2012 ◽  
Vol 2 (2) ◽  
pp. 43-51
Author(s):  
J. Jacinth Salome

The DNA mciroarray gene data is in the expression levels of thousands of genes for a small amount of samples. From the microarray gene data, the process of extracting the required knowledge remains an open challenge. Acquiring knowledge is the intricacy in such types of gene data, though number of researches is arising in order to acquire information from these gene data. In order to retrieve the required information, gene classification is vital; however, the task is complex because of the data characteristics, high dimensionality and smaller sample size. Initially, the dimensionality diminution process is carried out in order to shrink the microarray data without losing information with the aid of LPP and PCA techniques and utilized for information retrieval. In this paper, we propose an effective gene retrieval technique based on LPP and PCA called LPCA. The technique like LPP and PCA is chosen for the dimensionality reduction for efficient retrieval of microarray gene data. An application of microarray gene data is included with classification by SVM. SVM is trained by the dimensionality reduced gene data for effective classification. A comparative study is made with these dimensionality reduction techniques.


2015 ◽  
Vol 294 ◽  
pp. 553-564 ◽  
Author(s):  
Manuel Domínguez ◽  
Serafín Alonso ◽  
Antonio Morán ◽  
Miguel A. Prada ◽  
Juan J. Fuertes

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Van Hoan Do ◽  
Stefan Canzar

AbstractEmerging single-cell technologies profile multiple types of molecules within individual cells. A fundamental step in the analysis of the produced high-dimensional data is their visualization using dimensionality reduction techniques such as t-SNE and UMAP. We introduce j-SNE and j-UMAP as their natural generalizations to the joint visualization of multimodal omics data. Our approach automatically learns the relative contribution of each modality to a concise representation of cellular identity that promotes discriminative features but suppresses noise. On eight datasets, j-SNE and j-UMAP produce unified embeddings that better agree with known cell types and that harmonize RNA and protein velocity landscapes.


2019 ◽  
Vol 165 ◽  
pp. 104-111 ◽  
Author(s):  
S. Velliangiri ◽  
S. Alagumuthukrishnan ◽  
S Iwin Thankumar joseph

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