scholarly journals Serum ferritin levels and irregular use of iron chelators predict liver iron load in patients with major beta thalassemia: a cross-sectional study

2019 ◽  
Vol 60 (5) ◽  
pp. 405-413 ◽  
Author(s):  
Soheila Sobhani ◽  
Farzaneh Rahmani ◽  
Maryam Rahmani ◽  
Marzieh Askari ◽  
Farzad Kompani
Keyword(s):  
Serum Ferritin ◽  
Cross Sectional Study ◽  
Iron Chelators ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Liver Iron ◽  
Cross Sectional ◽  
Iron Load

scholarly journals Renal damages in patients with major β-thalassemia

2019 ◽  
Vol 9 (1) ◽  
pp. e02-e02
Author(s):  
Malihe Najafpour ◽  
Majid Farshdousti-Hagh ◽  
Ali Akbar Movasagpoor-Akbari ◽  
Abbas-Ali Hosein-Pour Feyzi ◽  
Majid Malaki
Keyword(s):  
Renal Function ◽  
Renal Dysfunction ◽  
Urine Analysis ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Iron Chelators ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Healthy Control

Introduction: Numerous studies have shown the presence of renal dysfunction in patients with beta thalassemia major (βTM). According to iron overload and effects on renal, evaluation of renal function in βTM can cause better control of them. Objectives: In this study, we evaluated renal function in children and adults with βTM. Patients and Methods: Sixty patients (38 male and 22 female) with βTM, and 60 healthy control subjects (25 males and 35 females), were participated in this cross-sectional study. Biochemical and urine analysis were conducted to evaluate renal function. Additionally, patients were classified based on the administration of iron chelators including deferoxamine (Desferal), deferiprone (L1), deferasirox (Exjade) and combination therapy. Results: Renal dysfunctions such as hyperfiltration and proteinuria were common findings in patients compared with the normal group. Hypercalciuria was found only in patients groups receiving Exjade. Hyperfiltration was detected in all patients. Proteinuria was no related to drug administration. Conclusion: We found a high percentage of our βTM patients who had renal dysfunction as evidenced by proteinuria and hyperfiltration.

Uncertain crisis time affects psychosocial dimensions in beta-thalassemia patients during Covid-19 pandemic: A cross-sectional study

2021 ◽  
pp. 135910532110499
Author(s):  
Chiara Cerami ◽  
Gaia Chiara Santi ◽  
Irene Sammartano ◽  
Zelia Borsellino ◽  
Liana Cuccia ◽  
...  
Keyword(s):  
Well Being ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Key Factors ◽  
Chronic Patients ◽  
Cross Sectional ◽  
Life Habits ◽  
Anxiety Levels ◽  
Anxiety Depression

Psychosocial variables are key factors influencing the delicate equilibrium of chronic patients during crisis time. In this study, we explored distress, anxiety, depression, loneliness, coping strategies, and changes in life habits in 43 beta-thalassemia patients and 86 controls during Covid-19 pandemic. Patients showed higher anxiety levels and a predominant transcendent coping profile compared to controls. Patients significantly differed from controls in outdoor habits. Social isolation and habits changes in uncertain life-threaten situations as Covid-19 pandemic are particularly detrimental in fragile beta-thalassemia patients. Structured support interventions are needed to promote well-being in the Covid-19 era.

scholarly journals A cross-sectional study of metabolic and endocrine complications in beta-thalassemia major

2008 ◽  
Vol 28 (5) ◽  
pp. 361 ◽  
Author(s):  
Farzad Najafipour ◽  
Akbar Aliasgarzadeh ◽  
Naser Aghamohamadzadeh ◽  
Amir Bahrami ◽  
Majid Mobasri ◽  
...  
Keyword(s):  
Thalassemia Major ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Beta Thalassemia Major ◽  
Endocrine Complications

scholarly journals A prospective cross-sectional study of thyroid dysfunction in transfusion- dependent beta-thalassemia patients

2021 ◽  
Vol 8 (5) ◽  
pp. 183-186
Author(s):  
Channanayaka Chandrashekhar ◽  
Manovihari Vuyyuru ◽  
Prajwala Hassan Vasudev ◽  
George Mathew Panachiyil ◽  
Tirin Babu
Keyword(s):  
Thyroid Dysfunction ◽  
Cross Sectional Study ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Iron deficiency among pregnant women attending an antenatal clinic in Northern Uganda: a cross-sectional study

2019 ◽  
Author(s):  
Samson Udho ◽  
Joyce Nankumbi ◽  
Mariam Namutebi ◽  
Grace Ndeezi ◽  
Joshua Epuitai ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Serum Ferritin ◽  
Antenatal Clinic ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Third Trimester ◽  
Cross Sectional ◽  
Iron Supplements ◽  
The Third

