Nanoparticle-mediated delivery of therapeutic genes: focus on miRNA therapeutics

2013 ◽  
Vol 10 (9) ◽  
pp. 1259-1273 ◽  
Author(s):  
Muthunarayanan Muthiah ◽  
In-Kyu Park ◽  
Chong-Su Cho
Keyword(s):  
Mirna Therapeutics ◽  
Therapeutic Genes

scholarly journals Noncoding RNA in Cholangiocarcinoma

2018 ◽  
Vol 39 (01) ◽  
pp. 013-025 ◽  
Author(s):  
Massimiliano Salati ◽  
Chiara Braconi
Keyword(s):  
Clinical Practice ◽  
Early Diagnosis ◽  
Cancer Cells ◽  
Noncoding Rna ◽  
Functional Role ◽  
Noncoding Rnas ◽  
Radical Resection ◽  
Dismal Prognosis ◽  
Specific Symptoms ◽  
Mirna Therapeutics

AbstractCholangiocarcinomas (CCAs) are tumors with a dismal prognosis. Early diagnosis is a key challenge because of the lack of specific symptoms, and the curability rate is low due to the difficulty in achieving a radical resection and the intrinsic chemoresistance of CCA cells. Noncoding RNAs (ncRNAs) are transcripts that are not translated into proteins but exert their functional role by regulating the transcription and translation of other genes. The discovery of the first ncRNA dates back to 1993 when the microRNA (miRNA) lin-4 was discovered in Caenorhabditis elegans. Only 10 years later, miRNAs were shown to play an oncogenic role in cancer cells and within 20 years miRNA therapeutics were tested in humans. Here, the authors review the latest evidence for a role for ncRNAs in CCA and discuss the promise and challenges associated with the introduction of ncRNAs into clinical practice.

scholarly journals PD6-1-4: Potential of therapeutic genes for small cell lung cancer gene therapy

2007 ◽  
Vol 2 (8) ◽  
pp. S425-S426
Author(s):  
Camilla L. Christensen ◽  
Nina Pedersen ◽  
Mikkel Rohde ◽  
Hans S. Poulsen
Keyword(s):  
Lung Cancer ◽  
Gene Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Gene Therapy ◽  
Small Cell ◽  
Cancer Gene ◽  
Small Cell Lung ◽  
Therapeutic Genes
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