Blue Eyes, Brown Eyes

2021 ◽  
Author(s):  
Stephen G. Bloom
Keyword(s):  
Blue Eyes

scholarly journals The Effect of Long-Term Low-Dose Atropine on Refractive Progression in Myopic Australian School Children

2021 ◽  
Vol 10 (7) ◽  
pp. 1444
Author(s):  
William Myles ◽  
Catherine Dunlop ◽  
Sally A. McFadden
Keyword(s):  
Low Dose ◽  
High Dose ◽  
Eye Drops ◽  
Myopia Progression ◽  
At Risk Children ◽  
Slow Group ◽  
Blue Eyes ◽  
Global Population ◽  
Axial Growth

Myopia will affect half the global population by 2050 and is a leading cause of vision impairment. High-dose atropine slows myopia progression but with undesirable side-effects. Low-dose atropine is an alternative. We report the effects of 0.01% or 0.005% atropine eye drops on myopia progression in 13 Australian children aged between 2 and 18 years and observed for 2 years without and up to 5 years (mean 2.8 years) with treatment. Prior to treatment, myopia progression was either ‘slow’ (more positive than −0.5D/year; mean −0.19D/year) or ‘fast’ (more negative than −0.5D/year; mean −1.01D/year). Atropine reduced myopic progression rates (slow: −0.07D/year, fast: −0.25D/year, combined: before: −0.74, during: −0.18D/year, p = 0.03). Rebound occurred in 3/4 eyes that ceased atropine. Atropine halved axial growth in the ‘Slow’ group relative to an age-matched model of untreated myopes (0.098 vs. 0.196mm/year, p < 0.001) but was double that in emmetropes (0.051mm/year, p < 0.01). Atropine did not slow axial growth in ‘fast’ progressors compared to the age-matched untreated myope model (0.265 vs. 0.245mm/year, p = 0.754, Power = 0.8). Adverse effects (69% of patients) included dilated pupils (6/13) more common in children with blue eyes (5/7, p = 0.04). Low-dose atropine could not remove initial myopia offsets suggesting treatment should commence in at-risk children as young as possible.

The Varied Causes of Color in Glass

1985 ◽  
Vol 61 ◽  
Author(s):  
K. Nassau
Keyword(s):  
Chalcogenide Glasses ◽  
Water Ligand ◽  
Ligand Field ◽  
Energy Bands ◽  
Metal Compounds ◽  
Chemical Mechanisms ◽  
Doped Glasses ◽  
Blue Eyes ◽  
Physical And Chemical ◽  
Ice Water

ABSTRACTAll but two of the fifteen physical and chemical mechanisms which are necessary to explain all the varied causes of color apply in one way or another to glass. These fifteen causes of color derive from a variety of physical and chemical mechanisms and are summarized in five groups with concentration on those mechanisms that apply to glass and the related glazes and enamels. Vibrations and simple excitations explain the colors of incandescence (e.g. flames, hot glass), gas excitations (neon tube, aurora), and vibrations and rotations (blue ice, water, glasses based on water). Ligand field effect colors are seen in transition metal compounds (turquoise, chrome oxide green, glasses based on copper sulfate) and impurities (ruby, emerald, many doped glasses). Molecular orbitals explain the colors of organic compounds (indigo, chlorophyll, organic glasses) and charge transfer compounds (blue sapphire, lapis lazuli, “beer-bottle” brown and chromate glasses). Energy bands are involved in the colors of metals and alloys (gold, brass, glassy metals), of semiconductors (cadmium yellow, vermillion, chalcogenide glasses), doped semiconductors (blue and yellow diamond), and color centers (amethyst, topaz, irradiated glass). Geometrical and physical optics are involved in the colors derived from dispersive refraction (rainbow, green flash, glass prism spectrum), scattering (blue sky, blue eyes, red sunset, ruby gold and opal glasses), interference (soap bubbles, iridescent beetles, cracks in glasses, interference filters), and diffraction (the corona aureole, diffraction grating spectrum).

INBORN ERROR OF HISTIDINE METABOLISM

PEDIATRICS ◽  
1962 ◽  
Vol 29 (5) ◽  
pp. 714-728
Author(s):  
H. Ghadimi ◽  
M. W. Partington ◽  
A. Hunter
Keyword(s):  
Ferric Chloride ◽  
Urocanic Acid ◽  
High Concentration ◽  
Normal Children ◽  
Total Lack ◽  
Normal Urine ◽  
One Year ◽  
The One ◽  
Blue Eyes ◽  
Derivatives Of

A 3-year-old girl with fair hair and blue eyes came under observation because of speech retardation. The patient was given a phenylalanine-free diet, since persistently positive urine tests with ferric chloride and reagent strips (Phenistix) were strongly suggestive of phenylketonuria. On further investigation she was found to be suffering from a totally different and not heretofore recognized condition, the salient features of which were an abnormally high concentration of histidine in the blood and an excessive output of histidine in the urine. The child's sister, one year older, presented the same metabolic anomaly. In each case both the concentration of histidine in plasma and the daily output were directly related to the amount of protein in the diet; but even at their lowest levels they greatly exceeded those of normal children of the same age. An oral load of histidine was followed by an increase of histidine in plasma much higher and more prolonged than that observed in controls, and by the excretion of a much larger fraction of the ingested dose. The urine of each sister contained not only excessive amounts of histidine but also notable quantities of imidazole-pyruvic, imidazole-acetic, and imidazole-lactic acid, histidine derivatives of which normal urine contains only traces. It is concluded that in the two sisters the normally predominant pathway of histidine catabolism, which leads through urocanic acid to glutamic acid, was partially or completely blocked. Since, even after histidine loading, the urines never contained detectable amounts of urocanic acid, the block must precede the formation of that substance. The condition presented is therefore due primarily to a deficiency or total lack of histidine-alpha-deaminase; the enzyme which converts histidine to urocanic acid. As a result of this defect histidine is forced to take the alternative but less efficient pathway which begins with its transamination to imidazole-pyruvic acid. This substance is the one responsible for positive reactions in the ferric chloride and Phenistix tests. All urine specimens examined, whether from the patient or from normal controls, contained considerable quantities of an unidentifiable imidazole compound ("X"), which does not appear to have been previously reported. The existence of this substance may call for some modification of current concepts of histidine metabolism in man.

