scholarly journals HUWE 1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

2016 ◽  
Vol 9 (2) ◽  
pp. 181-197 ◽  
Author(s):  
Kevin B Myant ◽  
Patrizia Cammareri ◽  
Michael C Hodder ◽  
Jimi Wills ◽  
Alex Von Kriegsheim ◽  
...  
Keyword(s):  
Dna Damage ◽  
Damage Accumulation ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Colonic Tumour ◽  
Tumour Initiation

DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter

2009 ◽  
Vol 422 (3) ◽  
pp. 543-551 ◽  
Author(s):  
Hanshao Liu ◽  
Hoi Chin Hew ◽  
Zheng-Guang Lu ◽  
Tomoko Yamaguchi ◽  
Yoshio Miki ◽  
...  
Keyword(s):  
Dna Damage ◽  
Target Genes ◽  
Core Promoter ◽  
Genotoxic Stress ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Dependent Manner ◽  
P53 Expression ◽  
Protein Levels

Transcriptional regulation of the p53 tumour suppressor gene plays an important role in the control of the expression of various target genes involved in the DNA damage response. However, the molecular basis of this regulation remains obscure. In the present study we demonstrate that RREB-1 (Ras-responsive-element-binding protein-1) efficiently binds to the p53 promoter via the p53 core promoter element and transactivates p53 expression. Silencing of RREB-1 significantly reduces p53 expression at both the mRNA and the protein levels. Notably, disruption of RREB-1-mediated p53 transcription suppresses the expression of the p53 target genes. We also show that, upon exposure to genotoxic stress, RREB-1 controls apoptosis in a p53-dependent manner. These findings provide evidence that RREB-1 participates in modulating p53 transcription in response to DNA damage.

tumour suppressor gene and the tobacco industry

The Lancet ◽  
2005 ◽  
Vol 365 (9464) ◽  
pp. 1026-1027
Author(s):  
A BITTON ◽  
M NEUMAN ◽  
J BARNOYA ◽  
S GLANTZ
Keyword(s):  
Tobacco Industry ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor

FOXL2 in adult‐type granulosa cell tumour of the ovary: oncogene or tumour suppressor gene?

2021 ◽  
Author(s):  
Jessica A. Pilsworth ◽  
Anne‐Laure Todeschini ◽  
Samantha J. Neilson ◽  
Dawn R. Cochrane ◽  
Daniel Lai ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Cell Tumour ◽  
Granulosa Cell Tumour ◽  
Adult Type
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