scholarly journals Short-term Effects of Transcranial Near-Infrared Photobiomodulation on Motor Performance in Healthy Human Subjects: An Experimental SingleBlind Randomized Clinical Trial

2019 ◽  
Vol 10 (4) ◽  
pp. 317-323
Author(s):  
Atefeh Fekri ◽  
Ali Jahan ◽  
Maryam Moghadam Salimi ◽  
Ali E. Oskouei
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Motor Performance ◽  
Near Infrared ◽  
Human Subjects ◽  
Laser Source ◽  
Short Term ◽  
Healthy Human ◽  
Healthy Human Subjects ◽  
Short Term Effects

Introduction: Transcranial near-infrared photobiomodulation (NIR-PBM) is a new noninvasive procedure which transcranially applies a near-infrared wavelength to the scalp with a laser or a light-emitting diode (LED) source. Improvement in the neurological or psychological symptoms has been reported following light irradiation. However, to our knowledge, there is no study to investigate the effects of transcranial NIR-PBM on motor performance directly. Therefore, the objective of this study was to investigate the short-term effects of transcranial NIR-PBM on motor performance in healthy human subjects. Methods: In this experimental single-blind randomized clinical trial study, 56 right-handed healthy participants, whose ages ranged from 18 to 30, were randomly assigned to (1) Real transcranial NIR-PBMC3 group (n=14), (2) Sham transcranial NIR-PBMC3 group (n=14), (3) Real transcranial NIR-PBMC4 group (n=14), and (4) Sham transcranial NIR-PBMC4 group (n=14). We applied the 808 nm laser with irradiation energy density of 60 J/cm2 and power density of 200 mw/cm2 to the C3 or C4 points of the scalp. The number of finger taps as an indicator of motor performance was assessed by the finger-tapping test (FTT) before and after irradiation of transcranial NIR-PBM on the corresponding points of the scalp for 5 minutes. Results: The results showed that the number of finger taps in both right and left hands following the use of transcranial NIR-PBM in the real transcranial NIR-PBMC3 group significantly increased (P<0.05). Conclusion: We concluded that using transcranial NIR-PBM with a laser source on C3 point of the motor cortex in right-handed healthy people can increase the number of finger taps in both hands as an indicator of motor performance improvement.

Double-Blind, Placebo-Controlled, Randomized Clinical Trial of the Effect of the Dietary Supplement S-Adenosyl-L-Methionine (AdoMet) on Plasma Homocysteine (Hcy) Levels in Healthy Human Subjects.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 1481-1481
Author(s):  
Michael A. Thompson ◽  
Brent A. Bauer ◽  
Laura L. Loehrer ◽  
Stephen S. Cha ◽  
Jayawant N. Mandrekar ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Placebo Group ◽  
Randomized Clinical Trial ◽  
Primary Endpoint ◽  
Human Subjects ◽  
Nutritional Supplement ◽  
Healthy Human ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Healthy Human Subjects