Blue eyes as a risk factor for type 1 diabetes

2011 ◽  
Vol 27 (6) ◽  
pp. 609-613 ◽  
Author(s):  
Enrico Di Stasio ◽  
Daria Maggi ◽  
Enzo Berardesca ◽  
Georgiana Clare Marulli ◽  
Carla Bizzarri ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Risk Factor ◽  
Blue Eyes

Blue Eyes for Brown

Science ◽  
1933 ◽  
Vol 77 (1990) ◽  
pp. 191-192
Author(s):  
Vilhjalmur Stefansson
Keyword(s):  
Blue Eyes

THE VARIABILITY IN MANIFESTATIONS OF UNTREATED PATIENTS WITH PHENYLKETONURIA (PHENYLPYRUVIC ACIDURIA)

PEDIATRICS ◽  
1957 ◽  
Vol 20 (2) ◽  
pp. 290-302 ◽  
Author(s):  
Richmond S. Paine
Keyword(s):  
New England ◽  
Experimental Treatment ◽  
Hair Color ◽  
Eastern Canada ◽  
Number Of Patients ◽  
Objective Evidence ◽  
Comparable Control ◽  
Convulsive Seizures ◽  
Blue Eyes ◽  
Early Developmental

One hundred six cases of phenylketonuria have been surveyed in 11 institutions in New England and Eastern Canada. Data not previously available (and of some degree of uncertainty as to reliability) are presented as to the ages at which patients with phenylketonuria achieve the ability to sit unsupported, to walk independently, and to say recognizable words. A small number of patients achieve these steps at reasonably near the normal age and the degree of variability is such that early developmental timetables should not be overemphasized in interpreting possible effects of any treatment of the disease. Both eczema and seizures are proportionately more frequent in severely retarded patients with phenylketonuria than in those with lesser degrees of intellectual defect. If present at the time an experimental treatment is instituted, they would provide more objective evidence of possible benefit. Electroencephalograms were abnormal in 79% of patients for whom tracings were available and would provide one means of evaluating plans of treatment even in the absence of seizures. While the majority of these patients have blue eyes and blond hair, there is enough evidence to suggest a tendency to darkening of the hair with age that this also should be used with caution in evaluation of treatment. Frequencies of various neurologic manifestations are presented, including unusual hand posturing, tremor, hyperreflexia, clonus and spasticity. These are all variable enough that a reasonably positive diagnosis [See FIG. 2. in Source Pdf.] by physical examination is not possible, and further, they are not well adapted to evaluation of treatment. The distribution of intelligence quotients in patients with phenylketonuria appears to follow a continuous curve and to include a small number of persons with borderline normal or better intelligence. In assessing the effect of any treatment, it is unwarranted to ascribe to that treatment the attainment of borderline normal intellectual levels that may be reached by small numbers of patients, especially if originally tested in infancy or early childhood. The effect of any therapy can be adequately evaluated only by comparing changes in a number of treated patients with phenylketonuria, with changes in comparable control patients, selected on the basis of intelligence, age, physical accomplishments, and status with respect to hair color, eczema, convulsive seizures and electroencephalographic findings.

A LESSON ABOUT DRUNKARDS IN THE 1879 EDITION OF MCGUFFEY'S FIFTH ECLECTIC READER

PEDIATRICS ◽  
1978 ◽  
Vol 62 (1) ◽  
pp. 116-116
Author(s):  
T. E. C.
Keyword(s):  
Full Length ◽  
Young Reader ◽  
American Education ◽  
Human Being ◽  
Rocky Slope ◽  
Blue Eyes

Many have hailed the McGuffey Eclectic Readers as major influences not only in American education but in American morals and culture as well. It is estimated that 122,000,000 copies were sold between 1836 and 1920. A recurrent lesson in these Readers is the evils of drink. In the 1879 edition of the Fifth Reader, McGuffey chose this piece by John Greenleaf Whittier (1807-1892) to show the young reader the wretched effects of alcohol. . . . One fine morning, not long ago, I strolled down the Merrimac, on the Tewksbury shore. . . . The path winds, green and flower-skirted, among beeches and oaks, through whose boughs you catch glimpses of waters sparkling and dashing below. . . . Half fatigued with my walk, I threw myself down upon a rocky slope of the bank, where the panorama of earth, sky, and water lay clear and distinct about me. . . . Over all a warm but softened sunshine melted down from a slumberous autumnal sky. My revery was disagreeably broken. A low, grunting sound, half bestial, half human attracted my attention. I was not alone. Close beside me, half hidden by a tuft of bushes, lay a human being, stretched out at full length, with his face literally rooted into the gravel. A little boy, five or six years of age, clean and healthful, with his fair brown locks and blue eyes, stood on the bank above, gazing down upon him with an expression of childhood's simple and unaffected pity.

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