◽  
Brent Tisserat ◽  
Roque Evangelista
Keyword(s):  
Chain Length ◽  
Vegetable Oils ◽  
Condensation Reaction ◽  
Short Chain Length ◽  
Analogous Manner ◽  
Chain Acyl ◽  
Ready Availability ◽  
Epoxy Ring Opening ◽  
Derivatives Of ◽  
Acyl Derivatives

In a previous study of the characteristics of acyl derivatives of polyhydroxy milkweed oil (PHMWO), it was observed that the densities and viscosities of the respective derivatives decreased with increased chain length of the substituent acyl group. Thus from the polyhydroxy starting material, attenuation in viscosity of the derivatives relative to PHMWO was found in the order: PHMWO ≫ PAcMWE ≫ PBuMWE ≫ PPMWE (2332 : 1733 : 926.2 : 489.4 cSt, resp., at 40°C), where PAcMWE, PBuMWE, and PPMWE were the polyacetyl, polybutyroyl, and polypentanoyl ester derivatives, respectively. In an analogous manner, the densities also decreased as the chain length increased although not as precipitously compared to the viscosity drop. By inference, derivatives of vegetable oils with short chain length substituents on the triglyceride would be attractive in lubricant applications in view of their higher densities and possibly higher viscosity indices. Pursuant to this, we have explored the syntheses of formyl esters of three vegetable oils in order to examine the optimal density, viscosity, and related physical characteristics in relation to their suitability as lubricant candidates. In the absence of ready availability of formic anhydride, we opted to employ the epoxidized vegetable oils as substrates for formyl ester generation using glacial formic acid. The epoxy ring-opening process was smooth but was apparently followed by a simultaneous condensation reaction of the putativeα-hydroxy formyl intermediate to yield vicinal diformyl esters from the oxirane. All three polyformyl esters milkweed, soy, and pennycress derivatives exhibited low coefficient of friction and a correspondingly much lower wear scar in the 4-ball antiwear test compared to the longer chain acyl analogues earlier studied.

scholarly journals Syntheses, Evaluation and Characterization of Some 1, 3, 4-Oxadiazoles as Antimicrobial Agents

2009 ◽  
Vol 6 (4) ◽  
pp. 1133-1138 ◽  
Author(s):  
Niti Bhardwaj ◽  
S. K. Saraf ◽  
Pankaj Sharma ◽  
Pradeep Kumar
Keyword(s):  
Heterocyclic Compounds ◽  
Antimicrobial Agents ◽  
Biological Activities ◽  
Condensation Reaction ◽  
Reaction Scheme ◽  
Ring System ◽  
Indole Ring ◽  
Different Strains ◽  
Derivatives Of

1,3,4-Oxadiazoles show various biological activities and have been synthesized from different compounds. 1,3,4-oxadiazole is popularly known for its antimicrobial, anti-inflammatory, pesticidal and antihypertensive activitiesetc. It is well known that the synthesis of heterocyclic compounds tend to contain multi-structure in a molecule. The ring formation involves the condensation reaction. The challenge is to develop the ring system by incorporating the indole nucleus into it through the proposed reaction scheme. There are two free positions for the substitution in the oxadiazole ring system. In this study, it was planned to incorporate the oxadiazole ring system into indole ring. Synthesis of derivatives of 1,3,4-oxadiazoles from different benzaldehydes Characterization of the synthesized compounds along with their antimicrobial activity on different strains.

scholarly journals Synthesis, Antibacterial and Antifungal Activities for Novel Derivatives of 2,2'-(((1-benzylbenzoimidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol)

2019 ◽  
Vol 32 (1) ◽  
pp. 56
Author(s):  
Aziz Latif Jarallah ◽  
Khalid Fahad Ali ◽  
Raied Mustafa Shakir ◽  
Shaimaa Abed Saoud
Keyword(s):  
Antifungal Activity ◽  
Click Reaction ◽  
Condensation Reaction ◽  
Benzyl Bromide ◽  
Antibacterial And Antifungal Activities ◽  
Tosyl Chloride ◽  
Starting Compound ◽  
Ft Ir ◽  
Antibacterial And Antifungal ◽  
Derivatives Of