Abstract BACKGROUND: S-adenosyl-L-methionine (AdoMet or SAM-e®) is a commonly used nutritional supplement available in the United States since 1999. AdoMet is metabolized to homocysteine (Hcy), a potential cardiovascular risk factor. A few open-label, single-arm studies have reported on the effect of exogenous AdoMet on the levels of Hcy in humans; however, this has not been tested in a double-blind, randomized clinical trial. As a nutritional supplement, AdoMet is subject only to limited regulation by the FDA, despite being used to treat clinical diseases such as depression and osteoarthritis. AdoMet is the methyl donor for small molecule, DNA, RNA, and protein methylation reactions; therefore, further understanding the biology of the AdoMet/Hcy system is important. We hypothesized that exogenous AdoMet would increase plasma Hcy levels. METHODS: In a double-blind, placebo-controlled, randomized clinical trial, 93 healthy human subjects were screened and 52 were treated with placebo (26) or 800 mg per day AdoMet (26) pills for 4 weeks. Pre- and post-treatment Hcy levels were measured. The primary endpoint was change in Hcy level. Secondary endpoints included an interim Hcy level, high sensitivity C-reactive protein (hsCRP) levels, lipid profile, and transaminases. Exclusion criteria included pregnancy and concurrent use of medications associated with changes in Hcy. RESULTS: Of 52 subjects enrolled, 45 were evaluable at the end of treatment. Subject characteristics and dropout rates were similar between placebo and control groups. Adverse events were minor and were not different between placebo and AdoMet. The primary endpoint, change in Hcy, was not significantly different between the groups (mean (umol/L), baseline: 7.43 (placebo), 8.25 (AdoMet), P=0.358; 4 week: 7.66 (placebo), 8.06 (AdoMet), P = 0.683; Baseline − 4 week: 0.23 (placebo), −0.19 (AdoMet), P = 0.427). No statistically significant difference in change in Hcy or hsCRP at 2 or 4 weeks was noted. This was true for both absolute differences as well as relative percent changes. A small decrease in ALT was observed at 2 weeks in the AdoMet group compared to the placebo group (P = 0.027). AdoMet is used in the treatment of liver diseases. There was a small, but statistically significant (P = 0.028) decrease in total cholesterol in the AdoMet group as compared to the placebo group. Interestingly, a subject with the highest baseline Hcy level had a decline in Hcy on AdoMet. Study limitations include no evaluation of AdoMet serum levels or measurement of the effect of AdoMet on DNA methylation patterns. CONCLUSIONS: AdoMet seems well tolerated and in a dose of 800 mg/day for 4 weeks does not appear to significantly affect Hcy levels in the blood. Future clinical trials of AdoMet should monitor Hcy levels with extended use of AdoMet to confirm its safety with long term use. Clinicaltrials.gov ID: NCT00284011.

scholarly journals Short-term effects of manipulative treatment versus a therapeutic home exercise protocol for chronic cervical pain: A randomized clinical trial

2018 ◽  
Vol 31 (1) ◽  
pp. 133-145 ◽  
Author(s):  
Xabier Galindez-Ibarbengoetxea ◽  
Igor Setuain ◽  
Robinson Ramírez-Velez ◽  
Lars L. Andersen ◽  
Miriam González-Izal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Home Exercise ◽  
Cervical Pain ◽  
Exercise Protocol ◽  
Short Term ◽  
Short Term Effects

Short-term effects of spinal thrust joint manipulation in patients with chronic neck pain: a randomized clinical trial

2012 ◽  
Vol 27 (6) ◽  
pp. 504-512 ◽  
Author(s):  
Manuel Saavedra-Hernández ◽  
Manuel Arroyo-Morales ◽  
Irene Cantarero-Villanueva ◽  
Carolina Fernández-Lao ◽  
Adelaida M Castro-Sánchez ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Neck Pain ◽  
Randomized Clinical Trial ◽  
Chronic Neck Pain ◽  
Short Term ◽  
Short Term Effects ◽  
Thrust Joint Manipulation

scholarly journals Facial Vibrotactile Stimulation Activates the Parasympathetic Nervous System: Study of Salivary Secretion, Heart Rate, Pupillary Reflex, and Functional Near-Infrared Spectroscopy Activity

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Hisao Hiraba ◽  
Motoharu Inoue ◽  
Kanako Gora ◽  
Takako Sato ◽  
Satoshi Nishimura ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Infrared Spectroscopy ◽  
Near Infrared ◽  
Human Subjects ◽  
Vibrotactile Stimulation ◽  
Functional Near Infrared Spectroscopy ◽  
Healthy Human ◽  
Healthy Human Subjects ◽  
Stimulation Of