Abstract Background Iron deficiency is a leading cause of anemia among pregnant women in Uganda. However, due to the high cost of biochemical tests required to determine iron deficiency, the prevalence and factors associated with iron deficiency remain largely unstudied in our setting. Therefore, this study aimed at determining the prevalence of iron deficiency and its associated factors among pregnant women attending an antenatal clinic, Lira District-Uganda.Methods A cross-sectional study was conducted among 320 pregnant women attending an antenatal clinic at Lira Regional Referral Hospital. Maternal serum ferritin was used as a measure of iron deficiency and was determined using a Cobas 6000 Automated Analyzer. Iron deficiency was based on serum ferritin of <30 μg/L. A semi-structured questionnaire was used to obtain the characteristics of the study participants. Binary and multivariate logistic regression were performed to identify the associated factors.Results The prevalence of iron deficiency was 45%. Non-adherence to iron supplements (AOR: 2.05 95% CI: 1.02-4.12) & third trimester pregnancy (AOR: 1.88 95% CI: 1.20-2.94) were significantly associated with iron deficiency during pregnancy.Conclusion Nearly 5 in 10 of the participants had iron deficiency. Iron deficiency during pregnancy was associated with non-adherence to iron supplements and being in the third trimester of pregnancy. Midwives should encourage pregnant women to adhere to iron supplements during pregnancy especially pregnant women who are in the third trimester.

BODY GROWTH IN COOLEY'S ANEMIA (HOMOZYGOUS BETA-THALASSEMIA) WITH A CORRELATIVE STUDY AS TO OTHER ASPECTS OF THE ILLNESS IN 138 CASES

PEDIATRICS ◽  
1972 ◽  
Vol 50 (1) ◽  
pp. 92-99
Author(s):  
John Logothetis ◽  
Ruth B. Loewenson ◽  
Olga Augoustaki ◽  
Joanna Economidou ◽  
Mathios Constantoulakis
Keyword(s):  
Head Circumference ◽  
Cross Sectional Study ◽  
Body Growth ◽  
Beta Thalassemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Correlative Study ◽  
Significant Magnitude ◽  
Cooley's Anemia

A cross-sectional study of 138 patients with Cooley's anemia, from 2 to 28 years of age, demonstrated retardation in height and weight except for children under the age of 4 years. Head circumference showed no consistent deviation from normal. A tendency was found for both height and weight to fall further behind the normal average with increasing age during the growing years. The degree of retardation appeared of significant magnitude only by the age of 9 to 10 years which is probably the age when the retardation in growth became noticeable to the observer. The degree of anemia showed only slight correlation with the degree of retardation in height and weight. Systemic abnormalities, however, that reflect the severity of the illness appeared to parallel the retardation of growth.

scholarly journals Association Between Dietary Iron Intake and Serum Ferritin and Severe Headache or Migraine

2021 ◽  
Vol 8 ◽  
Author(s):  
Shu-Han Meng ◽  
Hai-Bo Zhou ◽  
Xin Li ◽  
Ming-Xue Wang ◽  
Li-Xin Kang ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Serum Ferritin ◽  
Cross Sectional Study ◽  
Severe Headache ◽  
Dietary Iron ◽  
Iron Intake ◽  
Sectional Study ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
Age Related

Background: Dietary iron intake and serum ferritin in relation to severe headache or migraine remain largely unknown. Therefore, we investigated the associations between dietary iron intake and serum ferritin with severe headache or migraine among American adults.Methods: This cross-sectional study included 7,880 adults (≥20 years) from the National Health and Nutrition Examination Surveys (NHANES) of America from 1999 to 2004. We performed multivariable logistic regression and restricted cubic spline (RCS) regression to assess the association of dietary iron and serum ferritin with severe headache or migraine.Results: Most women aged 20–50 years consumed less dietary iron than their recommended dietary allowances. Dietary iron intake was inversely associated with severe headache or migraine in women aged 20–50 years. For women over 50 years, serum ferritin was negatively associated with severe headache or migraine. For men, there was no significant relationship between dietary iron and serum ferritin, and severe headache or migraine.Conclusions: Dietary iron intake has different effects on migraine in women of different ages, and this different effect may be due to age-related menstrual changes. Women aged 20–50 years should have a higher awareness of RDA and increase their dietary iron intake if needed, which may play an important role in preventing severe headache or migraine. Higher serum ferritin levels in women aged 50 and above may have a protective effect against migraine.

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