The compound 2,2'-(((1H-benzo(d)imidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) was reacted with benzyl bromide to afford compound (1) which used as row material to prepare a series of compounds through condensation reaction, the starting compound were reacted with tosyl chloride to protect the OH group  to afford compound 2, then reacted benzyl bromide to produce compound (2), then the compound (2) treated with three compounds ( 2-mercaptobenzthiazole, 2-mercaptobenimidazol and 2-chloromethyl benzimidazole) to form compounds 3a,b, 4a,b and 5a,b respectively. In the another step the click reaction of compound 2,2'-(((1H-benzo(d)imidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) with Propargyl bromide produce compound  6  which reacted with sodium azide or benzyl azide to afford the compounds 7 and 8. The synthesized compounds were characterized and measured the physical properties via the FT-IR, HNMR, besides to the CHN analysis. These newly compounds were screened their antibacterial and antifungal activity. Compounds 1, 2a and 8 showed significant   antibacterial activity as well these compounds exhibited either low or moderated antifungal activity.

scholarly journals HYDRAZIDE OF o-HYDROXYBENZOIC ACID AND ITS DERIVATIVES. SYNTHESIS AND PROPERTIES

2020 ◽  
Vol 1 (383) ◽  
pp. 14-25
Author(s):  
О. А. Nurkenov ◽  
S. D. Fazylov ◽  
M. Zh. Zhurinov ◽  
Zh. B. Satpaeva ◽  
М. Zh. Burkeev ◽  
...  
Keyword(s):  
Chemical Shifts ◽  
Condensation Reaction ◽  
13C Nmr Spectroscopy ◽  
Hydroxybenzoic Acid ◽  
Monocytic Cell ◽  
Integrated Intensity ◽  
Human Monocytic Cell ◽  
Thiosemicarbazide Derivatives ◽  
Derivatives Of

The article presents the results of a study by the authors of the article on the development of new ways of synthesis and study of the biological activity of hydrazide derivatives of o-hydroxybenzoic acid. Methods for the preparation of hydrazone, oxadiazole, thiosemicarbazide, 1,2,4-triazole-3-thionic derivatives and methods for their further modification are described. The condensation reaction of hydroxybenzoic acid hydrazides with 1-deoxy-2,3,4,6-tetra-O-acetyl-D-glucopyranosyl isothiocyanate synthesized their corresponding acetylated glycosyl-contai-ning thiosemicarbazide derivatives. The structures of the synthesized compounds were studied by 1H and 13C NMR spectroscopy, as well as by the data of two-dimensional spectra of COSY (1H-1H) and HMQC (1H-13C). The values of chemical shifts, multiplicity, and integrated intensity of 1H and 13C signals in one-dimensional NMR spectra were determined. Using spectra in the formats COSY (1Н-1Н) and HMQC (1Н-13С), homo- and heteronuclear interactions were established, confirming the structure of the compounds under study. The results of evaluating their antimicrobial, anti-inflammatory and cytotoxic activity (in vitro) on cultures of human monocytic cell lines MonoMac-6 and THP-1Blue are described.

Synthesis, Characterization and Antimicrobial Activity of New Nucleoside Analogues from Benzotriazole

2016 ◽  
Vol 10 (3) ◽  
pp. 271-278
Author(s):  
Thanaa Al-muamin ◽  
◽  
Naeemah Al-lami ◽  
Suroor Rahman ◽  
Rana Ali ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Nucleophilic Addition ◽  
Benzoyl Chloride ◽  
Antimicrobial Agents ◽  
Condensation Reaction ◽  
Nucleoside Analogues ◽  
The Novel ◽  
Ft Ir ◽  
Derivatives Of ◽  
Aromatic And Aliphatic Amines

Novel derivatives of 1-(´1, ´3, ´4, ´6-tetra benzoyl-β-D-fructofuranosyl)-1H- benzotriazole and 1-(´1, ´3, ´4, ´6-tetra benzoyl-β-D-fructofuranosyl)-1H-benzotriazole carrying Schiff bases moiety were synthesised and fully characterised. The protection of D-fructose using benzoyl chloride was synthesized, followed by nucleophilic addition/elimination between benzotriazole and chloroacetyl chloride to give 1-(1- chloroacetyl)-1H-benzotriazole. The next step was condensation reaction of protected fructose and 1-(1-chloroacetyl)-1H-benzotriazole producing a new nucleoside analogue. The novel nucleoside analogues underwent a second condensation reaction with different aromatic and aliphatic amines to provide new Schiff bases. The prepared analogues were characterised by FT-IR, 1H NMR, 13C NMR, HRMS(EI+) spectra. These analogues were tested against different bacteria to evaluate them as antimicrobial agents.

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