Renal damages in patients with major β-thalassemia

Introduction: Numerous studies have shown the presence of renal dysfunction in patients with beta thalassemia major (βTM). According to iron overload and effects on renal, evaluation of renal function in βTM can cause better control of them. Objectives: In this study, we evaluated renal function in children and adults with βTM. Patients and Methods: Sixty patients (38 male and 22 female) with βTM, and 60 healthy control subjects (25 males and 35 females), were participated in this cross-sectional study. Biochemical and urine analysis were conducted to evaluate renal function. Additionally, patients were classified based on the administration of iron chelators including deferoxamine (Desferal), deferiprone (L1), deferasirox (Exjade) and combination therapy. Results: Renal dysfunctions such as hyperfiltration and proteinuria were common findings in patients compared with the normal group. Hypercalciuria was found only in patients groups receiving Exjade. Hyperfiltration was detected in all patients. Proteinuria was no related to drug administration. Conclusion: We found a high percentage of our βTM patients who had renal dysfunction as evidenced by proteinuria and hyperfiltration.

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A cross-sectional study of metabolic and endocrine complications in beta-thalassemia major

Annals of Saudi Medicine ◽

10.4103/0256-4947.51683 ◽

2008 ◽

Vol 28 (5) ◽

pp. 361 ◽

Cited By ~ 9

Author(s):

Farzad Najafipour ◽

Akbar Aliasgarzadeh ◽

Naser Aghamohamadzadeh ◽

Amir Bahrami ◽

Majid Mobasri ◽

...

Keyword(s):

Thalassemia Major ◽

Cross Sectional Study ◽

Beta Thalassemia ◽

Sectional Study ◽

Cross Sectional ◽

Beta Thalassemia Major ◽

Endocrine Complications

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Endocrine complications of beta-thalassemia major patients—Cross-sectional study

International Journal of Blood Transfusion and Immunohematology ◽

10.5348/100051z02ak2020ak ◽

2020 ◽

Vol 10 ◽

pp. 1

Author(s):

Attanayaka Mudiyanse Dilhara Sewwandi Karunaratna ◽

Rasnayaka Mudiyanselage Mudiyanse

Keyword(s):

Thalassemia Major ◽

Cross Sectional Study ◽

Beta Thalassemia ◽

Sectional Study ◽

Cross Sectional ◽

Beta Thalassemia Major ◽

Endocrine Complications

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Prevalence of Malocclusion in Patients with Thalassemia Major: A Cross-sectional Study

Iranian Journal of Orthodontics ◽

10.5812/ijo.117155 ◽

2021 ◽

Vol 15 (2) ◽

Author(s):

Parastoo Namdar ◽

Atena Shiva ◽

Tahura Etezadi ◽

Jamshid Yazdani Charati ◽

Hossein Karami ◽

...

Keyword(s):

Thalassemia Major ◽

Cross Sectional Study ◽

Iranian Population ◽

Beta Thalassemia ◽

Practical Training ◽

Sectional Study ◽

Cross Sectional ◽

Significant Difference ◽

Adolescents And Adults ◽

And Gender

Background: Iran lies in the world's thalassemia belt; accordingly, the beta‐thalassemia gene is carried by 4% of the Iranian population. Due to the dearth of research and literature available on the prevalence of malocclusions in the Iranian population with beta-thalassemia major, this study was conducted to determine the prevalence and severity of facial abnormalities among patients who were referred to Bu-Ali Sina Hospital, Sari, Iran. Methods: This descriptive cross-sectional study was conducted on 200 patients with thalassemia major who were referred to the care unit of Bu-Ali Sina teaching and therapeutic Hospital, Sari, Iran, in 2018. The patients were then visited by a trained dentist who had been given the necessary theoretical and practical training. Malocclusion was classified based on Angle's classification. Spacing, overcrowding, overjet, and overbite were measured, and the distances were recorded based on a checklist. Results: The prevalence of malocclusions obtained was 87.5%, which included malocclusions of Class I (34%), Class II (31%), and Classes III (22%) amongst patients. There was no significant relationship between the type of malocclusion and gender (P = 0.77). Moreover, no significant difference was observed among patients with thalassemia major and different classes of malocclusions in terms of age both in males (P = 0.49) and females (P = 0.58). Conclusions: Malocclusions are common among adolescents and adults with thalassemia, which is not associated with age or gender. Therefore, patients should be regularly visited and followed up by a dentist to manage and control their dental problems. In addition, effective and preventive measures, as well as health education should be seriously considered in these patients.

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