scholarly journals Insulin-Like Growth Factor-I Is Necessary for Neural Stem Cell Proliferation and Demonstrates Distinct Actions of Epidermal Growth Factor and Fibroblast Growth Factor-2

2001 ◽  
Vol 21 (18) ◽  
pp. 7194-7202 ◽  
Author(s):  
Yvan Arsenijevic ◽  
Samuel Weiss ◽  
Bernard Schneider ◽  
Patrick Aebischer
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Stem Cell Proliferation ◽  
Neural Stem Cell Proliferation ◽  
Factor I ◽  
Epidermal Growth

Combinatorial effects of epidermal growth factor, fibroblast growth factor 2 and insulin-like growth factor 1 on trophoblast cell proliferation and embryogenesis in cattle

2017 ◽  
Vol 29 (2) ◽  
pp. 419 ◽  
Author(s):  
Ming Xie ◽  
Sarah R. McCoski ◽  
Sally E. Johnson ◽  
Michelle L. Rhoads ◽  
Alan D. Ealy
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Culture Medium ◽  
Trophoblast Cell ◽  
Fibroblast Growth Factor 2 ◽  
Bovine Embryo ◽  
Fibroblast Growth ◽  
Cooperative Interactions ◽  
Epidermal Growth

Uterine secretions are crucial for conceptus development in mammals. This is especially important for species that undergo extended preimplantation development, like cattle and other ungulates. The present study examined cooperative interactions for epidermal growth factor (EGF), fibroblast growth factor-2 (FGF2) and insulin-like growth factor-1 (IGF1) on the proliferation of the bovine trophoblast cell line CT1 and bovine embryo development. Proliferation of CT1 cells increased after supplementation of the culture medium with 10 ng mL–1 EGF, 10 ng mL–1 FGF2 or 50 ng mL–1 IGF1, as well as with any combination of two factors. Greater increases in CT1 cell proliferation were detected when the growth medium was supplemented with all three factors. Supplementing the culture medium with individual or multiple factors during bovine embryo culture resulted in several positive outcomes, including increased blastocyst development, expansion, and hatching to varying degrees depending on the particular factor or combination of factors. Supplementation of the culture medium with all three factors increased embryonic trophoblast cell numbers on Day 8, as well as hatching rates and blastocyst diameter on Day 12 after fertilisation. Western blot analyses and the use of pharmacological inhibitors suggest that EGF and IGF1 affect CT1 proliferation by activating mitogen-activated protein kinase 3/1, whereas FGF2 activates AKT. In conclusion, the findings of the present study indicate that there are cooperative interactions among EGF, FGF2 and IGF1 that enhance trophoblast cell development during early embryogenesis.

F164. Epidermal Growth Factor and Fibroblast Growth Factor-2 Circulating Levels in Elderly With Major Depressive Disorder

2018 ◽  
Vol 83 (9) ◽  
pp. S302
Author(s):  
Hanjing Emily Wu ◽  
Antonio Teixeira ◽  
Lucelia Barroso ◽  
Ana Paula Mendes Silva ◽  
Kelly Pereira Silva ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Depressive Disorder ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Major Depressive ◽  
Epidermal Growth ◽  
Circulating Levels
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