Three new prenylflavonol glycosides from heat-processed Epimediumkoreanum

Phytochemical investigation of the n-BuOH extract of the leaves of processed Epimedium koreanum led to the isolation of three new prenylflavonol glycosides, epimedkoresides A–C (1–3), along with the 15 known ones (4–18). The structures of the three new compounds were established on the basis of chemical and spectroscopic methods as 8-γ-hydroxy-γ,γ-dimethylpropyl-5,7,4′-trihydroxy-flavonol-3- O-β-d-glucopyranosyl(1 → 2)-α-l-rhamnopyranoside (1), 8-γ-hydroxy-γ,γ-dimethylpropyl-5,7,4′-trihydroxy-flavonol-3-O-α-l-rhamnopyranosyl(1 → 2)-α-l-rhamnopyranoside (2), and anhydroicaritin 3-O-α-l-rhamnopyranosyl(1 → 2)- α-l-rhamnopyranosyl-7-O-α-l-rhamnopyranosyl(1 → 2)-β-d-glucopyranoside (3), respectively. Additionally, partial structures were evaluated for their anti-inflammatory activity.