scholarly journals Absence of Tumor Necrosis Factor-  Does Not Affect Motor Neuron Disease Caused by Superoxide Dismutase 1 Mutations

2006 ◽  
Vol 26 (44) ◽  
pp. 11397-11402 ◽  
Author(s):  
G. Gowing ◽  
F. Dequen ◽  
G. Soucy ◽  
J.-P. Julien
Keyword(s):  
Superoxide Dismutase ◽  
Tumor Necrosis Factor ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Tumor Necrosis ◽  
Superoxide Dismutase 1 ◽  
Necrosis Factor

Tumor necrosis factor-α down-regulates human Cu/Zn superoxide dismutase 1 promoter via JNK/AP-1 signaling pathway

2006 ◽  
Vol 41 (5) ◽  
pp. 709-721 ◽  
Author(s):  
Valéry Afonso ◽  
Guilherme Santos ◽  
Pascal Collin ◽  
Abdel-Majid Khatib ◽  
Dragoslav R. Mitrovic ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Tumor Necrosis Factor ◽  
Signaling Pathway ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Superoxide Dismutase 1 ◽  
Factor Α ◽  
Necrosis Factor

The effect of tumor necrosis factor-α on human malignant glial cells

1992 ◽  
Vol 76 (4) ◽  
pp. 652-659 ◽  
Author(s):  
Rolando F. Del Maestro ◽  
Monica Lopez-Torres ◽  
Warren B. McDonald ◽  
Eric C. Stroude ◽  
Indrasen S. Vaithilingam
Keyword(s):  
Superoxide Dismutase ◽  
Tumor Necrosis Factor ◽  
Cell Line ◽  
Tumor Necrosis ◽  
Manganese Superoxide Dismutase ◽  
Tumor Necrosis Factor Α ◽  
Superoxide Dismutase Activity ◽  
Manganese Superoxide ◽  
Factor Α ◽  
Necrosis Factor

✓ The influence of human recombinant tumor necrosis factor-α has been assessed on a cell line (U-251) derived from a human malignant glial tumor. The results of this study demonstrate that tumor necrosis factor-α at doses of 50 and 100 ng/ml: 1) did not have cytotoxic or cytostatic effects on the U-251 cell line; 2) significantly increased the intracellular activity of manganese superoxide dismutase but had no effect on copper and zinc superoxide dismutase, catalase, or glutathione peroxidase activity; and 3) did not significantly alter the intracellular or extracellular general protease and collagenase type IV activity of these cells. The resistance of the U-251 cell line to tumor necrosis factor-α cytotoxicity may be related in part to the high intrinsic manganese superoxide dismutase activity present in this cell line combined with the ability of this cell line to induce substantial amounts of protective manganese superoxide dismutase activity in response to tumor necrosis factor-α.

P082 Interleukin (IL)-6 deficiency does not affect motor neuron disease caused by superoxide dismutase 1 mutation

Cytokine ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 545
Author(s):  
X. Yongmei ◽  
M. Fujimoto ◽  
T. Ohkawara ◽  
L. Yang ◽  
S. Serada ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Superoxide Dismutase 1

scholarly journals PSIX-9 Dietary β-sitosterol improves immunity and antioxidant status in broilers

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 346-346
Author(s):  
Yefei Cheng ◽  
Yueping Chen ◽  
Chao Wen ◽  
Yanmin Zhou
Keyword(s):  
Superoxide Dismutase ◽  
Tumor Necrosis Factor ◽  
Immunoglobulin G ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Control Group ◽  
Hepatic Glutathione ◽  
Factor Α ◽  
Necrosis Factor ◽  
Serum Tumor Necrosis

Abstract The application effects of phytosterols on poultry production have been reported. However, due to the mixed compositions, it is difficult to explain their action mode and physiological functions. β-sitosterol, the most abundant phytosterol, is naturally widespread in plant products. Information, however, is scarce in terms of effects of β-sitosterol on broilers. This research therefore investigated effects of dietary β-sitosterol with different levels on immunity and antioxidant capacity in broilers. Two hundred and forty one-day-old chicks were randomly allocated into five treatments of six replicates. Chickens in the five groups were fed a basal diet supplemented with 0 (control group), 40, 60, 80, and 100 mg/kg β-sitesterol for 42 days, respectively. Data were analyzed by one-way analysis of variance. Polynomial contrasts were used to test the linear and quadratic response to β-sitosterol levels. Difference among groups was evaluated using Tukey’s test, which was considered significant if P < 0.05. Dietary β-sitosterol linearly increased (P < 0.05) contents of serum immunoglobulin G and hepatic glutathione, activities of serum superoxide dismutase and catalase, whereas linearly decreased (P < 0.05) concentrations of serum tumor necrosis factor α and hepatic malondialdehyde. Serum interleukin 1β level was linearly and quadratically reduced by β-sitosterol inclusion (P < 0.05). Compared with the control group, dietary β-sitosterol with higher levels than 60 mg/kg increased concentrations of serum immunoglobulin G and hepatic glutathione, activities of serum superoxide dismutase and catalase (P < 0.05), whereas decreased serum tumor necrosis factor α content (P < 0.05). Its dosages higher than 40 mg/kg reduced serum interleukin 1β content (P < 0.05), and 100 mg/kg of which lowered hepatic malondialdehyde concentration (P < 0.05). The results indicated that dietary β-sitosterol could improve immunity and antioxidant ability in broilers. Also, a level of 80 mg/kg β-sitosterol supplementation was recommended into broiler diet.

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