scholarly journals Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease

2009 ◽  
Vol 29 (6) ◽  
pp. 1860-1873 ◽  
Author(s):  
R. L. Buckner ◽  
J. Sepulcre ◽  
T. Talukdar ◽  
F. M. Krienen ◽  
H. Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Connectivity Mapping ◽  
Intrinsic Functional Connectivity

[IC-P-033]: LONGITUDINAL INTRINSIC FUNCTIONAL CONNECTIVITY CHANGES IN PRECLINICAL ALZHEIMER's DISEASE: A TWO-YEAR FOLLOW UP STUDY

2017 ◽  
Vol 13 (7S_Part_1) ◽  
pp. P30-P30
Author(s):  
Hyun Kook Lim ◽  
Chang Uk Lee ◽  
Dong Woo Kang ◽  
Yoo Hyun Um ◽  
Changtae Hahn ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Preclinical Alzheimer’S Disease ◽  
Follow Up Study ◽  
Intrinsic Functional Connectivity

Altered Functional Connectivity of the Marginal Division in Alzheimer’s Disease

2014 ◽  
Vol 11 (2) ◽  
pp. 145-155 ◽  
Author(s):  
Zengqiang Zhang ◽  
Yong Liu ◽  
Bo Zhou ◽  
Jinlong Zheng ◽  
Hongxiang Yao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Marginal Division

scholarly journals Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease

2021 ◽  
pp. 1-6
Author(s):  
Julia Schumacher ◽  
Alan J. Thomas ◽  
Luis R. Peraza ◽  
Michael Firbank ◽  
John T. O’Brien ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Lewy Body ◽  
Cholinergic System ◽  
Structural Changes ◽  
Lewy Body Dementia ◽  
Occipital Cortex ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert

ABSTRACT Cholinergic deficits are a hallmark of Alzheimer’s disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in neurodegenerative diseases. Forty-six LBD patients, 29 AD patients, and 31 healthy age-matched controls underwent resting-state functional magnetic resonance imaging (fMRI). A seed-based analysis was applied with seeds in the left and right NBM to assess functional connectivity between the NBM and the rest of the brain. We found a shift from anticorrelation in controls to positive correlations in LBD between the right/left NBM and clusters in right/left occipital cortex. Our results indicate that there is an imbalance in functional connectivity between the NBM and primary visual areas in LBD, which provides new insights into alterations within a part of the corticopetal cholinergic system that go beyond structural changes.

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