Komplexe von Desoxyribonucleinsäure mit Azoverbindungen und Diazinen, I DNA und 2-Amio-benzo[c]cinnolin / Azo Compound and Diazine Complexes of Desoxyribonucleic Acid, I DNA and 2-Amino-benzo[c]cinnoline

1975 ◽  
Vol 30 (1-2) ◽  
pp. 29-32
Author(s):  
Hermann Rau ◽  
Gisela Schuster
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Small Molecule ◽  
Salt Concentration ◽  
Deoxyribonucleic Acid ◽  
Desoxyribonucleic Acid ◽  
Base Pairs ◽  
Azo Compound ◽  
Complex Constant

Abstract Complex formation of deoxyribonucleic acid and 2-amino-benzo [c] cinnoline is demonstrated by spectroscopic means. The small molecule though uncharged seems to intercalate between the base pairs of the deoxyribonucleic acid like the acridines. The complex constant, however, is smaller by about two orders of magnitude. The influence of salt concentration and temperature on the equilibrium is investigated. The involvement of charge-transfer contribution is suggested.

The Nature of the Hydrogen Bond in DNA Base Pairs: The Role of Charge Transfer and Resonance Assistance

1999 ◽  
Vol 5 (12) ◽  
pp. 3581-3594 ◽  
Author(s):  
Célia Fonseca Guerra ◽  
F. Matthias Bickelhaupt ◽  
Jaap G. Snijders ◽  
Evert Jan Baerends
Keyword(s):  
Hydrogen Bond ◽  
Charge Transfer ◽  
Base Pairs ◽  
Dna Base ◽  
Dna Base Pairs

A new route towards deep desulfurization: selective charge transfer complex formation

1998 ◽  
pp. 305-306 ◽  
Author(s):  
Valérie Meille ◽  
Emmanuelle Schulz ◽  
Valérie Meille ◽  
Michel Vrinat ◽  
Marc Lemaire
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Charge Transfer Complex ◽  
Deep Desulfurization

scholarly journals DETERMINATION OF TRIMETHOPRIM BY CHARGE-TRANSFER COMPLEX FORMATION

1994 ◽  
Vol 3 (2) ◽  
pp. 132-141
Author(s):  
Mohamed El Balkiny ◽  
Gamal Ragab ◽  
Magda Ayad
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Charge Transfer Complex

scholarly journals Metal-mediated base pairs in parallel-stranded DNA

2017 ◽  
Vol 13 ◽  
pp. 2671-2681 ◽  
Author(s):  
Jens Müller
Keyword(s):  
Nucleic Acid ◽  
Complex Formation ◽  
Transition Metal Ions ◽  
Dna Duplexes ◽  
Base Pairs ◽  
Experimental Conditions ◽  
Site Specific ◽  
Glycosidic Bonds ◽  
Double Helices ◽  
Significant Extension

In nucleic acid chemistry, metal-mediated base pairs represent a versatile method for the site-specific introduction of metal-based functionality. In metal-mediated base pairs, the hydrogen bonds between complementary nucleobases are replaced by coordinate bonds to one or two transition metal ions located in the helical core. In recent years, the concept of metal-mediated base pairing has found a significant extension by applying it to parallel-stranded DNA duplexes. The antiparallel-stranded orientation of the complementary strands as found in natural B-DNA double helices enforces a cisoid orientation of the glycosidic bonds. To enable the formation of metal-mediated base pairs preferring a transoid orientation of the glycosidic bonds, parallel-stranded duplexes have been investigated. In many cases, such as the well-established cytosine–Ag(I)–cytosine base pair, metal complex formation is more stabilizing in parallel-stranded DNA than in antiparallel-stranded DNA. This review presents an overview of all metal-mediated base pairs reported as yet in parallel-stranded DNA, compares them with their counterparts in regular DNA (where available), and explains the experimental conditions used to stabilize the respective parallel-stranded duplexes.

COMPLEX FORMATION BETWEEN BASIC ANTIBIOTICS AND DEOXYRIBONUCLEIC ACID IN HUMAN PULMONARY SECRETIONS

PEDIATRICS ◽  
1965 ◽  
Vol 36 (5) ◽  
pp. 714-720
Author(s):  
Joseph L. Potter ◽  
LeRoy W. Matthews ◽  
Samuel Spector ◽  
Joy Lemm
Keyword(s):  
Cystic Fibrosis ◽  
Sodium Chloride ◽  
Complex Formation ◽  
Chain Length ◽  
Deoxyribonucleic Acid ◽  
Antimicrobial Agents ◽  
Dnase I ◽  
Two Samples

1. Complex formation and precipitation of DNA by neomycin, with consequent inactivation of the antibiotic, has been shown to occur in the pulmonary secretions of patients with cystic fibrosis. 2. Highly polymerized DNA from a variety of sources, as well as two samples of RNA, were precipitated by neomycin in vitro. Polymixin, kanamycin, colymycin, and streptomycin similarly co-precipitate with DNA in vitro. 3. The minimum chain length of polynucleotide required for precipitation in the DNA-neomycin system was 10. 4. The complex is readily attacked by DNase I resulting in the splitting of the DNA and the liberation of the antibiotic. Both components of the complex are solubilized in M sodium chloride. 5. The resistance of purulent foci of infection to therapy with basic antimicrobial agents may, in part, be due to the complex formation with the high levels of DNA found at the site of infection.

scholarly journals Frequency and hydrogen bonding of nucleobase homopairs in small molecule crystals

2020 ◽  
Vol 48 (15) ◽  
pp. 8302-8319
Author(s):  
Małgorzata Katarzyna Cabaj ◽  
Paulina Maria Dominiak
Keyword(s):  
Hydrogen Bonding ◽  
Hydrogen Bonds ◽  
Crystal Structures ◽  
Small Molecule ◽  
Base Pair ◽  
Base Pairs ◽  
Standard Pattern ◽  
Planar Structures ◽  
Structural Database ◽  
Derivatives Of

Abstract We used the high resolution and accuracy of the Cambridge Structural Database (CSD) to provide detailed information regarding base pairing interactions of selected nucleobases. We searched for base pairs in which nucleobases interact with each other through two or more hydrogen bonds and form more or less planar structures. The investigated compounds were either free forms or derivatives of adenine, guanine, hypoxanthine, thymine, uracil and cytosine. We divided our findings into categories including types of pairs, protonation patterns and whether they are formed by free bases or substituted ones. We found base pair types that are exclusive to small molecule crystal structures, some that can be found only in RNA containing crystal structures and many that are native to both environments. With a few exceptions, nucleobase protonation generally followed a standard pattern governed by pKa values. The lengths of hydrogen bonds did not depend on whether the nucleobases forming a base pair were charged or not. The reasons why particular nucleobases formed base pairs in a certain way varied significantly.

Facile addition of E–H bonds to a dicarbondiphosphide

2020 ◽  
Vol 49 (19) ◽  
pp. 6384-6390 ◽  
Author(s):  
Xu Zhang ◽  
Xiaodan Chen ◽  
Haojiang Zhai ◽  
Shihua Liu ◽  
Chenyang Hu ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Small Molecule

Charge transfer at P atoms in an N-heterocyclic carbene stabilized 6π-electron aromatic dicarbondiphosphide 1 has been observed upon interaction with a variety of small molecule substrates that feature a polar E–H bond (E = C, N, and O).

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