We previously found that the greatest salivation response in healthy human subjects is produced by facial vibrotactile stimulation of 89 Hz frequency with 1.9 μm amplitude (89 Hz-S), as reported by Hiraba et al. (2012, 20011, and 2008). We assessed relationships between the blood flow to brain via functional near-infrared spectroscopy (fNIRS) in the frontal cortex and autonomic parameters. We used the heart rate (HRV: heart rate variability analysis in RR intervals), pupil reflex, and salivation as parameters, but the interrelation between each parameter and fNIRS measures remains unknown. We were to investigate the relationship in response to established paradigms using simultaneously each parameter-fNIRS recording in healthy human subjects. Analysis of fNIRS was examined by a comparison of various values between before and after various stimuli (89 Hz-S, 114 Hz-S, listen to classic music, and “Ahh” vocalization). We confirmed that vibrotactile stimulation (89 Hz) of the parotid glands led to the greatest salivation, greatest increase in heart rate variability, and the most constricted pupils. Furthermore, there were almost no detectable differences between fNIRS during 89 Hz-S and fNIRS during listening to classical music of fans. Thus, vibrotactile stimulation of 89 Hz seems to evoke parasympathetic activity.

scholarly journals Short-Term Effects of Cervical Kinesio Taping on Pain and Cervical Range of Motion in Patients With Acute Whiplash Injury: A Randomized Clinical Trial

2009 ◽  
Vol 39 (7) ◽  
pp. 515-521 ◽  
Author(s):  
Javier GonzáLez-Iglesias ◽  
César Fernández-de-las-Peñas ◽  
Joshua Cleland ◽  
Peter Huijbregts ◽  
Maria Del Rosario Gutiérrez-Vega
Keyword(s):  
Clinical Trial ◽  
Range Of Motion ◽  
Randomized Clinical Trial ◽  
Whiplash Injury ◽  
Short Term ◽  
Cervical Range Of Motion ◽  
Kinesio Taping ◽  
Short Term Effects

scholarly journals Combined effects of moderate exercise and short-term fasting on markers of immune function in healthy human subjects

2020 ◽  
Vol 318 (6) ◽  
pp. R1103-R1115
Author(s):  
Frank C. Mooren ◽  
Karsten Krueger ◽  
Robert Ringseis ◽  
Klaus Eder ◽  
Gerhard Liebisch ◽  
...  
Keyword(s):  
Immune Function ◽  
Human Subjects ◽  
Moderate Exercise ◽  
Exercise Protocol ◽  
Short Term ◽  
Healthy Human ◽  
Acute Bout ◽  
T Cell Apoptosis ◽  
Healthy Human Subjects ◽  
Neutrophil Oxidative Burst

This study aimed to investigate the effects of a short-term (36 h) fasting period combined with an acute bout of exercise on markers of immune function and inflammation in healthy human subjects. Fourteen moderately trained male subjects (aged 19–39 yr) participated in a 36-h fasting trial (FA-T), followed by an acute bout of moderate exercise (60% V̇o2max). After 1 wk, the same subjects, as their own control, participated in a nonfasting trial (NFA-T) in which they performed an exercise trial of the same duration and intensity. Blood samples were taken before, immediately after, and 1 h after each exercise bout and analyzed for several immunological and metabolic markers. At baseline, fasting subjects showed lower levels of T cell apoptosis, lymphocyte-proliferative responses, IL-6, monocyte chemoattractant protein-1 (MCP-1), insulin, and leptin ( P < 0.05) as well as higher levels of neutrophil oxidative burst and thiobarbituric acid reactive substances (TBARS) than those in the NFA-T ( P < 0.05). After the exercise protocol, fasted subjects revealed higher T cell apoptosis, neutrophil oxidative burst, TBARS, TNFα, and MCP-1 levels as well as lower levels of lymphocyte-proliferative response, IL-6, insulin, and leptin than those in the NFA-T ( P < 0.05). Short-term fasting aggravates perturbations in markers of immune function, and inflammation was induced by an acute moderate-intensity exercise protocol.

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